Cetomacrogol

Reaction with acetic anhydride is used in pharmacopoeial assays of benzyl alcohol and dienestrol and determination of hydroxyl values of castor oil, cetosteryl alcohol and cetomacrogol. 

Non-ionic surfactants are used in formulations to solubilise drugs with poor water solubility these compounds consist in their simplest form of an alkyl group attached to a polyethylene glycol chain. Non-ionic surfactants are usually mixtures, e.g. Cetomacrogol 1000, which has the general formula ... 

This product is an aqueous solution of water-soluble vitamins with oily vitamin A palmitate and cholecalceferol solubilized in water using the surfactant system of Tween 80 and Cetomacrogol. This syrup is a solubilized oil surfactant system and is liable to heat and rate of mixing. The temperature of solution must not exceed 30°C at the time of final mixing. The final mixing must be in continuous manner without any interruption. For the preparation of oily phase, the container must be dry. 

Cetomacrogol 1000, cetyl alcohol, stearyl alcohol Propylene glycol stearate, polysorbate 40... 

Cetomacrogol 1000 BP, cetostearyl alcohol Cetyl alcohol, stearyl alcohol, cetyl esters wax, polyoxyl 40 stearate, polyoxyl 8 stearate... 

FIGURE 2.3 Hypoglycemic effects of insulin administered rectally to rats in PEG base containing POE monostearate (Myrj 45, open triangles), POE (45) stearyl ether (Texofor A6, close triangles), POE (20) sorbitol monolaurate (Polysorbate 20, open circles), and POE 20-24 monocetyl ether (cetomacrogol 1000, closed circles). (From Touitou, E., J. Control. Release, 21, 139, 1992. With permission from Elsevier.)... 

Co-administration of insulin with the nonionic surface active agent, Cetomacrogol 1,000, in a PEG 400 base has been shown to lower blood glucose when administered vaginally to female rats with streptozocin-... 

Table 8 Micellar partition coefficients of metbylpbenols by cetomacrogol ...

Oil-in-water creams, for topical use, generally contain mixed emulsifiers/surfactants one of which is a water soluble surfactant with a high HLB, the other being an amphiphile, usually a long chain fatty alcohol (e.g., of chain length C14 to Cig) or acid (e.g., palmitic or stearic). The water soluble surfactant may be anionic (e.g., sodium lauryl sulphate), cationic (e.g., cetri-mide), or non-ionic (e.g., cetomacrogol. Tweens). 

Eccleston GM. Structure and rheology of cetomacrogol creams The influence of alcohol chain length and homologue composition. Pharm Pharmacol 1997 29 157-162. 

At a concentration of 0.1 %, chlorocresol may be completely inactivated in the presence of nonionic surfactants, such as polysorbate 80. However, other studies have suggested an enhancement of antimicrobial properties in the presence of surfactants. Bactericidal activity is also reduced, due to binding, by cetomacrogol, methylcellulose, pectin, or cellulose derivatives. In emulsified or solubilized systems, chlorocresol readily partitions into the oil phase, particularly into vegetable oils and higher concentrations will be required for efficient preservation. ... 

Kazmi SJA, Mitchell AG. Preservation of solubilized and emulsified systems II theoretical development of capacity and its role in antimicrobial activity of chlorocresol in cetomacrogol-stabilized systems. J Pharm Sci 1978 67 1266-1271. 

Kazmi SJA, Mitchell AG. Interaction of preservatives with cetomacrogol. / Pharm Pharmacol 1971 23 482-489. 

Cetomacrogol 1 000 Polyoxyl 6 cetostearyl ether Polyoxyl 20 cetostearyl ether Polyoxyl 25 cetostearyl ether Polyoxyl 2 cetyl ether Polyoxyl 1 0 cetyl ether Polyoxyl 20 cetyl ether Polyoxyl 4 lauryl ether Polyoxyl 9 lauryl ether Polyoxyl 23 lauryl ether Polyoxyl 2 oleyl ether Polyoxyl 1 0 oleyl ether Polyoxyl 20 oleyl ether Polyoxyl 2 stearyl ether Polyoxyl 10 stearyl ether Polyoxyl 21 stearyl ether Polyoxyl 100 stearyl ether... 

Ammar HO, Khali RM. Solubilization of certain analgesics by Cetomacrogol 1000. Egypt ] Pharm Sci 1996 37 261—271. 

Nonionic emulsifying wax is also used in nonaqueous ointment bases, such as cetomacrogol emulsifying ointment BP, and in barrier creams. 

Barry, B.W. and Saunders, G.M., Rheology of systems containing cetomacrogol 1000-cetostearyl alcohol. 1. Self-bodying action, J. Colloid Interface Sci. 38(3), 616-625,1972. 

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