Cough pneumonitis

Symptoms Ulceroglandular disease involves a necrotic, tender ulcer at the site of inoculation, along with tender, enlarged regional lymph nodes. Fever, chills, headache, and malaise often accompany such symptoms. Systemic and pneumonic forms usually involve serious unproductive cough, abdominal pain, generalized muscle pain as well as prolonged fever, chills, and headache. 

Plague. Clinical features of pneumonic plague include fever, cough with muco-purulent sputum (gram-negative rods may be seen on gram stain), hemoptysis, and chest pain. A chest radiograph will show evidence of bronchopneumonia. 

With pneumonic plague, the first signs of illness are fever, headache, weakness, and rapidly developing pneumonia with shortness of breath, chest pain, cough, and sometimes bloody or watery sputum. The pneumonia progresses for 2 to 4 days and may cause respiratory failure and shock. Without early treatment, patients may die. 

In a biological warfare scenario, the plague bacteria could be delivered by contaminated fleas (bubonic plague) or, more likely, by aerosol spread (pneumonic plague). Pneumonic plague can be transmitted also by large aerosol droplets expelled by coughing. 

Q79 As opposed to flecainide, amiodarone is not associated with pneumonitis as a side-effect. Signs of pneumonitis include progressive shortness of breath or cough. 

In humans, 10 ppm is intolerable, causing severe irritation of tbe upper respiratory tract lacrimation occurs at levels below Ippm. Symptoms and signs in humans also include dizziness, headache, epistaxis, and cough, followed some hours later by abdominal pain, diarrhea, and sometimes, a measleslike eruption on the face, trunk, and extremities. Exposure at 40-60 ppm is thought to cause pneumonitis and pulmonary edema within a short time, and 1000 ppm may be rapidly fatal because of choking caused by edema of the glottis and because of pulmonary edema. ... 

Mild mucous membrane irritation may occur at 0.2-16 ppm eye irritation occurs at 7-8 ppm, throat irritation at 15 ppm, and cough at 30ppm. Toxic pneumonitis and pulmonary edema can be expected at 40-60 ppm. A level of 430 ppm is lethal after 30 minutes, and 1000 ppm is fatal after a few deep breaths. Other studies have shown that at least some subjects develop eye irritation, headache, and cough at concentrations as low as 1-2 ppm. 

Concentrations of 10 ppm can be withstood for only a few minutes profuse lacrimation occurs in all subjects, even those acclimated to lower levels. Between 10 and 20 ppm, it becomes difficult to take a normal breath burning of the nose and throat becomes more severe and extends to the trachea, producing cough. On cessation of exposure, the lacrimation subsides promptly, but tbe nasal and respiratory irritation may persist for about an hour. It is not known at which levels serious inflammation of the bronchi and lower respiratory tract would occur in humans it is expected that 5- or 10-minute exposures to levels of 50-100 ppm would cause very serious injury. Acute irritation of the human respiratory tract from inhalation of high levels of formaldehyde has caused pulmonary edema, pneumonitis, and death. ... 

Inhalation of manganese tetroxide dust can lead to an inflammatory response in the lung. Symptoms may include cough, bronchitis, pneumonitis, and occasionally pneumonia. It has been noted that this type of inflammatory... 

Selenium dusts produce respiratory tract irritation manifested by nasal discharge, loss of smell, epistaxis, and cough. A group of workers briefly exposed to unmeasured but high concentrations of selenium fume developed severe irritation of the eyes, nose, and throat, followed by headaches. Transient dyspnea occurred in one case. Workers exposed to an undetermined concentration of selenium oxide developed bronchospasm and dyspnea followed within 12 hours by metal fume fever (chills, fever, headache) and bronchitis, leading to pneumonitis in a few cases all were asymptomatic within a week. ... 

The third condition, late respiratory systemic syndrome, is characterized by cough, mucus production, occasional wheezing, and systemic symptoms of malaise, chills, fever, and aching muscles and joints, occurring 4—12 hours alter exposure. This syndrome also has been termed TMA flu and clinically resembles hypersensitivity pneumonitis with visible chest X-ray infiltrates. High levels of IgG serum antibody and total serum antibody directed against trimellityl-human protein conjugates accompany the syndrome, and a latent period of exposure before the onset of symptoms is typical. 

Pulmonary - Pulmonary symptoms (especially a dry, nonproductive cough) or a nonspecific pneumonitis indicate a potentially dangerous lesion and require interruption of treatment and careful investigation. The typical patient presents with fever, cough, dyspnea, hypoxemia, and an infiltrate on chest x-ray. 

Serious, potentially fatal pulmonary toxicity (alveolitis, pulmonary fibrosis, pneumonitis, acute respiratory distress syndrome) may begin with progressive dyspnea and cough with crackles, decreased breath sounds, pleurisy, CH F, or hepatotoxicity. 

Time weighted average (TWA) 300 ppm shortterm exposure limit (STEL) 500 ppm Mildly toxic by inhalation. Human systemic effects by inhalation include coughing, eye irritation, hallucinations, and poor perception. Prolonged skin exposure can cause dermatitis and blistering of the skin. Prolonged inhalation of vapors can result in depression of the central nervous system. Aspiration can cause severe pneumonitis. 

Kerosene is a suspected carcinogen. Ingestion can result in coughing, vomiting, fever, hallucinations, and poor perception. Aspiration can result in severe pneumonitis. 

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