Renal gluconeogenesis

Kessar, P. and Sa erson, E.D. (1980). Evidence that catecholamines stimulate renal gluconeogenesis through a-type of adrenoceptor. Biochem. J. 190, 119-123. 

Goldstein, R.S., Contardi, L.R., Pasino, D.A. and Hook, J.B. (1987). Mechanisms mediating cephaloridine inhibition of renal gluconeogenesis. Toxicol. Appl. Pharmacol. 87(2) 297-305. 

Metformin Obscure Reduced hepatic and renal gluconeogenesis Decreased endogenous glucose production Type 2 diabetes Oral maximal plasma concentration in 2-3 h Toxicity Gastrointestinal symptoms, lactic acidosis (rare) cannot use if impaired renal/hepatic function congestive heart failure (CHF), hypoxic/acidotic states, alcoholism... 

Gerich, J.E., Meyer, C., Woerle, H.J., Stumvoli, M. (2001) Renal gluconeogenesis its importance in human glucose homeostasis. Diabetes Care 24, 382-391. 

Goldstein RS, Contardi LR, Pasino DA,HookJB. Mechanisms mediating cephaloridine inhibition of renal gluconeogenesis.Toxi-colAppIPharmacol 1987 87 297-305. 

Kll. Krebs, H. A., Renal gluconeogenesis. Advan. Enzyme Regul. 1, 385-400 (1963). 

Gerich JE, Meyer C, Woerle HJ, Stumvoll M. Renal gluconeogenesis. Its importance in human glucose homeostasis. Diabetes Care 2001 24 382-391. 

Thyroid hormones regulate the turnover of carbohydrates, lipids, and proteins. They promote glucose absorption, hepatic and renal gluconeogenesis, hepatic glycogenolysis, and glucose utilization in muscle and adipose tissue (18). They increase de novo cholesterol synthesis but increase low-density lipoprotein degradation and cholesterol disposal even more, leading to a net decrease in total and in low-density lipoprotein cholesterol plasma levels (19). Thyroid hormones are anabolic when present at normal concentrations they then stimulate the expression of many key enzymes of metabolism. ... 

This close relationship observed between the increment in WB Ra of glucose and increased net liver release of glucose (Galindo, 2010) suggests very limited contribution of increased renal gluconeogenesis to support the increment of glucose WB Ra that has been observed with increased protein supply. 

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