Monoamines, depletion

Kleven, M.S. Woolverton, W.L. and Seiden, L.S. Lack of long-term monoamine depletions following continuous or repeated exposure to cocaine. Brain Res Bull, in press. 

Eyerman, D.J., Yamamoto, B.K. Lobeline attenuates methamphetamine-induced changes in vesicular monoamine transporter 2 immunoreactivity and monoamine depletions in the striatum. J. Pharmacol. Exp. Ther. 312 160, 2005. 

Friedman, S.D., Castaneda, E., Hodge, G.K. Long-term monoamine depletion, differential recovery, and subtle behavioral impairment following methamphetamine-induced neurotoxicity. Pharmacol. Biochem. Behav. 61 35, 1998. 

Seiden, L.S., Woolverton, W.L., Lorens, S.A., Williams, J.E., Corwin, R.L., Hata, N., and Olimski, M., Behavioral consequences of partial monoamine depletion in the CNS after methamphetamine-like drugs the conflict between pharmacology and toxicology, NIDA Res. Monogr. 136, 34-46 discussion 46-52, 1993. 

Dopamine depleting agents. Reserpine, a natural alkaloid that blocks vesicular transport of monoamines, depletes stored monoamines, including DA. DA depletion is associated with the emergence of parkinsonism. This effect of reserpine was among the first clues that PD is the result of DA deficiency (see above). Generally, the parkinsonism resulting from reserpine is reversible. 

Suzuki T, Kisara K. 1985. Enhancement of phenol-induced tremor caused by central monoamine depletion. Pharmacol Biochem Behav 22 153-155. 

Rauwolfia Antipsychotic Reserpine Monoamine depletion via vesicular reuptake inhibition... 

Heninger GR, Delgado PL, Charney DS. (1996). The revised monoamine theory of depression a modulatory role for monoamines, based on new findings from monoamine depletion experiments in humans. Pharmacopsychiatry. 29(1) 2-11. 

Wachtel, H. and Schneider, H.H. (1986) Rolipram, a novel antidepressant drug, reverses the hypothermia and hypokinesia of monoamine-depleted mice by an action beyond postsynaptic monoamine receptors. Neuropharmacology 25(10) 1119-1169. 

Ruh6 HG, Mason NS, Schene AH (2007) Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans a meta-analysis of monoamine depletion studies. Mol Psychiatry 12 331-59... 

Swanson CJ, Schoepp DD. 2002. The group II metabotropic glutamate receptor agonist (-)-2-oxa-4-aminobicyclo [3.1.0.]hexane-4,6-dicarboxylate (LY379268) and clozapine reverse phencyclidine-induced behaviors in monoamine-depleted rats. J Pharmacol Exp Ther 303 919-927. 

Annett LE, Rogers DC, Hernandez TD, Dunnett SB (1992) Behavioural analysis of unilateral monoamine depletion in the marmoset. Brain 775 825-856. 

Brodkin J, Malyala A,Nash JF (1993) Effect of acute monoamine depletion on 3,4-methylenedioxymethamphetamine-induced neurotoxicity. Pharmacol Biochem Be-hav 45 647-653. 

Booij L, Van der Does AJW, Riedel WJ. Monoamine depletion in psychiatric and healthy populations review. Mol. Psychiatry 2003 8 951-973. 

Category Central Monoamine-Depleting Agent Half-life N/A... 

Marek, G.J. Vosmer, G. and Seiden, L.S. The effects of monoamine uptake inhibitors and methamphetamine on neostriatal 6-hydroxy-dopamine (6-OHDA) formation, short-term monoamine depletions and locomotor activity in the rat. Brain Res 516 1-7, 19906. 

Stauch Slusher B, Rissolo KC, Jackson PF et al (1994) Centrally-administered glycine antagonists increase locomotion in monoamine-depleted mice. J Neural Transm Gen Sect 97 175-185... 

Reserpine has a number of biochemical actions. It potentiates and prolongs the elevation of liver diphosphopyridine nucleotides brought about by nicotinamide. This action is shared by reserpine derivatives which have tranquillizing properties but not by those without tranquillizing activity . This effect is thus as characteristic as is monoamine depletion. 

Klockgether, T., Turski, L., Honor6, T., Zhang, Z., Gash, D.M., Kurlan, R. and Greenamyre, J.T. (1991) The AMPA receptor antagonist NBQX has antiparkinsonian effect in monoamine-depleted rats and MPTP monkeys. Ann. Neurol. 30 717-723. 

A better resemblance to the human depressive state in comparison with monoamine-depleted animals is claimed for animal separation models. Dog puppies separated from their mother display behavioural syndromes similar to human depression in which vocalization is most pronounced. Among a large number of drugs, imipramine was found most effective in reducing vocalization, without causing sedation [28]. 

PSEUDOPREGNANCY AFTER MONOAMINE DEPLETION IN THE MEDIAN EMINENCE OF THE RAT... 

The present study was undertaken in order to obtain more direct information on the role of hypothalamic monoamines in the control of prolactin secretion. In case of systemic administration of drugs like reserpine the locus of action would remain unknown, and, moreover, effects other than on monoamine depletion would not be excluded. Therefore, an amount of approximately 2 jig reserpine was implanted into the hypothalamus of female rats, and the distribution of fluorescent material, indicating the presence of monoamines, was studied in the median eminence. It appeared that such implantations could cause a complete disappearance of the fluorescence in this area. The animals were otherwise completely normal, indicating that the implanted reserpine had no systemic effects. 

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