Gene delivery vectors

Kost, T. A., and Condreay, J. P. (2002). Recombinant baculovirases as mammalian cell gene-delivery vectors. Trends Biotechnol. 20 173—180. [Pg.197]

Singh R, Pantarotto D, McCarthy D, Chaloin O, Hoebeke J, Partidos CD, Briand JP, Prato M, Bianco A, Kostarelos K (2005) Binding and condensation of plasmid DNA onto functionalized carbon nanotubes Toward the construction of nanotube-based gene delivery vectors. J. Am. Chem. Soc. 127 4388 4396. [Pg.49]

Li S, Huang L. Functional polymorphism of liposomal gene delivery vectors lipoplex and lipopolyplex. In Janoff AS, ed. Liposomes Rational Design. New York Marcel Dekker, Inc., 1999 89. [Pg.251]

Keller M, Harbottle RP, Perouzel E, et al. Nuclear localisation sequence tern-plated nonviral gene delivery vectors investigation of intracellular trafficking events of LMD and LD vector systems. Chembiochem 2003 4(4) 286-298. [Pg.316]

Langer and coworkers synthesized a series of copolymers containing various amounts of diacrylate and amine monomers, investigating copolymer composition with the ability to act as transport DNA into cells. They screened 140 copolymers as synthetic gene-delivery vectors. Of these, 56 were able to bind DNA. These polymers were then screened for their ability to facilitate the transfer of plasmid DNA into a common monkey cancer cell line. Two of the copolymers with quite varied compositions showed good activity—one expected and the other unexpected. The expected copolymer composition would have been a selected composition in a typical search and the other would have been omitted. Thus, combinatorial-like approaches can offer unexpected results to problems. [Pg.715]

The library was screened for DNA-complexing materials as well as gene delivery vectors, revealing several new materials that were able to condense DNA... [Pg.9]

Kang HC, Lee M, Bae YH (2007) Polymeric gene delivery vectors. In Peppas NA, Hilt JZ, Thomas JB (ed) Nanotechnology in therapeutics Taylor and Francis, New York... [Pg.143]

Read, M.L., Etrych, T., Ulbrich, K., Seymour, L.W. (1999). Characterisation of the binding interaction between poly(L-lysine) and DNA using the fluorescamine assay in the preparation of non-viral gene delivery vectors. FEBS Lett., 461(1-2), 96-100. [Pg.373]

Dash, P.R., Read, M.L., Fisher, K.D., et al. (2000). Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin. J. Biol. Chem., 275, 3793-3802. [Pg.375]

Ogris M, Carlisle RC, et al. Melittin enables efficient vesicular escape and enhanced nuclear access of nonviral gene delivery vectors. J Biol Chem 2001 276(50) 47550-47555. [Pg.369]

Fominaya, J., Gasset, M., Garcia, R., Roncal, F., Albar, J.P. and Bemad, A. (2000) An optimized amphiphilic cationic peptides as an efficient non-viral gene delivery vector. J. Gene Med., 2, 455 164. [Pg.331]

Figure 17.1 Chemical structures of poly cationic polymers used as gene delivery vectors.

Lotze MT, Kost TA (2002) Viruses as gene delivery vectors application to gene function, target validation, and assay development. Cancer Gene Ther 9(8) 692-699... [Pg.12]

Onishi Y, Eshita Y, Murashita A et al (2005) Synthesis and characterization of 2-diethyl-aminoethyl-dextran-methyl methacrylate graft copolymer for nonviral gene delivery vector. J Appl Polym Sci 98 9-14... [Pg.183]

Saraf A, Hacker MC, Sitharaman B et al (2008) Synthesis and conformational evaluation of a novel gene delivery vector for human mesenchymal stem cells. Biomacromolecules 9 (3) 818-827... [Pg.185]

Thanou M, Florea BI, Geldof M et al (2002) Quatemized chitosan oligomers as novel gene delivery vectors in epithelial cell lines. Biomaterials 23 153-159... [Pg.186]

Kean T, Roth S, Thanou M (2005) Trimethylated chitosans as non-viral gene delivery vectors cytotoxicity and transfection efficiency. J Control Release 103 643-653... [Pg.186]

Lou Y-L, Peng Y-S, Chen B-H et al (2009) Poly(ethylene imine)-g-chitosan using EX-810 as a spacer for nonviral gene delivery vectors. J Biomed Mater Res A 88A(4) 1058-1068... [Pg.187]

Yang C, Li H, Goh SH et al (2007) Cationic star polymers consisting of [alpha]-cyclodextrin core and oligoethylenimine arms as nonviral gene delivery vectors. Biomaterials 28... [Pg.189]

Schaffer DV, Lauffenburger DA (2000) Targeted synthetic gene delivery vectors. Curr Opin Mol Ther 2 155-161... [Pg.243]

Oupicky D, Ogris M, Howard KA et al (2002) Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation. Mol Ther 5 463 172... [Pg.244]

Shuai X, Merdan T, Unger F et al (2003) Novel biodegradable ternary copolymers hy-PEI-g-PCL-b-PEG synthesis, characterization, and potential as efficient nonviral gene delivery vectors. Macromolecules 36 5751-5759... [Pg.246]

Kim HJ, Kwon MS, Choi JS et al (2007) Synthesis and characterization of poly (amino ester) for slow biodegradable gene delivery vector. Bioorg Med Chem 15 1708-1715... [Pg.247]

Twaites BR, CdlH A, Cunliffe D et al (2004) Thermo and pH responsive polymers as gene delivery vectors effect of polymer architecture on DNA complexation in vitro. J Control Release 97 551-566... [Pg.250]

Twaites BR, CdLH A, Lavigne M et al (2005) Thermoresponsive polymers as gene delivery vectors cell viability, DNA transport and transfection studies. J Control Release 108 472-483... [Pg.250]

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