Self peptides

T cells induced by an agonist self peptide. Nat Immunol 2001 2 301-306. 

Jordan MS, Boesteanu A, Reed AJ, Petrone AL, Holenbeck AE, Lerman MA, Naji A, Caton AJ Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol 2001 2 301-306. 

Jordan MS, Riley MR von Boehmer H, Caton AJ Anergy and suppression regulate CD4 4- T cell responses to a self peptide. Eur J Immunol 2000 30 136-144. 

Inappropriate expression of class II MHC molecules on the membranes of cells that normally do not express class II MHC (eg, islet beta cells). Increased expression of MHC II may increase presentation of self peptides to T helper cells, which in turn induce CTL, TDTH, and B-lymphocyte cells that react against self antigens. 

Shih, F.F., Cerasoli, D.M., and Caton, A.J. (1997) A major T cell determinant from the influenza virus hemagglutinin (HA) can be a cryptic self peptide in HA transgenic mice. Int. Immunol. 9,249-261. 

Garcia, K. C., Degano, M., Pease, L. R., Huang, M., Peterson, P. A. et al. (1998). Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. 

Cells constantly process endogenous proteins and present self-peptide fragments, within the context of MHC class I, on their surfaces. Immune effector cells do not react to self-peptides within MHC class I, but as such are able to recognise when foreign peptides are instead presented, for example during an infection or cancer. 

Phagocytic cells, such as macrophages, neutrophils and monocytes, may engulf foreign particles and present non-self-peptides on MHC class II molecules. 

Mitchell, D. )., Fathman, C. G., Steinman, L. (1999). Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease modulation of T cell costimulation./. Immunol. 162, 3336-3341. 

Figure 33.40. T-Cell Selection. A population of thymocytes is subjected first to positive selection to remove cells that express T-cell receptors that will not bind to MHC proteins expressed by the individual organism. The surviving cells are then subjected to negative selection to remove cells that bind strongly to MHC complexes bound to self-peptides.

Figure 7-1 Activation of T cells by metal ions. Nickel and other metal ions appear to activate specific T cells by several different molecular mechanisms. (1) T cells with their T cell receptor respond to complexes of nickel with MHC-peptide similar to other hapten-peptide complexes. (2) Nickel forms a direct linker between MHC and the T cell receptor independent of the peptide with some similarities to superantigen-mediated T cell stimulation. (3) The processing of self peptides is disturbed by nickel resulting in cryptic self peptides presented to a T cell receptor.

Cells that bind strongly to MHC or MHC-self-peptide complexes are eliminalud... 

Vladden, L). R., Gorga, J. C., Strominger, J. L.. and Wiley, D. C. 1991. The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation. ANature 353 321-325. 

Falk K, Rotzschke O, Stevanovic S, Jung G, Rammensee HG Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 1991 351 290-296. 

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