Cycloalkylation carboxylic acid derivatives

Prior to our work, fluorenones had been synthesized by methods characterized by the limited accessibility of the starting substrate [28,30,32,33] (substrate being fluorene, biphenyl-1-carboxylic acid, benzophenone, fluoranthene, cyclohexene, phenanthrene or phenylpropionic acid derivatives), a lack of stereoselectivity [28,29,31,33] and poor yields. We therefore developed a simple methodology for synthesizing fluoren-9-ones via domino acylation-cycloalkylation/alkylation-cycloacylation (Chart-19). 

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