Chlorhexidine acetate

Examples of preservatives are phenylmercuric nitrate or acetate (0.002% w/v), chlorhexidine acetate (0.01 % w/v), thiomersal (0.01 % w/v) and benzalkorrium chloride (0.01 % w/v). Chlorocresol is too toxic to the comeal epithehum, but 8-hydroxyquinoline and thiomersal may be used in specific instances. The principal considerahon in relation to antimicrobial properties is the activity of the bactericide against Pseudomonas aeruginosa, a major source of serious nosocomial eye infections. Although benzal-konium chloride is probably the most active of the recommended preservatives, it cannot always be used because of its incompatibility with many compounds commonly used to treat eye diseases, nor should it be used to preserve eye-drops containing anaesthetics. Since benzalkonium chloride reacts with natural mbber, silicone or butyl rabber teats should be substituted. Since silicone mbber is permeable to water vapour, products should not be stored for more than 3 months after manufacture. As with all mbber components, the mbber teat should be pre-equilibrated with the preservative prior to... 

Non-aqueous titration with acetous perchloric acid is used in the pharmacopoeial assays of adrenaline, metronidazole, codeine, chlorhexidine acetate, chlorpromazine.HCl, amitriptyline.HCl, propranolol.HCl, lignocaine.HCl and quaternary amine salts such as neostigmine bromide and pancuronium bromide. 

An acute anaphylactic reaction occurred in a 19-year-old man after cleaning of burns on the left arm (44). A scratch test with chlorhexidine acetate 0.05% was positive. 

Evans RJ. Acute anaphylaxis due to topical chlorhexidine acetate. BMJ 1992 304(6828) 686. 

Richards RME, McBride RJ. Enhancement of benzalkonium chloride and chlorhexidine acetate activity against Pseudomonas aeruginosa by aromatic alcohols. ] Pharm Sci 1973 62 2035-2037. 

In aqueous solution, chlorhexidine salts may undergo hydrolysis to form 4-chloroaniline. Following autoclaving of a 0.02% w/v chlorhexidine gluconate solution at pH 9 for 30 minutes at 120°C, it was found that 1.56% w/w of the original chlorhexidine content had been converted into 4-chloroaniline for solutions at pH 6.3 and 4.7 the 4-chloroaniline content was 0.27% w/w and 0.13% w/w, respectively, of the original gluconate content. In buffered 0.05% w/v chlorhexidine acetate solutions, maximum stability occurs at pH 5.6. 

Chlorhexidine acetate chlorhexidine gluconate chlorhexidine hydrochloride. 

Moisture content chlorhexidine acetate is hygroscopic, absorbing significant amounts of moisture at relative humidities up to about 80% and temperatures up to 37°C. 

Sodium stearyl fumarate is reported to be incompatible with chlorhexidine acetate. ... 

Carbon dioxide-free water Cationic emulsifying wax Ceratonia extract Cetylpyridinium bromide Chlorhexidine acetate Chlorhexidine gluconate Chlorhexidine hydrochloride Chlorodifluoromethane Chlorophenoxyethanol Com syrup solids m-Cresol o-Cresol p-Cresol... 

Some ingredients of eye medications may increase the permeability of the cornea. Surface-active agents are knovm to interact with membranes to increase the permeability benzalkonium chloride has surfactant properties and may well have some effect on comeal permeability, although its primary purpose is as a bacteriostat and bactericide. Chlorhexidine acetate and cetrimide, both of which are surface-active, are also used. 

It can be used prior to surgery and in obstetrics, but is used mainly (as chlorhexidine acetate, chlorhexidine gluconate or chlorhexidine hydrochloride) either as a mouthwash for oral hygiene or as a dressing for minor skin wounds and Infections. It can also be used for instillation in the bladder to relieve minor infections, chlorhexidine acetate chlorhexidine, chlorhexidine gluconate chlorhexidine. 

Chlorhexidine diacetate CAS 56-95-1 EINECS/ELINCS 200-302-4 Synonyms 1,6-Bis (5-(p-chlorophenyl) biguanidino) hexane diacetate Chlorhexidine acetate 1,6-Di (4 -chlorophenyldiguanidino) hexane diacetate 1,1 -Hexamethylene bis [5-(4-chlorophenyl) biguanide] diacetate 1,1 -Hexamethylenebis (5-(p-chlorophenyl) biguanide) diacetate... 

PU/nanoclay nanocomposite nanofibrous webs prepared by electrospinning were reported. Chlorhexidine acetate was loaded in the prepared clay and was then incorporated into PU nanofibers. The nanofibers were evaluated for moisture vapor transmission, porosity, contact angle, and antibacterial activity, important for topical drug delivery application [94]. Verreck et al. described the preparation of nanofibers by electrospinning of itraconazole and ketanserin in a non-biodegradable matrix. It improved the transdermal delivery of these poorly soluble drugs. It was shown that these two drugs exist in the amorphous state in the PU nanoflbers [95]. 

The minimum inhibition concentrations listed in Table 142 show that the Chlorhexidine digluconate formulation disposes of a broad efficacy spectrum. It may be utilized as a preservative in cosmetics, as an active ingredient in handwashes and scrubs, for dental and veterinary applications. - Percentage of use in US formulations chlorhexidine digluconate 0.09% chlorhexidine acetate 0.01% chlorhexidine dihydrochloride 0.02%. 

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