Choroid melanoma

In other case reports, choroidal melanoma was observed in one man who had been exposed to hydrazine for 6 years, and chronic myeloid leukemia was reported in two patients with long-lasting exposure to hydrazine. " ... 

Albert DM, Puliafito CA Choroidal melanoma Possible exposure to industrial toxins. N EnglJ Med 296 634-63 5, 1977... 

As previously summarized, four cases of bronchial carcinoma were reported in men exposed occupationally to dimethyl sulfate (IARC, 1974). Additional case reports have since appeared a case of pulmonary carcinoma in a man exposed for seven years to small amounts of dimethyl sulfate but to larger amounts of bis(chloromethyl)ether and chloromethyl methyl ether (lARC, 1987b), and a case of choroidal melanoma in a man exposed for six years to dimethyl sulfate (IARC, 1987a). 

All patients with anterior uveitis should undergo dilated funduscopy. Such examination should be attempted on the initial visit, although it may be difficult because of patient discomfort and/or posterior synechia. In such cases, ophthalmoscopy on the first follow-up visit may yield more useful information. Without adequate careful examination of the peripheral fundus and posterior pole, one cannot rule out the possibility of posterior involvement or masquerade syndromes. Masquerade syndromes are disorders that present as uveitis but do not have an inflammatory etiology. Such diseases either cause a secondary uveitis or are mistaken for a primary uveitis, because of the presence of white cells, red blood cells, pigment, or tumor cells. Examples of masquerade syndromes may include lymphoma, leukemia, retinoblastoma, malignant choroidal melanoma, retinal detachment, and intraocular foreign body. 

Schmidt-Erfurth U, Bauman W, Gragoudas E, et al. Photodynamic therapy of experimental choroidal melanoma using lipoprotein-delivered benzoporphyrin. Ophthalmology 1994 101 89-99. 

To date, we have analyzed data from 16 patients (seven women, nine men) with a mean age of 59 12 years. The patients presented with various primary tumors including HCC ( = 3), breast cancer ( = 4), colorectal cancer (n = 4), choroid melanoma ( = 2), carcinoid (n = 1), cholangio-cellular carcinoma ( = 1) and pancreatic carcinoma ( = 1). First, metabolically active lesions were identified based on glucose metabolism in... 

Jakobs et al. [35] reported results on 39 treated patients (17 women, 22 men) that included colorectal cancer, metastatic breast cancer, hepatocellular carcinoma, neuroendocrine tumors, and a mixed group composed of metastatic pancreatic cancer, carcinoma of unknown primary, cholangiocellular carcinoma, thymus carcinoma, malignant melanoma, and choroid melanoma. In this mixed tumor group, two patients were lost for follow-up immediately after treatment. Two patients died before first follow-up 3 months after SIRT (one patient with choroid melanoma and one with carcinoma of unknown primary). However, at the first followup 3-4 months after SIRT, five of six patients presented with stable disease or partial response. The same applied for two of three patients at the followup at 5-6 months. Stable disease was noted in two of three patients at 10-11 months after SIRT. The median time to progression was 8 months (range 3-11 months), although two patients were lost and two died before first follow-up and were therefore not included in this analysis. The median survival was 2.2 months. 

Int J Radiat Oncol Biol Phys 19 1071-1075 Tsuji H, Ishikawa H, Yanagi T, et al (2007) Carbon-ion radiotherapy for locally advanced or unfavourably located choroidal melanoma a phase I/II dose-escalation study. Int J Radiat Oncol Biol Phys 67 857-862 Ueno NT, Buzdar AU, Singletary SE, et al (1997) Combined-modality treatment of inflammatory breast carcinoma twenty years of experience at M.D. Anderson Cancer Center. Cancer Chemother Pharmacol 40 321-329 Veyret C, Levy C, Chollet P, et al (2006) Inflammatory breast cancer outcome with epirubicin-based induction and maintenance chemotherapy ten-year results from the French Adjuvant Study Group GETIS 02 trial. Cancer 107 2535-2544... 

Bedikian AY et al. (1981) Prognosis in metastatic choroidal melanoma. South Med J 74 574-577... 

In most instances, cross-sectional imaging will not be required when dealing with diseases of the eyeball. However, retinoblastoma, choroideal melanoma, choroi-... 

Buquicchio R, Foti C, Cassano N, Ventura M, Vena GA. Allergic contact dermatitis from timolol complicating choroidal melanoma-related glaucoma. Eur J Dermatol 2009 19(1) 74-5. 

Krause, M.H., Kwong, K.K., Gragoudas, E.S. and Young, L.H. (2004) MRl of blood volume with superparamagnetic iron in choroidal melanoma treated with thermotherapy. Magnetic Resonance Imaging, 22, 779-87. 

Uveal melanoma is the most common primary intraocular malignancy seen in adults, but is an uncommon tumor. Unlike cutaneous melanoma, the frequency and mortality of uveal melanoma have remained steady. This melanoma arises from the pigmented epithelium of the choroid. Iris melanoma is a subset of uveal melanoma and tends to have a more benign course. The risk of metastasis varies with the histologic type and size of the tumor, as well as the location in the eye. Metastases occur most frequently in the liver, but have been documented in a variety of tissues. 

Bevacizumab has been studied in advanced carcinoid tumors [167 ], prostate cancer [168 ], high-risk corneal transplantation [169 ], diabetic retinopathy [170 , 171, 172 ], ischemic retinal diseases [173 ], refractory choroidal neovascularization secondary to uveitis [174 ], macular edema secondary to branch retinal vein occlusion [175 ], retinal angiomatous proliferation [176% choroidal neovascularization attributable to pathological myopia [177, 178], exudative age-related macular degeneration [179 ], multifocal lymphangioendothe-liomatosis with thrombocytopenia [180" ], in combination with chemotherapy for the treatment of recurrent ovarian cancer [181 j, advanced melanoma [182 ], malignant pleural mesothelioma [183 ],... 

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