Combined modality treatment

Murray N, Coy P, Pater JL, et al. Importance of timing for thoracic irradiation in the combined modality treatment of limited-stage small-cell lung cancer. The National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 1993 ll(2) 336-344. 

Belani CP, Ramanathan RK. Combined modality treatment of locally advanced non-small cell lung cancer Incorporation of novel chemotherapeutic agents. Chest 1998 113(Suppl 1) 53S-60S. 

Combined Modality Treatment of Small-Cell Lung Cancer... 

A Surrogate Endpoint for Survival Combined Modality Treatment in Inflammatory Breast Cancer Concluding Remarks References... 

COMBINED MODALITY TREATMENT IN INFLAMMATORY BREAST CANCER... 

Buzdar AU, Singletary SE, Booser DJ, Frye DK, Wasaff B, Hortobagyi GN. Combined modality treatment of stage III and inflammatory breast cancer. M.D. Anderson Cancer Center experience. Surg Oncol Clin N Am 1995 4 715-734. 

Thomas E, Buzdar A, HortobagyiG, etal. Long-Term Follow Up of Stage III Breast Cancer-Combined Modality Treatment with Anthracycline Containing Chemotherapy (CT) The MD Anderson Experience (Meeting abstract). ProcAnnu Meet Am Soc Clin Oncol 1999 18 A284. 

Hodgkin s disease accounts for 1% of all new cancers diagnosed in Western countries and for 15% of all malignant lymphomas. In patients with early stage lA-IIA disease without B-symptoms or bulky adenopathy, therapy consists of either extended field radiotherapy or limited duration chemotherapy, e.g. ABVD (anthracycline, bleomycin, vinblastine, dacarbazine) for 3-4 cycles followed by involved field radiotherapy. Radiation alone results in a 10-year relapse free survival of 70-75% and, because of the efficacy of salvage chemotherapy for those who relapse, an overall survival of 80-85%. The combined modality approach results in fewer relapses but overall survival is similar. In order to reduce the long term morbidity of radiation current trials are exploring combined modality treatment with lower radiation doses versus chemotherapy alone. 

Oehler C, Ciernik IF. Radiation therapy and combined modality treatment of gastrointestinal carcinomas. Cancer Treat Rev. 2006 32 119-138. 

Loeffler M, Brosteanu O, Hasenclever D, et al. Meta-analysis of chemotherapy versus combined modality treatment trials in Hodgkin s disease. International Database on Hodgkin s Disease Overview Study Group. J Clin Oncol 1998 16 818-829. 

PPF method is capable of producing double-walled micros[4ieres and encapsulating dual agents for combined modality treatment, such as gene therapy and chemother y. 

The available preclinical and clinical data strongly support the introduction of antiangiogenic drugs into combined modality treatment regimens that include radiation therapy. 

The available recent preclinical and clinical data strongly support the introduction of antiangiogenics into combined modality treatment schemes that include radiotherapy. The ultimate benefit of these therapeutic combinations needs to be determined with longer follow-up of the effect of these antiangiogenic agents... 

In order to inactivate a tumor cell, several distinct yet overlapping pathways may be activated. Besides the induction of pure apoptosis, other cell inactivation modalities, including programmed necrosis, mitotic catastrophe, senescence, or terminal differentiation, may be triggered (Belka 2006). The influence of a combined modality treatment on any of these end points has never been analyzed in greater detail thus, only very few data are available showing that the combination of paradigmatic radiation sensitizers with radiation quantitatively alters the induction of certain predefined mechanisms of cell death (Fig. 10.7). 

Fig. 10.7. Mechanisms of chemoradiation on a molecular level. The most prominent points of interaction of radiation with chemotherapy being of importance for the efficacy of a combined modality treatment are found on the level of DNA damage induction and repair, cell death induction, and cell cycle control...

Tannock IF (1989) Combined modality treatment with radiotherapy and chemotherapy. Radiother Oncol 16 83-101 Tannock IF (1992) Potential for therapeutic gain from combined-modality treatment. Front Radiat Ther Oncol 26 1-15... 

Int J Radiat Oncol Biol Phys 19 1071-1075 Tsuji H, Ishikawa H, Yanagi T, et al (2007) Carbon-ion radiotherapy for locally advanced or unfavourably located choroidal melanoma a phase I/II dose-escalation study. Int J Radiat Oncol Biol Phys 67 857-862 Ueno NT, Buzdar AU, Singletary SE, et al (1997) Combined-modality treatment of inflammatory breast carcinoma twenty years of experience at M.D. Anderson Cancer Center. Cancer Chemother Pharmacol 40 321-329 Veyret C, Levy C, Chollet P, et al (2006) Inflammatory breast cancer outcome with epirubicin-based induction and maintenance chemotherapy ten-year results from the French Adjuvant Study Group GETIS 02 trial. Cancer 107 2535-2544... 

Nieder C, Adam M, Grosu AL (2006) Combined modality treatment of glioblastoma multiforme the role of temozo-lomide. Rev Recent Clin Trials 1 43-51 Oltersdorf T, Elmore SW, Shoemaker AR, et al (2005) An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435 677-681... 

Kemeny MM, Adak S, Gray B, et al (2002) Combined-modality treatment for resectable metastatic colorectal carcinoma to the liver surgical resection of hepatic metastases in combination with continuous infusion of chemotherapy an intergroup study. J Clin Oncol 20 1499-1505... 

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