Controlled release capsules

Procardia XL. Procardia XL extended-release capsules, marketed by Pfizer Labs Division of Pfizer, Inc., contain nifedipine [21829-25-4] a calcium channel blocker of mol wt 346.3. The extended release tablet is formulated as a once-a-day controlled release capsule for oral adrninistration dehvering either 30, 60, or 90 mg nifedipine. Procardia XL is indicated for use in the management of vasospastic angina, chronic stable angina, and hypertension (see Cardiovascularagents). 

Pentasa Microgranule controlled-release capsule 250 mg 500 mg 2-4 g 2-4 g Small bowel Colon... 

Oral Asacol 400 mg delayed-release tablets Pentasa 250 mg controlled-release capsules Rectal Rowasa 4 g/60 mL suspension Canasa 500, 1000 mg suppositories Methylprednisolone (Medrol Enpack)... 

Soft gelatin-based controlled-release capsules... 

Dong, L.C., etal., Controlled release capsule for delivery of liquid formulation, US patent application 20040058000, published in 2004. 

Niwa, K., Takaya, T., Morimoto, T., and Takada, K. (1995), Preparation and evaluation of a time-controlled release capsule made of ethylcellulose for colon delivery of drugs, J. Drug Target., 3, 83-89. 

Wilding, I. Prior, D.V. Remote controlled release capsules in human drug absorption (HDA) studies. Crit. Rev. Ther. Drug Carrier Syst. 2003, 20, 405-431. 

Tu J, Wang L, Yang J, et al. Formulation and pharmacokinetics studies of acyclovir controlled-release capsules. Drug Dev Ind Pharm 2001 27(7) 687-692. 

Mesalamine (5-aminosalicylic acid asacol, others) is a salicylate that is used for its local effects in the treatment of inflammatory bowel disease (see Chapter 38). It currently is available as a suppository and rectal suspension enema (rowasa) for treatment of mild-to-moderate proctosigmoiditis Cl rectal suppository (canasa, others) for the treatment of distal ulcerative colitis, proctosigmoiditis, or proctitis. Oral formulations and controlled-release capsule that deliver drug to the lower intestine are efficacious in treatment of inflammatory bowel disease, in particular ulcerative colitis. Sulfasalazine (salicylazosulfapyridine azulfidine) contains mesalamine linked covalently to sulfapyridine (see Chapter 38) it is absorbed poorly after oral administration, but it is cleaved to its active components by bacteria in the colon. The drug is of benefit in the treatment of inflammatory bowel disease, principally because of the local actions of mesalamine. 

Edsb ker S, Larsson P, Bergstrand M. Pharmacokinetics of budesonide controlled-release capsules when taken witii omeprazole.zf/imewfP/ianwaco/ 772er(2003) 17,403-8. 

Tablet formulation of a high solubility drug Tablet formulation of a low solubility drug Controlled release capsule formulation...

Fig. 4.21. Partial GC chromatograms (18 0-18 2n-6) of total milk fat FAME from a cow fed a control diet that showed a high content of 10f-18 1.The lower GC graph shows the separation of the trans- 8 isomers by GC at 120°C after prior isolation of the trans fraction by Ag+-TLC. The insert shows the CLA regions of the same milk fat. The cow had been administered monenesin-control release capsules and fed a total mixed ration high in corn ingredients.

Melendez, R, J.R Goff, C.A. Risco, L.R Archhald, R. Littell, and G.A. Donovan. Effect of Monensin Controlled-Release Capsule on Rumen and Blood Metabolites in Florida Holstein Transition Cows, jjx 2- 7 - 4182—4189 (2004). 

Finally, it must be borne in mind that in the case of controlled release capsules the effect is still hmited - when all the capsules are empty they cannot be refilled. 

The increasing use of robotic platforms for sample preparation is reflected by the large number of articles that continue to be reported in the literature. In a recent literature publication, an automated Zymate TPWII sample preparation method was developed for the analysis of drugs in plasma in which theophylline was used as a probe drug. This method yielded better results than the conventional manual sample preparation method. " In another literature publication, a manual sample preparation for a controlled release capsule formulation was converted to an automated Zymate TPWII sample preparation method. This conversion achieved comparable results to the manual method in terms of recovery, precision, carryover, and filter selection. ... 

Uses Emulsifier, thickener, opacifier, suspending agent for cosmetics, pharmaceuticals, hair straighteners, moisturizers, nail preps., sunscreens, antibiotic creams and lotions, acne preps., analgesic rubs stabilizer for o/w emulsions emulsifier for pharmaceutical orals, creams, and lotions controlled release capsule fill and wax matrix applies. 

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