Discrimination effect

Typical decay curves for various ionic masses are shown in Figure 3b, where the effect of differing thermal velocity is clearly evident. Neglect of such decay characteristics can lead to serious discrimination effects. Note that all the experimental curves have the sigmoid shape... 

The intensity changes observed, while consistent with the occurrence of Reaction 1, were small enough to have originated from discrimination effects. A new instrument is being constructed in our laboratory which... 

Reactions involving a transfer of a proton or a hydrogen atom are an extremely common type of ion-molecule reaction and are particularly suited for study by the pulsed source technique. The secondary ion will usually occur at an m/e ratio where it is not obscured by abundant primary ions, and the product and reactant ions frequently will differ only slightly in mass, thus minimizing discrimination effects. 

Holtzman, S.G. Phencyclidine-1ike discriminative effects of opioids in the rat. J Pharmacol Fxp Ther 214 614-619, 1980. 

Kammerer, B., Kahlich, R., Ufer, M., Laufer, S., Gleiter, C. (2005). Achiral-chiralLC/LC-MS/ MS coupling for determination of chiral discrimination effects in phenprocoumon metabolism. Anal. Biochem. 339, 297-309. 

Martin and co-workers (142,143) have found that, in animals, tryptamine produced many of the physiologic effects characteristic of LSD however, it does not appear to elicit behavioral effects similar to those of LSD. At relatively high doses, 5-methoxytryptamine (24) does produce some behavioral effects in rats (66,242) and in nonhuman primates (101). Vogel (242) has suggested that the disruptive effects of 5-methoxytryptamine might be due to the peripheral actions of this agent. Tryptamine had no effect on acquisition of avoidance behavior, whereas 5-methoxytryptamine slightly decreased such behavior (240). Both tryptamine and 5-methoxytryptamine produced discriminative effects in rats... 

Mason TFD, Weiss DJ, Horstwood M, Parrish RR, Russell SS, Mullane E, Coles BJ (2004b) High-precision Cu and Zn isotope analysis by plasma source mass spectrometry. Part 2. Correcting for mass discrimination effects. J Anal At Spectrom 19 218-226... 

The similarities between cathinone and amphetamine raises the possibility of abuse potential (Kalix 1994). Amphetamine and cathinone both appear to produce their stimulus-discrimination effects through the dopamine system (Kalix and Glennon 1986). 

N. V. Lokshin, L.R. Chuprikov, A.V. Discrimination Effects in Inoi anic lon-Cluste Detection by SEM in Mass Spectrometry Experiments. Rapid Commun. Mass Spectrom. 1990,4,9-12. 

The WDMSPR sensor approach offers the benefit of multichannel performance without increasing complexity and costs of the sensor system. In addition, the WDMSPR sensors make it possible to discriminate effects occurring in the proximity of sensor surface (specific binding, non-specific adsorption) from those occurring in the whole medium (interfering background refractive index fluctuations) which is a prerequisite for robust referencing ". ... 

Nicotine discrimination studies have been conducted in humans, squirrel monkeys, rats and mice. However only in humans as there been any systematic approach to examine whether there are sex differences in discriminative effects. Female smokers... 

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