Activating fragments

Morishita, H., et al. (2002). Cloning and characterization of an active fragment of luciferase from a luminescent marine alga, Pyrocystis lunula. Photochem. Photobiol. 75 311-315. 

NPY is primarily (but not exclusively) synthesised and released by neurons, which in the peripheral nervous system are predominantly sympathetic neurons [1]. In most cases, NPY acts as a co-transmitter that is preferentially released upon high frequency nerve stimulation. NPY can be metabolised by the enzyme dipeptidylpeptidase IV (also known as CD26) to generate the biologically active fragment NPY3 36. 

A purified protein having the amino acid sequence for ORF-1 (SEQ ID No 2) or an enzymatically active fragment thereof. 

US6133016 [64] biodesulfurization catalyst. enzyme having an amino acid sequence3 set forth in SEQ ID No. 2 or an enzymatically active fragment thereof. 

The specifically labeled proteins are isolated and subjected to limited proteolytic digestion or chemical fragmentation. The highest (radio)activity fragments... 

Over the last three years there have been a significant number of reports in which weakly active fragment hits have been identified and progressed into potent lead compounds (potency < 1 pM) and Table 1 summarises these reports. The table is ordered with the most challenging targets first. 

Although many of the investigations aimed at identifying host defense peptide receptors have focused on those localized to the cell surface, it has also been demonstrated that these peptides may utilize intracellular receptors. For example, a 15-residue active fragment of porcine peptide PR-39 has been demonstrated to bind cytosolic adaptor protein pi 30 " resulting in its association with the cytoskeleton and activation of downstream signaling pathways, including Bao et d have also demonstrated that the PR-39 peptide... 

Although more limited, sufficient spectroscopic data is available on the HO-2 isoform to confirm that the proximal ligand is also an imidazole. A 28-kDa catalytically active fragment of human HO-2 obtained by tryptic digestion of the enz5mie expressed in E. coli was shown by optical, resonance Raman, and EPR studies to have a neutral (imionized)... 

Lin, M., Rose-John, S., Gotzinger, J., Conrad, U., and Scheller, J. (2006). Functional expression of a biologically active fragment of soluble gpl30 as an ELP-fusion protein in transgenic plants pnrification via inverse transition cycling. Biochem. J. 398 577-583. 

A. General description Denileukin dif-titox is a recombinant, DNA-derived, interleukin-2 receptor specific ligand, cytotoxic fusion protein consisting of diphtheria toxin fragments A and B fused to interleukin-2. It is produced by expression of a recombinant fusion protein in Escherichia coli that contains nucleotide sequences for human interleukin-2, and sequences for the enzymatically active fragment A of diphtheria toxin and the membrane-translocating portion of diph-... 

ID-myo-inositol 1,3,4,5-tetrakisphosphate <1> (<1> recombinant, catalytically active fragment of isoform C, allosteric product activation in the absence of Ca /calmodulin, which per se activates enzyme and abolishes the allosteric effect [31]) [31]... 

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