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Cycloalkylations

When fhe ring confams fewer carbon afoms fhan an alkyl group affached to if fhe com pound IS named as an alkane and fhe ring is freafed as a cycloalkyl subsfiluenf... [Pg.77]

Name the compound as a cycloalkyl substituted alkane if the substituent has more carbons than the ring... [Pg.97]

Dehydrohalogenation of cycloalkyl halides lead exclusively to cis cycloaUcenes when the ring has fewer than ten carbons As the ring becomes larger it can accommo date either a cis or a trans double bond and large nng cycloalkyl halides give mixtures of CIS and trans cycloalkenes... [Pg.213]

R may be methyl or primary secondary or tertiary alkyl it may also be a cycloalkyl alkenyl or aryl group)... [Pg.591]

Cycloalkylation of aromatic compounds with 1,4- or 1,3-glycols ia the presence of aluminum chloride leads to the formation of derivatives of tetrahydronaphthalene oriadane, respectively (55). [Pg.555]

Double Fiiedel-Ciafts alkylation of configuiationally pure pyiocene (a substituted lactone) with aiomatics results in the formation of cycloalkylation product with retention of configuration at the chiral center (63). [Pg.556]

Table 7 shows that the nature of the alkyl group, whether primary alkyl, secondary alkyl, or cycloalkyl, does not affect the 10-h half-life temperatures of diaLkyl peroxydicarbonates in trichloroethylene (TCE). AH peroxydicarbonates have about the same 10-h half-life temperature in TCE (49—50°C). [Pg.226]

The (A/-alkylated) lactam of 8-aminonaphthalenecarboxylic acid (47) also is a valuable dye iatemiediate, eg, for cyclometbine-type dyes used for dyeiag polyacrylonitrile fibers and other synthetics. 1,8-Naphtholactams are prepared in high yield and purity by the reaction of naphtholactones with RNH2 (R = H, Cl—4 alkyl, cycloalkyl, or optionally substituted aryl) in aqueous medium, usually in the presence of bisulfite at 150°C over a period of 15 h (143). [Pg.506]

Dialkyl peroxides have the stmctural formula R—OO—R/ where R and R are the same or different primary, secondary, or tertiary alkyl, cycloalkyl, and aralkyl hydrocarbon or hetero-substituted hydrocarbon radicals. Organomineral peroxides have the formulas R Q(OOR) and R QOOQR, where at least one of the peroxygens is bonded directly to the organo-substituted metal or metalloid, Q. Dialkyl peroxides include cyclic and bicycflc peroxides where the R and R groups are linked, eg, endoperoxides and derivatives of 1,2-dioxane. Also included are polymeric peroxides, which usually are called poly(alkylene peroxides) or alkylene—oxygen copolymers, and poly(organomineral peroxides) (44), where Q = As or Sb. [Pg.105]

Thermal decompositions of di-Z fZ-cycloalkyl peroxides produce Z fZ-cycloalkoxy radicals which undergo ring -scission to give acycHc ketones,diketones, and other products (44) ... [Pg.107]

There are two broad classes of organic peroxyacids peroxycarboxyUc acids, R[C(0)00H], where R is an alkyl, aralkyl, cycloalkyl, aryl, or heterocycHc group and n = 1 or 2, and organoperoxysulfonic acids, RSO2—OOH. PeroxycarboxyUc acids are commonly named by adding the prefix peroxy to the parent acid as in peroxypropionic acid. The prefix per- is accepted only for the weU-estabHshed products, ie, performic, peracetic, and perbenzoic acids. [Pg.118]

Amines are derivatives of ammonia in which one or more of the hydrogens is replaced with an alkyl, aryl, cycloalkyl, or heterocycHc group. When more than one hydrogen has been replaced, the substituents can either be the same or different. Amines are classified as primary, secondary, or tertiary depending on the number of hydrogens which have been replaced. It is important to note that the designations primary, secondary, and tertiary refer only to the number of substituents and not to the nature of the substituents as in some classes of compounds. [Pg.257]

Appllca.tlons. MCA is used for the resolution of many classes of chiral dmgs. Polar compounds such as amines, amides, imides, esters, and ketones can be resolved (34). A phenyl or a cycloalkyl group near the chiral center seems to improve chiral selectivity. Nonpolar racemates have also been resolved, but charged or dissociating compounds are not retained on MCA. Mobile phases used with MCA columns include ethanol and methanol. [Pg.100]

Transesterification has become a convenient method for synthesi2ing high alkyl, aryl, or alkyl aryl carbonates. Fiber- and film-forming polycarbonates are produced by transesterifying dialkyl, dicycloalkyl, or diaryl carbonates with alkyl, cycloalkyl, or aryl dihydroxy compounds (62). [Pg.43]

Paraxanthine—see Xanthine, 1,7-dimethyl-Parent name nomenclature, 1, 35 Parham cycloalkylation in chroman synthesis, 3, 783 Paromomycins as pharmaceuticals, 1, 154 Partial charge transfer from donor to acceptor stacks, 1, 350 Pasteurellosis... [Pg.737]

Oxidation (low yield) of aryl or cycloalkyl methyl groups to aldehydes with chromyl chloride... [Pg.112]

Cycloalkyl esters have.been used to protect the /3-CO2H group in aspartyl peptides to minimize aspartimide formation during acidic or basic reactions. Aspartimide foimation is limited to 2-3% in TFA (20 h, 25°), 5-7% with HF at 0°, and 1.5-4% TfOH (thioanisole in TFA). Cycloalkyl esters are also stable to Et3N, whereas use of the benzyl ester leads to 25 % aspartimide formation during Et3N treatment. Cycloalkyl esters are stable to CF3COOH, but are readily cleaved with HF or TfOH. - ... [Pg.247]

The present preparation illustrates a general and convenient irethod for ring contraction of cyclic ketones. The first step is the usual procedure for the preparation of enamines. The second step involves 1,3-dipolar cycloaddition of diphenyl phosphorazidate to an enamine followed by ring contraction with evolution of nitrogen. Ethyl acetate and tetrahydrofuran can be used as a solvent in place of toluene. Pyrrolidine enamines from various cyclic ketones smoothly undergo the reaction under similar reaction conditions. Diphenyl (cycloalkyl-1-pyrrolidinylmethylene)phosphoramidates with 5,6,7, and 15 members in the ring have been prepared in yields of 68-76%. [Pg.194]

Dimethyl sulfoxide reacts with trifluoroacetic anhydride at low tempera ture to give a complex that is an efficient reagent for the oxidation of alcohols to carbonyl compounds [40 41] This reagent can be used to oxidize primary and secondary aliphatic alcohols, cycloalkyl alcohols, and allylic, homoallylic, ben-zylic, acetylenic, and steroidal alcohols (equation 19)... [Pg.948]

When the ring contains fewer carbon atoms than an alkyl group attached to it, the compound is nfflned as an alkane, and the ring is treated as a cycloalkyl substituent ... [Pg.77]

At higher temperatures the mixture of 10 and methyl vinyl ketone yields the 1,4-carbocyclic compound as described previously. Methyl isopropenyl ketone (5), ethyl acetylacrylate (d), 2-cyclohexenone (21), and 1-acetyl-1-cyclohexene (22) also undergo this type of cyclization reaction with enamines at higher temperatures. This cycloalkylation reaction occurs with enamines made of strongly basic amines such as pyrrolidine, but the less reactive morpholine enamine combines with methyl vinyl ketone to give only a simple alkylated product (7). Chlorovinyl ketones yield pyrans when allowed to react with the enamines of either alicyclic ketones or aldehydes (23). [Pg.216]

Stereochemical positioning of a functional group, relative to a separate enamine moiety in the same molecule, can be done in such a manner that a simple intramolecular alkylation or acylation will cause cyclization. Such intramolecular cycloalkylations with alkyl halides have been reported 107,108). Inftamolecular cycloacylations of enamines with esters 109, 110,110a) and with nitriles 110a,l 11,111a) have also been observed. [Pg.233]


See other pages where Cycloalkylations is mentioned: [Pg.156]    [Pg.801]    [Pg.270]    [Pg.149]    [Pg.552]    [Pg.393]    [Pg.315]    [Pg.478]    [Pg.225]    [Pg.242]    [Pg.429]    [Pg.115]    [Pg.124]    [Pg.184]    [Pg.27]    [Pg.79]    [Pg.794]    [Pg.413]    [Pg.23]    [Pg.38]    [Pg.38]    [Pg.114]    [Pg.539]    [Pg.949]    [Pg.951]    [Pg.214]   


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9- Cycloalkyl

9- Cycloalkyl

Acetals of Ring-Contracted Cycloalkyl Aldehydes

Activated Alkyl and Cycloalkyl Halides

Alcohols cycloalkyl

Alkyl Cycloalkyl Ethers

Alkyl and Cycloalkyl Cyclopropanes

Alkyl and Cycloalkyl Halides

Alkyl, Cycloalkyl, Aralkyl and Related Acids

Alkyl-cycloalkyl

Amines cycloalkyl

Bromides, Alkyl and Cycloalkyl Halides

Butyric acid, a-haloaryl esters cycloalkylation

Carbanions cycloalkyl

Carbenes cycloalkyl

Carboxylic acids cycloalkylation

Cyclic, from cycloalkyl

Cycloalkyl 2-propyl

Cycloalkyl Ammonium

Cycloalkyl aryl

Cycloalkyl aryl sulphones

Cycloalkyl aryl-substituted

Cycloalkyl bromides

Cycloalkyl bromides, reaction

Cycloalkyl carbenium ions

Cycloalkyl cations

Cycloalkyl compounds

Cycloalkyl fluorides

Cycloalkyl halides

Cycloalkyl ions

Cycloalkyl nitrates

Cycloalkyl radicals

Cycloalkyl shifts 204

Cycloalkyl substituents

Cycloalkyl tertiary

Cycloalkylation

Cycloalkylation

Cycloalkylation 4 + 4] Cycloaddition reactions

Cycloalkylation Friedel-Crafts reaction

Cycloalkylation aniline

Cycloalkylation arenes

Cycloalkylation carboxylic acid derivatives

Cycloalkylation intramolecular

Cycloalkylation lactone synthesis

Cycloalkylation nitrogen

Enolates cycloalkylation

GeR4 Compounds with R Cycloalkyl

Generation of Alkyl and Cycloalkyl Carbenes

Intramolecular cycloalkylation in -amjitrienol synthesis

Intramolecular cycloalkylation synthesis

O -alkyl/cycloalkyl

Of cycloalkyl halides

Oxygen cycloalkylation

Parham cycloalkylation

Phenols cycloalkylation

Poly(cycloalkyl methacrylates)

Saturated cycloalkylation

Subject cycloalkylation

Sulfides, cycloalkyl phenyl

Sulfides, cycloalkyl phenyl synthesis

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