Nitric oxide signalling

Garthwaite, J. and Boulton, C. Nitric oxide signaling in the central nervous system. Ann. Rev. Physiol. 57 683-706,1995. 

K. Dvorakova, H. Bernstein, C. Bernstein, H. Holubec and H. Garewal, Caspase-6 mediated cleavage of guanylate cyclase alpha 1 during deoxycholate-induced apoptosis protective role of the nitric oxide signalling module. Cell Biol. Toxicol, 2003, 19(6), 373. 

Lander, H. M., Sehajpal, P. K., and Novogrodsky, A. (1993b). Nitric oxide signaling A possible role for G proteins. J. Immunol. 151, 7182-7187. 

Epidemiologic, experimental, and in vitro mechanistic data indicate that lead exposure elevates blood pressure in susceptible individuals. In populations with environmental or occupational lead exposure, blood lead concentration is linked with increases in systolic and diastolic blood pressure. Studies of middle-aged and elderly men and women have identified relatively low levels of lead exposure sustained by the general population to be an independent risk factor for hypertension. In addition, epidemiologic studies suggest that low to moderate levels of lead exposure are risk factors for increased cardiovascular mortality. Lead can also elevate blood pressure in experimental animals. The pressor effect of lead may be mediated by an interaction with calcium mediated contraction of vascular smooth muscle, as well as generation of oxidative stress and an associated interference in nitric oxide signaling pathways. 

Xu Y. and Tao Y. X. (2004). Involvement of the NMDA receptor/nitric oxide signal pathway in platelet-activating factor-induced neurotoxicity. NeuroReport 15 263-266. 

Hopper RA, Garthwaite J (2006) Tonic and phasic nitric oxide signals in hippocampal long-term potentiation. J Neurosci 26 11513-21... 

Riccio A, Alvania RS, Lonze BE, Ramanan N, Kim T, Huang Y, Dawson TM, et al. (2006) A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol Cell 21 283-94... 

Delledonne, M., Murgia, I., Ederle, D., Sbicego, P.F., Biondani, A., Polverari, A. and Lamb, C., 2002, Reactive oxygen intermediates modulate nitric oxide signaling in the plant hypersensitive disease-resistance response. Plant Physiol. Biochem. 40 605-610. 

Baker PRS, Lin Y, Schopfer FJ, Woodcock SR, Groeger AL, Batthyany C, Swooney S, Long MH, lies KE, Baker LMS, Branchaud BP, Chen Y, Freeman BA. Fatty acid transduction of nitric oxide signaling Multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands. J. Biol. Chem. 2005 280 42464-42475. 

Wright MM, Schopfer FJ, Baker PRS, Vidyasagar V, Powell P, Chumley P, lies KE, Freeman BA, Agarwal A. Fatty acid transduction of nitric oxide signaling Nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression. Proc. Natl. Acad. Sci. U.S.A. 2006 103 4299-4304. 

Figure 1 Nitric oxide signal transduction pathway. NO synthesized by NOS diffuses across cell membranes to a target cell. NO activates sGC, which leads to an increase in cCMP synthesis. The oxidation products of NO also can react with protein thiols, which leads to protein S-nitrosation.

Cary SP, Winger JA, Marietta MA. Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP. Proc. Natl. Acad. Sci. U. S. A. 2005 102 13064-13069. 

Harteneck C, Wedel B, Koesling D, Malkewitz J, Bohme E, Schultz G. Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme. FEES Lett. 1991 292 217-222. Cary SP, Winger JA, Derbyshire ER, Marietta MA. Nitric oxide signaling no longer simply on or off. Trends Biochem. Sci. 2006 31 231-239. 

Ding H, Demple B. Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers in the SoxR transcription activator. P. Natl. Acad. Sci. 2000 97 5146-5150. 

Murad E 1998. Nitric oxide signalling would you believe that a simple free radical could be a second messenger, au-tacoid, paracrine substance, neurotransmitter, and hormone Rec. Prog. Norm. Res. 53 43-60... 

Godfrey EW, Schwarte RC. 2003. The role of nitric oxide signaling in the formation of the neuromuscular junction. J Neurocytol 32 591-602. 

Puttmann B, Gerlach EM, Kruger M, Blottner D. 2005. Neuromuscular contacts induce nitric oxide signals in skeletal myotubes in vitro. Neurosignals 14 85-95. 

Lu Y-F, Kandel ER, Hawkins RD (1999) Nitric oxide signaling contributes to late-phase LTP and CREB phosphorylation in the hippocampus. J Neurosci 19 10250-10261... 

I. MECHANISMS OF NITRIC OXIDE SIGNALING IN VASCULAR CELLS... 

---