Saturated cycloalkylation

In Method 2, described by Rule A-31, the saturated cyclic parent is named as a polycyclo-[.. jalkane. The alkane name identifies the total number of carbon atoms in the ring system. The names bicyclo, tricyclo, tetracyclo, etc. identify parent compounds of two, three, four, etc. rings. Double bonds in the ring are identified by names such as w-alkenc, ,/w-alkadicne, where the n and m give the position of the double bond. Substituents consist of alkyl, cycloalkyl, phenyl, etc. radicals. 

Saturated heteroatomic systems Alkyl sulfides Cycloalkyl sulfides Alkyl side chains on ring systems... 

Azine approach. Partially saturated isoxazolo[3,2-6][l,3]benzoxazines (83) are of interest as antiinflammatory agents. They can be synthesized from 2-hydroxybenzohydroxamic acids and ,/3-unsaturated carbonyl compounds the last step involves simple cycloalkylation of the intermediate fV-oxide (82) (77AF760). 

In addition to ( )-valerane, a wide variety of other sesquiterpenes, including ( )-ishwarane, ( )-ish-warone, ° copaene, ylangene, ( )-seychellene ( )-sativene, ( )-longifoline, " ( )-copa-camphene," ( )-damsin," ( )-A < >-capnellene, ( )-pentalenene, (-)-P-vetivone" and ( )-P-eudesmol have been synthesized by pathways involving cycloalkylation of saturated ketone enolates. 

In contrast to intermolecular processes, intramolecular alkylations are frequently performed with f-BuOK in various solvents. In eqs 6 and 7 are shown examples of endo- and exo-cycloalkylations of cyclic saturated ketones which lead to new five-membered rings. ... 

In addition, during the course of recent mechanistic studies, new methodology for the functionalization of saturated hydrocarbons based on Gif-type protocol has been invented. These reactions are of interest as mechanistic probes and also from the point of view of synthetic utility. Thus, cycloalkanes are transformed with vaiying efficiency into mono-substituted cycloalkyl derivatives (chlorides, bromides, azides, cyanides, thiocyanates, dicycloalkyl sulfides, or nitroalkanes) by conducting iron or copper catalyzed reactions in the presence of alkali metal salts (scheme). 

Ciba Geigy 1981 R, R2 saturated or unsaturated alkyl,cycloalkyl R3 Halogen, alkoxy, nitro,CF3 n 0-3... 

A tridentate phosphine-diamine ligand 96 together with [IrCl(COD)]2 constituted an efficient catalyst system for TH of cycloalkyl and saturated heterocyclic ketones with propan-2-ol at room temperature [90]. For instance, cyclohexyl phenyl ketone was reduced using 0.1 mol% of the in situ-formed iridium catalyst reaching a 94 % conversion in 30 min and giving the corresponding alcohol in 95 % ee. 

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