Analogue Drugs

Keywords Practical problems Generic drug Analogue drug Medication intake Food interactions... 

Grieg NH, Pei XH, Soncrant T, Ingram DK, Brossi A, Phenserine and ring C hetero-analogues, Drug candidates for treatment of Alzheimers disease, Med Res Reviews 15 3—31, 1995. 

The Controlled Substance Analogue Drug Bill. This is contained within Public Law 99-570,... 

The development of novel materials and the search for new bioactive compounds, such as natural products and analogues, drugs, diagnostics and agrochemicals, in academic and industrial chemistry is closely connected to the efficient preparation of such compounds. Thus, the view of synthesis has altered in recent years the development of new, highly selective methods will still be an important task, but the main focus of today s chemists is on efficiency [1], Multi-step syntheses with more than 20 steps have to be avoided since they are neither economically nor ecologically justifiable. Thus, modern syntheses must deal carefully with our resources and our time, must reduce the amount of waste formed, should use catalytic transformations and finally must avoid all toxic reagents and solvents. 

E. Functional Group Limitations with CaaX Analogue Drugs.289... 

The pioneer drug, captopril, had a relatively short duration of action. Nonetheless, with sublingual administration it is used to elicit beneficial hemodynamic and clinical effects in hypertensive crises, acute myocardial ischemia, and acute CHF. Several long-acting analogue drugs are used nowadays as a first-choice therapy in cardiovascular diseases, and their minor differences have been summarized in this chapter. 

The goal of the project is to study the role of analogue drugs for medicinal chemistry, and in this respect two interesting points have come to light ... 

Clearly, in order to have reached this level of importance, analogue drugs must... 

Today, it is not too difficult to identify analogues among the most frequently prescribed drugs, on the basis of their similarities in structure and biological properties. In the present book, analogue drugs have, for the first time, been collected systematically on the basis of two sources ... 

In this way, among the Top 500 most frequently used drugs, 67 analogue classes and 306 analogue drugs have been identified. 

The androgen testosterone is made in the testis and directs developmental maturation of male sex characteristics and normal function of male sex organs. Anabolic—androgenic steroid analogue drugs have been developed for increasing muscle mass. 

Woloschuk DM, Pruemer JM, Cluxton RJ Jr. Carboplatin a new cisplatin analogue. Drug Intell Clin Pharm 1988 22(ll) 843-9. 

Methadone maintenance involves replacing one opiate, say, heroin, with another, methadone. Another pharmacotherapy for heroin use involves blockade of opiate receptors by the use of naltrexone, w hich we discussed in the section on alcohol treatment. Naltrexone or its shorter-acting analogue drug, naloxone, is used most commonly with patients who have been maintained for long periods on methadone and then choose to become drug-free. The naltrexone may help these patients bridge... 

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