PMMA coating

Figure 7.7 Abrasion resistance (haze) dependence on GPS A1(OBu)3 molar ratio for hybrid-coated PMMA surfaces compared to uncoated PMMA. PMMA substrate is corona treated followed by a 2.5% 3-aminopropyl-triethoxysilane treatment prior to the application of GPS Al(OBu)3 hybrid solutions. Coating thickness 4 mm coatings were cured at 80 °C for 4 h. (Reproduced from ref. 5, with permission.)...

Surface-plasmon resonance (SPR) has been used to detect surface-bound chemical species. SPR is achieved to detect the binding events of antibody and antigens in immunoassays. A gold-coated PMMA chip that was sealed by a PDMS channel plate was used. The antibodies were first immobilized on the gold layer. Upon binding with benzo[a]pyrene (BaP) 2-hydroxybiphenyl (HBP), the SPR signal was recorded [740]. 

Inserted emitter, silver glue coated, PMMA chip ESI-ITMS BSA, fibrinopeptide A, osteocalcin fragment 7-19, bradykinin (all 10 pmol/jxL) Trypsin, off-chip Nil 814... 

Recently spin-coated PMMA thin films with a thickness of 0.45 pm on silicon wafer were irradiated with various ion beams (H+, He+, N+, Ni3+). Ion beam energy regions are from 300 keV to 4 MeV. Irradiated PMMA films were developed by isopropyl alcohol in these experiments. After the irradiation by ion beams on PMMA in a vacuum, the thickness of the films were measured both before and after development. Various radiation effects on PMMA films such as ablation (sputtering), main chain scission, and positive-negative inversion were observed as shown in Fig. 11. These phenomena are very different from those in 60 Co gamma-ray or electron beam irradiation. Large LET effects are considered to be due to high density excitation by ion beams. 

Figure 833 SEM images of (a) Silver coated PMMA tnicrosphere (b) Si02/Fc304 microspheres.

The difference between these two models could be due to the acid-base interactions established between OH grafts and PMMA chains during evaporation of the solvent (spin-coating) PMMA blocks will be attracted to the OH grafts and thus will be more flattened on the functionalized gold interface, while the PCL chains implied in the crystalline phase are less mobile and are not able to establish such interactions. 

B. Dick, K. Greiner, G. Magdowski, N. Pfeiffer, Long term stability of heparin coated PMMA intraocular lenses. Results of an in vivo study, Ophthalmologe 94 (12) (1997) 920-924. 

Low angle tape peel Spin coat PMMA (3000 RPM. 1 min). Bake sample at 150 °C for 2 min. Repeat once. 

Verret, V., Wassef, M., Pelage, J.P., Ghegediban, S.H., Jouneau, L., Moine, L., et al., 2011. Influence of degradation on inflammatory profile of polyphosphazene coated PMMA and trisacryl gelatin microspheres in a sheep uterine artery embolization model. Biomaterials 32 (2), 339—351. 

Cui and Li (2000) also studied platelet interaction with DLC-coated polymethylmethacrylate (PMMA) intraocular lenses and uncoated PMMA intraoccular lenses (lOLs). Their result showed that DLC-coated PMMA-lOLs had lower platelet adhesion compared with the uncoated sample (Cui and Li, 2000). 

Based on their study of neutral granulocyte—neutrophil interaction with DLC (obtained by IBAD technique) coated PMMA lOLs, Li et al. (1999) reported that DLC-coated PMMA lOLs exhibit lower neutrophil adhesion compared with uncoated PMMA lOLs. 

Cui and Li (2000) also studied the adhesion of plasma proteins on DLC-coated, CN-coated PMMA and uncoated PMMA using radioactive targeted proteins. They reported an albumin/fibrinogen ratio of 1.008 for DLC, 0.49 for CN and 0.39 for PMMA (Cui and Li, 2000). 

Chitosan act as excellent carrier in acting as carrier for poor soluble drugs. Among the various pharmaceutical applications, chitosan significantly plays an important role in improving the bioavailability and solubility of various drugs e.g. thiolated chitosan-coated pMMA NPs were prepared to improve the bioavailability and solubility of paclitaxelon different normal and cancer cell lines [186]. 

Akhlaghi SP, Saremi S, Ostad SN, Rassoul D, Atyabi F. Discriminated effects of thiolated chitosan-coated pMMA paclitaxel-loaded nanoparticles on different normal and cancer ceU lines. Nanomed Nanotech Biol Med. 2010 6(5) 689-97. 

Reimer [1121 found a moderate reduction in mass loss rate for coated PMMA. Salih and Cosslett [113] coated an aromatic organic crystal and found that the dose needed to destroy the diffraction pattern increased by five times. Fryer and Holland [114] found factors of three to ten times improvement for a wide range of organic crystals. No reports have been published for diffraction lifetimes from coated polymer films, but with a very simple technique promising significant gains, it is worth a try. 

It is worth mentioning that when the particle volume fraction is high enough, the three-dimensional network structure instead of fibrillated chain structure may form in ER fluids [5]. Sometimes the three-dimensional dendritic structure may form [6-8]. Figure 1 shows the microstructure of a metal/oil, glass sphere/oil, and nickel coated PMMA/oil under an electric field. Both the metal and metal coated PMMA particles form the dendritic structure, and only the glass spheres form the fibrillated chain structure. The appearance of fractal structure is believed to arise from the huge conductivity difference between the dispersed particle and the dispersed medium. 

Figure 1 The microstruclure of particlc/oil suspensions, (a) a mctal/oil (b) glass sphere/oil (c) nickel coated PMMA/oil. PMMA=poIymethyl methacrylate. Reproduced with permission from W. Wen, and K. Lu, Phys. Fluids, 8(1996)2789 W. Wen, and K. Lu, Phys. Fluids, 9(1997)1828.

G. Giavaresi, V. Borsari, M. Fini, R. Giardino, V. Sambri, P. Gaibani and R. Soffiatti, Preliminary investigations on a new gentamicin and vancomycin-coated PMMA nail for the treatment of bone and intramedullary infections An experimental study in the rabbit. 7 Orthop. Res. 26 785-92,2008. 

From the literature, little is known about specific interactions in bacterial adhesion to polymers. In the adhesion of S. sanquis to saliva-coated hydroxyl apatite (HA), the existence of two specific receptor sites on HA could be demonstrated to which sialic acid lectins can bind. Vaudaux, et al., found in adhesion experiments of S. aureus to fibronectin-coated PMMA coverslips, that presumably a specific site in the amino-terminal region of fibronectin is involved in the adhesion process, and that collagen may play a role as an adhesion cofactor. 

Fig. 4,34 Plot of water contact data as a function of the drop size for (a) hydrophilic coated and (b) hydrophobic coated PMMA groove surfaces (top measured in the perpendicular direction, bottom measured in the parallel direction), and (c) width of the grooves in (a) and (b) (Modified from [101], Copyright 2009 The American Chemical Society)...

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