Cetomacrogol sulphate

Figure 8.14 Change of zeta-potential with concentration of surfactant for chlorobenzene globules in aqueous solutions of (I) cetomacrogol sulphate and (II) cetomacrogol. From Attwood and Florence [76] with permission.

Oil-in-water creams, for topical use, generally contain mixed emulsifiers/surfactants one of which is a water soluble surfactant with a high HLB, the other being an amphiphile, usually a long chain fatty alcohol (e.g., of chain length C14 to Cig) or acid (e.g., palmitic or stearic). The water soluble surfactant may be anionic (e.g., sodium lauryl sulphate), cationic (e.g., cetri-mide), or non-ionic (e.g., cetomacrogol. Tweens). 

Recently, insulin absorption via the jejunum has been effected by administration of insulin-cetomacrogol solutions to diabetic rats [87]. Results presented in Table 7.5 are most likely to be due to a membrane effect rather than a surfactant-protecting effect on insulin degradation, as insulin administered h after cetomacrogol elicited a hypoglycaemic effect (see Section 7.4.2 below on rectal absorption). Sodium lauryl sulphate (0.75%) and sodium taurocholate (3.2 %) have been reported to cause an increase in the percentage of insulin absorbed from the ligated rat jejunal loop from 0.4% to 3.2% and 3.4%,... 

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