Chlorhexidine hydrochloride

Conessine Hydrobromide 578.4 Chlorhexidine Hydrochloride 685.0 Prednisolone Steaglate... 

Inositol Nicotinate Terbutaline Sulphate Chlorhexidine Hydrochloride Naphazoline Hydrochloride Sulphadiazine Sulphasalazine Mepivacaine Hydrochloride Digitoxin... 

Chlorhexidine gluconate solution Chlorhexidine hydrochloride JP Chlorhexidine gluconate solution... 

Chlorhexidine and its salts are stable at normal storage temperatures when in the powdered form. However, chlorhexidine hydrochloride is hygroscopic, absorbing significant amounts of moisture at temperatures up to 37°C and relative humidities up to 80%. 

Heating to 150°C causes decomposition of chlorhexidine and its salts, yielding trace amounts of 4-chloroaniline. However, chlorhexidine hydrochloride is more thermostable than the acetate and can be heated at 115°C for 1 hour without appreciable formation of 4-chloroaniline. 

Chlorhexidine acetate chlorhexidine gluconate chlorhexidine hydrochloride. 

Comments chlorhexidine hydrochloride may be sterilized by dry heat. See Sections 11 and 12. 

Carbon dioxide-free water Cationic emulsifying wax Ceratonia extract Cetylpyridinium bromide Chlorhexidine acetate Chlorhexidine gluconate Chlorhexidine hydrochloride Chlorodifluoromethane Chlorophenoxyethanol Com syrup solids m-Cresol o-Cresol p-Cresol... 

It can be used prior to surgery and in obstetrics, but is used mainly (as chlorhexidine acetate, chlorhexidine gluconate or chlorhexidine hydrochloride) either as a mouthwash for oral hygiene or as a dressing for minor skin wounds and Infections. It can also be used for instillation in the bladder to relieve minor infections, chlorhexidine acetate chlorhexidine, chlorhexidine gluconate chlorhexidine. 

Chlorhexidine dihydrochloride CAS 3697-42-5 EINECS/ELINCS 223-026-6 Synonyms N,N -Bis (4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide, dihydrochloride Chlorhexidine HCI Chlorhexidine hydrochloride 2,4,11,13-Tetraazatetradecanediimidamide, N,N -bis (4-chlorophenyl)-3,12-diimino-, dihydrochloride Definition Salt of chlorhexidine and hydrochloric acid... 

Chlorhexidine base is not readily soluble in water therefore the freely soluble salts, acetate, gluconate and hydrochloride, are used in formulation. Chlorhexidine exhibits the greatest antibacterial activity at pH 7-8 where it exists exclusively as a di-cation. The cationic nature of the compound results in activity being reduced by anionic compounds including soap and many anions due to the formation of insoluble salts. Anions to be wary of include bicarbonate, borate, carbonate, chloride, citrate and phosphate with due attention being paid to the presence of hard water. Deionized or distilled water should preferably be used for dilution purposes. Reduction in activity will also occur in the presence of blood, pus and other organic matter. 

Chlorhexidine is available in the form of acetate, gluconate, or hydrochloride. Chlorhexidine salts are incompatible with soaps and other anionic materials. Fabrics in contact with chlorhexidine solution may develop brown stains if bleached with hypochloride. 

Chlorhexidini digluconatis solutio Chlorhexidini dihydrochloridum Chlorhexidine gluconate solution Chlorhexidine is usually encountered as the acetate, gluconate, or hydrochloride salt, and a number of pharmacopeias contain monographs for such materials. See Sections 9 and 17. 

Chlorhexidine may be prepared either by condensation of polymethylene bisdicyandiamide with 4-chloroaniline hydrochloride or by condensation of 4-chlorophenyl dicyandiamine with hexamethylenediamine dihydrochloride. Chlorhexidine may also be synthesized from a series of biguanides. ... 

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