Delivery system photodynamic therapy

Hasan, T. (1992) Photosensitizer delivery mediated by macromolecular carrier systems, in Henderson, B.W. and Dougherty, T.J. (Eds.) Photodynamic Therapy. Basic Principles and Clinical Applications, New York Marcel Dekker... 

H.E. de Vries, A.C. Moor, T.M. Dubbelman, T.J. van Berkel, J. Kuiper (1999). Oxidized low-density lipoprotein as a delivery system for photosensitizers implications for photodynamic therapy of atherosclerosis. J. Pharmacol. Exp. Then, 289, 528-534. 

G. Kostenich, A. Orenstein, L. Roitman, Z. Malik, B. Ehrenberg (1997). In vivo photodynamic therapy with the new near-IR absorbing water soluble photosensitizer lutetium texaphyrin and a high intensity pulsed light delivery system. J. Photochem. PhotobioL B, 39, 36-42. 

Figure 8.6 Schematic diagram of the light delivery system for irradiation measurements. Seim et al, 2007. Novel flexible light diffuser and irradiation properties for photodynamic therapy. Journal of Biomedical Optics 12(3), p. 034024. Available at http //www.ncbi.nlm.nih. gov/pubmed/17614732 (accessed 30.09.14.).

In another application, the delivery of therapeutic molecules to treat inflammatory disorders such as rheumatoid arthritis was investigated. Macrophage cells, of the immune system, are targeted for photodynamic therapy as a treatment for this disorder. Schmitt et al. developed chitosan-based... 

Hasan, T. Photosensitizer delivery mediated by mactomolecular 164. carrier systems. In Photodynamic Therapy Basic Principles and Clinical Applications-, Henderson, B. W. Dougherty, T. J., Eds. 165. Marcel Dekken New York, 1992, pp. 187-200. 

While most nanocapsule (NC) shells used in drug delivery systems are prepared from linear polyelectrolytes that lack any function other than that of drug container, this system employs DP not only as a polyelectrol)rte for the formation of NC shells but also as photosensitizing units for photodynamic therapy. Cell viability studies showed that combined treatment resulted in higher toxicity than either chemotherapy or PDT alone. 

Sharmon WM, van Lier JE, Allen CM (2004) Targeted photodynamic therapy via receptor mediated delivery systems. Adv Drug Deliv Rev 56 53-76... 

S.F. Purkiss, R. Dean, J.T. Allardice, M. Grahn, N.S. Williams An interstitial light delivery system for photodynamic therapy within the liver. Lasers Med. Sci. 8, 253 (1993)... 

Abstract. This chapter presents the basic sciences involved in photodynamic therapy, in terms of the photophysical, photochemical and photobiological principles the technologies of PDT light sources, delivery systems and dosimetry devices and optical methods that are under development for monitoring the response of tissue to PDT. The current and potential medical applications are also indicated. The discussion includes both aspects of PDT that are well-established and new concepts in the science, technology or clinical applications, including work from the author s laboratory. 

Recent years have witnessed the development of new nanoscale drug carriers such as CNPs that can be used for photodynamic therapy [60]. In the context of nanomedicine-based therapeutics, effective cancer therapy requires drug delivery to cancer tissues, meaning that a drug delivery system should hold the anticancer drug in the blood and then allow a burst or continuous drug release at the cancer site. 

These PpIX-loaded chitosan-based nanoparticles (PpIX-CNPs) showed a sustained release profile of PpIX and were biocompatible to tumor cells without irradiation. With SCC7 murine cell carcinoma cells, we observed fast cellular uptake of the PpIX-CNPs and the released PpIX exhibited high phototoxicity after laser irradiation. In vivo imaging and therapy with SCC7 tumor-bearing mice showed enhanced tumor specificity and increased therapeutic efficacy of PpIX-CNPs compared to free PpDC. These results indicated that these chitosan-based nanoparticle systems have great potential as fine delivery system for photodynamic therapy. 

In this chapter, we will focus on the self-organization of amphiphilic CD which form self-assembled colloidal systems with specific functionalities. In particular, the potential application of CD nanoaggregates and their nano-structured complexes with different guests in drug delivery will be mentioned. Light scattering and fluorescence techniques will be presented in order to characterize in detail their structure in aqueous solution. In this respect heterotopic colloids of amphiphilic cyclodextrins and photosensitizers will be shown as potential novel systems for targeted photodynamic therapy of tumours (PDT). 

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