Substituents cycloalkyl

When the ring contains fewer carbon atoms than an alkyl group attached to it, the compound is nfflned as an alkane, and the ring is treated as a cycloalkyl substituent ... 

The presence of cycloalkyl substituents in the 2,6-positions of the aryl groups (5q) has been found to increase the temperature stability of the iron catalysts over their alkyl analogues (e.g., 5b or 5c) these results are further supported by a quantum mechanical study [39],... 

The electronic effects of cycloalkyl annelation can be divided into inductive and resonance effects. Few measurements of the resonance contributions of cycloalkyl substituents exist. A single determination of the resonance parameter para to substitution in o-xylene, tetralin and indan suggests that hyperconjugative release is fairly constant within a series of benzocycloalkenes, and that strain induced electronic effects must act inductively. ... 

When the number of carbons in the ring is greater than or equal to the number of carbons in the longest chain, the compound is named as a cycloalkane. However, if an alkyl chain of the cycloalkane has a greater number of carbons, then the alkyl chain is used as the parent, and the cycloalkane as a cycloalkyl substituent. 

Scheme 11 Synthesis of f32-3-Peptides Bearing Cycloalkyl Substituents 29 ...

Alkyl and cycloalkyl substituents seem to have little effects on the geometry of the cyclopropane ring. There are hardly any reliable data on ring distortion in simple molecules. Recent studies have concentrated on highly strained structures (Table 2). 

When the acyclic portion of the molecule contains more carbon atoms than the cyclic portion (or when it contains an important functional group), the cyclic portion is sometimes named as a cycloalkyl substituent. 

The influence of the cyclohexane ring on the glass transition temperature and sub-Tg transitions has been studied by dynamic mechanical methods [10,16,42]. These comparative studies have focused on the influence of the cyclohexyl substituent on observed thermal transitions. A systematic study of cycloalkyl substituents on alternating carbons of a polyethylene backbone was performed to study the influence of these substituents on the dynamic mechanical spectra of the polymers [42], These workers also prepared materials in which the cycloalkyl substituents were spaced away from the polymer backbone by successively longer methylene chains, testing the influence of ring proximity... 

The cyclopentyl substituent was also expanded to cyclohexyl and cycloheptyl. The cycloalkyl substituent provides an important lipophilic interaction, which makes a significant contribution to the affinity. Similar substituents in MK0591 that may correspond with this key lipohilic interaction include the t-butylthiol group or the 4-chlorobenzyl substituent. Stereoselective effects were observed, the R enantiomers displaying a greater affinity for human FLAP. Modification of cyclopentyl to a cycloheptyl alkyl substituent and modification of the acid to a... 

Employing such new synthetic methodologies made it possible to synthesize highly substituted and stereochemically defined ligands, and hence made it possible to probe the effect that substituents exert on the stability and catalytic activity. For these studies we employed both methyl and fused-cycloalkyl substituents on the... 

Table 6.4. chemical shifts of amines containing a cycloalkyl substituent... 

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