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Characterization techniques thermodynamic stability

With the exception of thermodynamically stabilized [64] or sterically protected [65] carbenes, these species and their hetero-analogs, nitrenes, are very reactive and therefore special conditions are required for their direct observation. Fast spectroscopic techniques capable of characterizing species with lifetimes of a few picoseconds have been used [1-3]. More recently, time-resolved IR (TRIR) experiments have been used to characterize species with lifetimes of microseconds and even nanoseconds [4-6]. [Pg.140]

When rotaxanes and catenanes contain redox-active units, electrochemical techniques are a very powerful means of characterization. They provide a fingerprint of these systems giving fundamental information on (i) the spatial organization of the redox sites within the molecular and the supramolecular structure, (ii) the entity of the interactions between such sites, and (iii) the kinetic and thermodynamic stabilities of the reduced/oxidized and charge-separated species. [Pg.379]

The electrochemical characterization of multi-electron electrochemical reactions involves the determination of the formal potentials of the different steps, as these indicate the thermodynamic stability of the different oxidation states. For this purpose, subtractive multipulse techniques are very valuable since they combine the advantages of differential pulse techniques and scanning voltammetric ones [6, 19, 45-52]. All these techniques lead to peak-shaped voltammograms, even under steady-state conditions. [Pg.507]

The exploration of the crystal form space (polymorph screening) of a substance is the search of the polymorphs and solvates with a twofold purpose (i) identification of the relative thermodynamic stability of the various forms including the existence of enantiotropic crystalline forms (that interconvert as a function of the temperature) or of monotropic forms (that do not interconvert) and of amorphous and solvate forms and (ii) physical characterization of the crystal forms with as many analytical techniques as possible. The relationships between the various phases and commonly used industrial and research laboratory processes are illustrated schematically in Fig. 3.3.3. [Pg.296]

A wide spectrum of analytical techniques may be used to characterize polymorphs and pseudopolymorphs in terms of their structure, spectral energies, thermodynamic stabilities, kinetics of transformation and solubility behaviour. [Pg.180]

Further information is obtained if the amount of liquid adsorbed on the surface of the particle is also determined, permitting the combination of the data on heat of immersion with those on the amount of adsorbed liquid. Thus, molar adsorption enthalpies can be given for the characterization of the stabilizing adsorption layer [12-16]. A further benefit of adsorption excess isotherms is that it is possible to calculate from them the free enthalpy of adsorption as a function of composition. When these data are combined with the results of calorimetric measurements, the entropy change associated with adsorption can also be calculated on the basis of the second law of thermodynamics. Thus, the combination of these two techniques makes possible the calculation of the thermodynamic potential functions describing adsorption [14,17-19]. [Pg.358]

Despite the utility of the additivity rule, without supporting data occasionally it can be difficult to narrow down possible solution structures to one possibility based on EPR data alone. EPR is frequently paired with other techniques, most often po-tentiometry [41,42,44-48], to detect the number of species and to use the additivity rule to give insights into the first coordination sphere donor atoms of the moieties in solution. This information can then be used in the fitting of potentiometric titration curves, which reports on the absolute and relative thermodynamic stabilities of species in solution. EPR spectroscopy is also used as a complementary technique to V NMR [49-51], allowing for characterization of both V(IV) and V(V) complexes in solution. Other techniques include UV-Vis spectroscopy [41,44,46], circular dichroism [48] and neutron activation analysis [52-56]. [Pg.514]

We also tested the applicability of the Ag -labeling technique for the characterization of assemblies with much lower thermodynamic stability such as single rosettes [22], Assemblies possessing aromatic n-donor systems in the melamine units (Figure 5) that provide a sandwich-type binding site for Ag, formed stable Ag -adducts that could be conveniently detected with MALDI-TOF MS. Even in these cases formation of fragmented assemblies was not observed. [Pg.186]

An increasing number of chemists use electrochemistry as a characterization technique in a fashion analogous to their use of infrared, UV-visible, NMR, and ESR spectroscopy. Some of the chemical questions that are amenable to treatment by electrochemistry include (1) the standard potentials (E°) of the compound s oxidation-reduction reactions, (2) evaluation of the solution thermodynamics of the compound, (3) determination of the electron stoichiometry of the compound s oxidation-reduction reactions, (4) preparation and study of unstable intermediates, (5) evaluation of the valence of the metal in new compounds, (6) determination of the formulas and stability constants of metal complexes, (7) evaluation of M-X, H-X, and O-Y covalent-bond-formation energies (-AGbf), and (8) studies of the effects of solvent, supporting electrolyte, and solution acidity upon oxidation-reduction reactions. [Pg.102]

A beautiful and elegant example of the intricacies of surface science is the formation of transparent, thermodynamically stable microemulsions. Discovered about 50 years ago by Winsor [76] and characterized by Schulman [77, 78], microemulsions display a variety of useful and interesting properties that have generated much interest in the past decade. Early formulations, still under study today, involve the use of a long-chain alcohol as a cosurfactant to stabilize oil droplets 10-50 nm in diameter. Although transparent to the naked eye, microemulsions are readily characterized by a variety of scattering, microscopic, and spectroscopic techniques, described below. [Pg.516]

This chapter will explore the relationship of thermodynamic and kinetic data as it pertains to characterizing the stability of various protein systems in the liquid state. Finally, from the wealth of information generated over the past few decades, it should be possible to assess the practical use of microcalorimetry for predicting stability. This technique used in combination with several other bio-analytical methods can serve as a powerful tool in the measurement of thermodynamic and kinetic phenomena.3-9 Attention will be given to limitations of the technique rendered from different applications as well as to areas where it is advantageous. Ultimately, the practical utility of this technique will rest with those familiar with the art. [Pg.328]

Here, rheology is used to characterize the gel state, whose stability, as measured thermodynamically or kinetically, can be described by temperature-concentration phase diagrams or simply time. The structural features of gelator aggregates at nanoscopic scales are described via data from the complementary techniques of electron microscopy and scattering techniques. Finally, the optical properties, including absorption and luminescence, are detailed. [Pg.286]

Besides quantitative determinations of endogenous PGs, HPLC techniques have been used for some special features in clinical, chemical, or pharmaceutical research, including investigations of stability, metabo-lization and enantiomeric purity, thermodynamic characterizations of chemical equilibria, validating im-... [Pg.1276]

The characterization of liposomes is an important task and many analytical techniques have been employed, Thermodynamic, mechanical, chemical, microscopic, spectroscopic, and chromatographic techniques have being used worldwide in order to test the physical and chemical, characteristics of liposomal formulations such as lamellerity, encapsulation efficiency and their stability overtime. [Pg.193]

Calorimetry is one of the few biophysical techniques that permits a direct characterization of the energetics of hyperthermophile proteins at physiologically relevanttemperatures. No other method directly measures enthalpy changes, and as such it should be viewed as an essential tool for thermodynamic studies. However, calorimetry is not selective. It sees everything, and thoefore interpretation in the presence of linked reactions can be difficult or deceptive. Thermodynamic descriptions often resemble a Russian Matryoshka doll in that we often think we understand a system, only to discover that there is another unforeseen little doU hidden within. A global analysis of DSC, ITC, and spectroscopic data can often resolve these difficulties and make it more likely to achieve an accurate representation of the stability and function of hyperthermophile proteins. [Pg.422]


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