Tissue adhesives cyanoacrylate

Cyanoacrylate tissue adhesives, in particular iso-or n-buty 1-cyanoacrylate preparations, are suitable for use in the repair of small ulcers and partial-thickness corneal wounds where there is... 

OPHTHALMIC GLUE Cyanoacrylate tissue adhesive (isodent, dermabond, msTOACRYL), while not FDA approved for the eye, is widely used in the management of corneal ulcerations and... 

Shalaby, S. W., Polyester/Cyanoacrylate Tissue Adhesive Formulations, U.S. Patent (to Poly-Med, Inc.) 6,299,631, 2001. 

Goatskin Model A layer of paraffin wax was molded into the bottom of polypropylene containers. The goatskin was dissected from the subcutaneous tissue, stretched to its original dimensions, and pinned onto the wax layer. The container was then filled with a saline solution (0.9% w/vol. NaCl and 0.05% w/vol. NaNg) until the skin was totally submerged. The sample was stored in a freezer at -10°C. Prior to use, the sample was removed from the freezer and thawed at room temperature. The saline was poured from the container. A lint-free tissue was used to remove excess moisture. A 19-cm incision was made down the length of the sample. The skin around the incision was approximated and 400 pL of a cyanoacrylate tissue adhesive... 

Development of absorbable cyanoacrylate tissue adhesives with comparable or superior properties to their clinically accepted, nonabsorbable coxmter-parts, presents a milestone in sutureless woxmd repair. As was the case in the suture area, the absorbable tissue adhesives are expected to replace their non-absorbable coxmterparts in their most important topical applications. Moreover, the absorbable tissue adhesives, and not the non-absorbable ones, are expected to be used for infernal wound repairs. This is provided thaf a practical sterilization method is developed to achieve product sterility. 

Shalaby S. W., Linden, C. L., Jr. and Shalaby M., Absorption of radiolabeUed methoxypropyl cyanoacrylate tissue adhesive composition in rats, Trans. Soc. Biomater., 26, 293, 2003. 

Trimethylene carbonate (TMC) and glycolide (G) were purchased from Boehringer Ingelheim Chemicals, Inc. (Virginia). Polyethylene glycol-400 (PEG-400) was purchased from Sigma-Aldrich (Missouri). Modified/stabilized methoxypropyl cyanoacrylate tissue adhesive (MS-MPC) was prepared at Poly-Med, Inc. (South Carolina). 

Methoxypropyl cyanoacrylate tissue adhesive (C-TA) as a positive control... 

Ideally, a knot should not only be secure but also small. One way to achieve this objective is to couple the energy from an auxiliary source with the restraint obtained from the mechanical interlacing of a small knot. In limited work involving thermal energy from a CO2 laser or chemical energy from a cyanoacrylate tissue adhesive, it has been shown that the KHF of a small (two- or three-throw) knot could be enhanced. While benefits were noted in most materials, in some they tended to be optimum. As knot security and strength continue to be very important parameters in sutures, further work using techniques such as these should be pursued. 

Greenhill GA, O Regan B. Incidence of hypertrophic and keloid scars after N-butyl 2-cyanoacrylate tissue adhesive had been used to close parotidectomy wounds a prospective study of 100 consecutive patients. Br J Oral Maxillofac Surg 2009 47(4) 290-3. 

Larval Arizona tiger salamanders (Ambystoma tigrinum nebulosum) can discriminate between kin and nonkin (Pfennig et al. 1994). In experimental tests, cannibalistic morphs may prey preferentially on unrelated individuals over related ones. The sensory basis for this discrimination was examined by covering the nares of test animals with Vetbond (3M Animal Care Products), an w-butyl cyanoacrylate tissue adhesive. This material blocks the passage of water over the nasal epithelium. In tests, some animals had their nares blocked, while sham controls had the adhesive placed between their nares. Larvae whose nares were blocked consumed kin and nonkin randomly. Animals without their nares blocked consumed more nonkin than kin. These results suggest that discrimination is based on chemical cues. 

Quinn JV (2005) Clinical approaches to the use of cyanoacrylate tissue adhesives. In Quinn JV (ed) Tissue adhesives in clinical medicine, 2nd edn. BC Decker, Hamilton, pp 27—76... 

Woodward SC, Herrmann JB, Cameron JL, Brandes G, Pulaski EJ, Leonard F (1965) Histotoxicity of cyanoacrylate tissue adhesive in the rat. Ann Surg 162 113-122 Yu M, DemingTJ (1998) Synthetic polypeptide mimicsof marine adhesives. Macromolecules 31 4739-4745... 

The adhesive used was n-butyl-2-cyanoacrylate tissue adhesive skin sutures were done with monofilament nylon, and subcutaneous sutures were done with braided absorbable suture. Values are log 10 conversions of CFU per gram of tissue. 

Maw JL, Quinn JV. Cyanoacrylate tissue adhesives. Am J Cosmetic Surg. 1997 14 413-416. 

Guidance for Industry and FDA Staff Class II Special Controls Guidance Document Tissue Adhesive for the Topical Approximation of Skin. Issued May 30, 2008. Supersedes Cyanoacrylate Tissue Adhesive for the Topical Approximation of Skin — Premarket Approval Applications (PMAs), dated February 13, 2004 (issued on July 3, 2007), contact George J. Mattamal, Ph.D., at 240-276-3619 or by email at george.mattamal fda.hhs.gov. 

Howell JM, Bresnahan KA, Stair TO, Dhindsa HS, Edwards BA. Comparison of effects of suture and cyanoacrylate tissue adhesive on bacterial counts in contaminated lacerations. Antimicrob Agents Chemother. 1995 559-560. 

Some of the manufacturers of cyanoacrylate tissue adhesives are listed below ... 

Cyanoacrylate tissue adhesives can be used in lieu of sutures in a number of surgical procedures contributing to make the recovery easier and more comfortable [32]. They include ... 

In this study [48], the effects of closing lacerations with suture or cyanoacrylate tissue adhesive on staphylococcal counts in inoculated guinea pig lacerations were investigated. Wounds closed with adhesive alone had lower counts than did wounds containing suture material (P <0.05). The results of a time-kill study were consistent with a bacteriostatic adhesive effect of the adhesive against S. aureus. 

Another paper [57] presents the results of an experimental study of small arterial anastomosis, combining suture with the cyanoacrylate tissue adhesive. At the distal end of the vessel, two parallel incisions were made, 180° apart... 

These wounds and incisions have been traditionally closed with sutures, staples, or surgical tapes, and more recently, tissue adhesives. An ideal wound closure device should be user friendly, quick, pain free and result in excellent cosmesis, without device removal requirement, and of course be cost-effective [87]. None of the current closure devices possesses all of these requirements. Topical cyanoacrylate tissue adhesives, however, have a number of the characteristics of an ideal wound closure device. 

Some effort has been expended trying to adapt the cyanoacrylate tissue adhesives in methyl cyanoacrylate, to dentistry as sealants, coatings and adhesives (14). Thus far there has been no practical application. 

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