Delivery system /vehicle

Uses Soivent for pharmaceuticals, cosmetics, water-based inks slowly evaporating solvent in insecticide delivery systems vehicle for veterinary injectables (sulphadiazine, trimethoprin, antiparasite, intramuscular injections)... 

In this work we will focus on the use of the cubic phase as a delivery system for oligopeptides - Desmopressin, Lysine Vasopressin, Somatostatin and the Renin inhibitor H214/03. The amino acid sequences of these peptides are given in Table I. The work focuses on the cubic phase as a subcutaneous or intramuscular depot for extended release of peptide drugs, and as a vehicle for peptide uptake in the Gl-tract. Several examples of how the peptide drugs interact with this lipid-water system will be given in terms of phase behaviour, peptide self-diffusion, in vitro and in vivo release kinetics, and the ability of the cubic phase to protect peptides from enzymatic degradation in vitro. Part of this work has been described elsewhere (4-6). 

Defining hydrogen fuel quality specifications is a high priority for the Roadmap. Such specifications must be quantified at the vehicle-station interface and must consider how the presence of small amounts of contaminants affects the performance and durability of fuel cell and balance of plant material compatibility of onboard and stationary hydrogen storage systems and the operation and maintenance of hydrogen production, purification, and delivery systems. Most importantly, fuel quality specification must consider... 

The copolymer-based systems possessing the core-shell structure in solutions are known and studied rather well (see, e.g., [14-16]). These copolymers in aqueous media tend to form polymeric micelles, which are often considered as promising drug delivery nano-vehicles [ 17,18], i.e., these macromolecular systems are not only of scientific, but also of considerable applied significance. Among such systems there are interesting examples, whose properties are very similar to the properties that should be inherent in the protein-like copolymers. All of these macromolecules possess the primary structure of... 

Some drug delivery systems contain nutrients. For example, the vehicle for propofol is 10% lipid emulsion and most IV therapies include dextrose or sodium. 

The road to hydrogen vehicles and a hydrogen fueling delivery system may take many paths. Today, it may seem unlikely that market forces alone will result in the installation of thousands of hydrogen fueling stations across the country. But, this is exactly what happened with our pres-... 

An interesting feature of current commercial products is that the polymer vehicles available for formulation have been limited to nonionic and anionic materials. The delivery vehicles available included off-the-shelf polymers such as carboxymethylcellulose, soluble starch, hydroxyethyl-cellulose, polyvinyl alcohol, poly(acrylic acid), and polyvinylpyrrolidone, or mixtures thereof. The choice of available polymeric delivery system primarily depends on component compatibility, aesthetics, and efficacy. However, by reliance upon available (off-the-shelf) systems, limitations on bioadhesion, drug bioavailability, contraceptive efficacy, and end-use characteristics has been limited. 

Conventional vaginal delivery systems include tablets, foams gels, suspensions, and pessaries. Mucoadhesive gel formulations based on polycarbophil have been reported to remain 3 to 4 days at the vaginal tissue, providing an excellent vehicle for the delivery of progesterone and nonoxynol-9 [66]. 

Dehvering pharmaceutical agents to specific cells in the body is a difficult task involving complex interactions between many elements. Delivery systems have several fundamental requirements to achieve this task. The delivery vehicle must be ingesti-ble, implantable, or injectable to introduce the dmg into the body. The system must then protect the drug from the body s defense mechanisms in order to accumulate in selected cells. Once at the target, the delivery system should release the enclosed pharmaceutical agent with a controllable and predictable profile. Finally, the delivery vehicle should be biocompatible, nontoxic, and easily eliminated from the body. 

The inert matrix formulation provided by ethylcellulose and Pevikon (polyvinyl chloride) was an effective vehicle for controlled release drug delivery systems. 

Self-assembly of polymers in the bulk Polymer micelles, polymero-somes, gelled macromole-cules, nano-tubes, protein fibres/tapes produced by aggregation at low pH, controlled release vehicles, smart delivery systems 50-500 nm Forster and Konrad, 2003 Sanguansri and Augustin, 2006 Dickinson 2006a Graveland-Bikker and de Kruif, 2006 van der Linden, 2006... 

Electrostatic self-assembly of polymers in the bulk Polyelectrolyte capsules controlled release vehicles, smart delivery systems 50-500 nm Anal et al., 2008... 

Wu, S. H., 1998. Vitamin E TPGS as a vehicle for drug delivery system. Paper presented at AAPS short cours ormulation with Lipids, Parsippany, NJ, June 3, 1998. 

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