Unmet clinical needs

Cough is currently a huge unmet clinical need, as none of the currently available treatments are reliably effective [2]. However, there are many treatments which are currently used, with variable levels of success. In addition, if it is caused by another condition, such as gastro-oesophageal reflux disease, then treatment of that may reduce cough. 

Sachs GS. Unmet clinical needs in bipolar disorder. 

To assess the efficacy, safety and quality of new drugs to meet unmet clinical needs. 

A pharmaceutical organization has to determine which medical area has an unmet clinical need for an effective prophylactic or therapeutic intervention. 

Hirsh J. Current anticoagulant therapy—unmet clinical needs. Thromb Res 2003 109 S1-S8. 

Usually, scientists are directed to research new targets in specific therapeutic areas based on unmet clinical needs. Once a need is identified and a particular therapeutic area chosen, the biological research begins. It is during this first stage of drug discovery that anecdotal clinical observations, empirical outcomes, and data collected from folk medicine are often employed—if only as direction-finding tools. 

AM is innovative in that it fulfills an unmet clinical need with a human tissue-derived solution that does not introduce new materials into the human body. AM addresses a global health issue with an available source of human biomaterial. The product may provide an innovative source of human mesenchymal stem cells and their delivery for tissue regeneration. 

The Unmet Clinical Need Advantages of Tissue-Engineered... 

Hemodialysis continues to be the largest volume market for polymer membranes. While this is a very mature commodity market, unmet clinical needs continue to drive research along a number of fronts. 

One of the unmet clinical needs of orthopedic trauma surgeons is a bone glue or an adhesive to fix a broken bone instead of the conventional metal plates, nails, pins, and screws. Simplicity, quickness, and preservation of joint function, especially when fixing fractures with many small fragments, are the main benefits of a bone adhesive. An additional benefit is elimination of metal removal from fractures fixed solely with a biodegradable adhesive. 

---