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Genetic heterogeneity

These assays were valuable in the early study of allergy and anaphylaxis. However, the immune response, especially the induction phase of allergy (antibody production), to low weight compounds is genetically restricted. Therefore, when the heterogeneous genetic background of humans is considered, the use of these methods is limited [56],... [Pg.26]

Waldman, I.D., Robinson, B.E, and Feigon, S.A. (1997) Linkage disequilibrium between the dopamine transporter gene (DATl) and bipolar disorder extending the transmission disequilibrium test (TDT) to examine genetic heterogeneity. Genet Epidemiol 14(6) 699-704. [Pg.96]

Appropriate animal models of human heart disease are an attractive alternative for proteomic investigations as human diseased tissue samples can often be compromised by factors such as the disease stage, tissue heterogeneity, genetic variability, and the patient s medical history/therapy. Avoiding any of the above complications when working with human samples can prove to be extremely difficult... [Pg.301]

PHP, a rare heterogeneous genetic disorder characterized by end-organ resistance to parathyroid hormone, is discussed further in Chapter 8. Heterozygous inactivating GNAS mutations lead to PHP type la (PHP-Ia) when maternally inherited, or pseudopseudohypoparathyroidism (PPHP), if paternally derived [48]. To date, only variants of the Ga- and Gp-subunits of the G protein have been implicated in human disease—no Gy-subunit disruptions have been identified. [Pg.125]

Biofilms can form on just about any imaginable surface metals, plastics, natural materials (such as rocks), medical implants, kitchen coimters, contact lenses, the walls of a hot tub or swimming pool, hmnan and animal tissue, etc. Indeed, wherever the combination of moisture, nutrients, and a surface exists, biofilms will likely be foimd as well. Biofilms are characterized by structural heterogeneity, genetic diversity, complex community interactions, and an extracellular matrix of pol)uneric substances. Biofilms are an important link in the energy budget of many natural commimities. Both types of cells produce a pol)uneric extracellular slime layer which encloses the cells. This complex aggregate of cells and polysaccharide is the biofilm community. [Pg.405]

The spectrum of these monoterpenes is very wide. There are representatives of each type of the basic monoterpene skeletons except the carane group. Even if the main component itself is usually not enough for evaluation of the characteristics of the oil, tansy is a good example to illustrate the fact that the main compounds of different chemotypes may not necessarily belong to the same skeleton. It also means that they are not always products of closely related biosynthetic pathways, which might re ect a really heterogeneous genetic structure. [Pg.94]

Hypogonadotropic hypogonadism is a genetically heterogeneous disorder characterized by infertility and... [Pg.608]

P-Lactamases are enzymes that hydrolyze the P-lactam ring of P-lactamantibiotics (penicillins, cephalosporins, monobactams and carbapenems). They are the most common cause of P-lactam resistance. Most enzymes use a serine residue in the active site that attacks the P-lactam-amid carbonyl group. The covalently formed acylester is then hydrolyzed to reactivate the P-lacta-mase and liberates the inactivated antibiotic. Metallo P-lactamases use Zn(II) bound water for hydrolysis of the P-lactam bond. P-Lactamases constitute a heterogeneous group of enzymes with differences in molecular structures, in substrate preferences and in the genetic localizations of the encoding gene (Table 1). [Pg.771]

Dietary consumption of polyphenols is associated with a lower risk of degenerative diseases. In particular, protection of serum lipids from oxidation, which is a major step in the development of arteriosclerosis, has been demonstrated. More recently, new avenues have been explored in the capacity of polyphenols to interact with the expression of the human genetic potential. The understanding of the interaction between this heterogeneous class of compounds and cellular responses, due either to their ability to interplay in the cellular antioxidant network or directly to affect gene expression, has increased. [Pg.13]


See other pages where Genetic heterogeneity is mentioned: [Pg.22]    [Pg.82]    [Pg.210]    [Pg.118]    [Pg.106]    [Pg.822]    [Pg.317]    [Pg.201]    [Pg.383]    [Pg.522]    [Pg.524]    [Pg.345]    [Pg.23]    [Pg.1211]    [Pg.22]    [Pg.82]    [Pg.210]    [Pg.118]    [Pg.106]    [Pg.822]    [Pg.317]    [Pg.201]    [Pg.383]    [Pg.522]    [Pg.524]    [Pg.345]    [Pg.23]    [Pg.1211]    [Pg.476]    [Pg.441]    [Pg.342]    [Pg.374]    [Pg.127]    [Pg.423]    [Pg.446]    [Pg.611]    [Pg.1070]    [Pg.30]    [Pg.294]    [Pg.306]    [Pg.438]    [Pg.538]    [Pg.565]    [Pg.569]    [Pg.8]    [Pg.165]    [Pg.166]    [Pg.281]    [Pg.107]    [Pg.264]    [Pg.267]    [Pg.248]    [Pg.358]    [Pg.170]    [Pg.34]   
See also in sourсe #XX -- [ Pg.50 ]




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