Connective tissue proliferation

Chronic therapy with methysergide was associated with connective tissue proliferation in the... 

Stage II The periportal stage presents an encroachment of the inflammatory changes on the parenchyma with piecemeal necrosis connective tissue proliferations also break into the lobule (so-called periportal hepatitis + fibrosis). Liver cell necroses are also found sporadically, whereby CD4 cells, CD56-NK cells and lymphocytes are markedly increased. In places, reduction in and fibrosis of bile ducts are already in evidence, (s. fig. 32.13) (335, 349, 384)... 

Paraquat is selectively taken up and concentrated by pulmonary alveolar cells, leading to cell necrosis followed by connective tissue proliferation and pulmonary fibrosis. 

Vasilief, j. M. The role of connective tissue proliferation in invasive growth of normal and malignant tissues a review. Brit. J. Cancer 12 524-536 (1958). 

While it is difficult to obliterate multiple arteriovenous connections via the feeding arteries, this can be easily achieved by packing the lumen of the single venous channel of the lesion. Although this might induce transient pressure elevation inside the nidus, rupture and bleeding does not occur, as the nidus is located within the dura and is surrounded by thick walls, reinforced by connective tissue proliferation (Houdart et al. 1993). In contrast to brain AVMs, venous occlusion is feasible... 

One of the most interesting aspects of ascorbic acid is its role in hydroxyproline synthesis (see Fig. 4-17). Connective tissue grows subcutaneously in polyvinyl sponge implants. Ascorbic acid causes rapid growth of the connective tissue under those conditions, and connective tissue proliferation is associated with a rapid incorporation of hydroxyproline. 

The appearance of nerve roots is similar to that of peripheral nerves. In addition to partial demyelination there is extensive connective tissue proliferation. Blood vessels of the spinal cord may appear hyaline and the vessel wall shows increased eosinophilia (Reese and Bareta 1950). 

Estrogens stimulate cellular proliferation, induce RNA and protein synthesis of uterine endometrium and the fibrous connective tissue framework for ovaries, and increase the size of the cells. This effect leads to the growth and regeneration of the endometrial layer and spinal arterioles, and increase in the number and size of endometrial glands. Under the influence of estrogen, vaginal mucosa becomes thicker, as cervical mucus becomes thinner (85,86). 

PDGF Isoforms consist of homo- and heterodimers of A- and B-polypeptide chains and homodimers of C- and D-polypeptide chains PDGFR Consists of PDGFR a and (3 receptors Embryonic development, particularly in the formation of the kidney, blood vessels, and various mesenchymal tissues. Proliferation of connective tissues, glial and smooth muscle cells... 

EDI), and water to produce a group of biodegradable PU foams. The interconnected pores varied in size from 10 to 2 mm in diameter. Rabbit bone-marrow stromal cells cultured on the materials for up to 30 days formed multilayers of confluent cells and were phenotypically similar to those grown on tissue culture PS. It supported the adherence and proliferation of both bone-marrow stromal cells and chondrocytes in vitro. In subdermal implants the investigators found that the material showed infiltration of both vascular cells and connective tissue. 

Recently, NGF has been shown to cause a significant proliferation of connective tissue mast cells when injected subcutaneously into newborn (day 1) rats [122]. This effect of NGF is blocked by DSCG, which suggests that products released from NGF-stimulated mast cells are responsible (directly or indirectly) for the proliferation or recruitment of other mast cells. In adult rats, a similar proliferation of mucosal mast cells in the small intestine is known to accompany an infection by intestinal nematode, N. brasilensis [123] and has also been reported to accompany the repeated injections of compound 48/80 [ 124], It may be relevant in this regard that mast cells are frequently prominent in a wide variety of fibrotic conditions such as neurofibromatosis where itching around the growing neurofibroma is a common symptom [125]. Treatment of neurofibromatosis with ketotifen, a mast cell stabilizer similar to DSCG, results... 

Cancer is a disease characterised by uncontrolled proliferation of cells that produces a tumour, from which the cells can invade local tissues and then spread to give rise to metastases. Cancers are classified into three groups carcinomas, sarcomas and leukaemias/lymphomas. Carcinomas, the most common, arise in epithelial cells, sarcomas in connective tissue (e.g. bone, cartilage) and leukaemias and lymphomas from white blood cells. 

The atherosclerotic plaque consists, on the lumen side, of a layer of connective tissue containing smooth muscle cells and macrophages covering a deeper layer of macrophages containing so much hpid that they are known as foam cells due to their microscopic appearance. This layer also contains a varying amount of cell debris and extracellular lipid. Outside it, there is often a region of proliferated smooth muscle cells. 

The test of BASYC tubes as small-vessel prosthesis for other artificial pipehnes (arteries, veins, lymph, and urine leading vessels) is under progress. Initial results of the implantation of BASYC material into jugular veins of 10 white rats showed no complications such as wall-proliferation, stenosis or thrombosis. A normal blood flow through the interposition as well as the formation of connective tissue around it were detectable 4 and 12 weeks, respectively, after the operation [124]. 

In common with all epithelial interfaces (see Section 1.3.2), the epithelium of the oral cavity is supported by a basement membrane, which separates the epithelium from the underlying connective tissue layer (the lamina propria) (Figure 7.1). Oral epithelium is broadly similar to stratified squamous epithelia found elsewhere in the body, for example the skin (see Section 8.2.1), in that cells are produced by mitosis in the basal layer of the epithelium and these proliferating cells push existing cells towards the surface. The phases of this dynamic process are represented in four morphological layers ... 

---