Blood glucose lowering

The blood glucose-lowering effect of oral antidiabetics is increased... 

The following are examples of substances that may increase the blood glucose-lowering effect and susceptibility to hypoglycemia oral antidiabetic products, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAO inhibitors, pentoxifylline, propoxyphene, salicylates, and sulfonamide antibiotics. 

Combination therapy When used in combination with other oral blood glucose-lowering agents, add the second agent at the lowest recommended dose and observe patients carefully. 

D) Thiazolidinediones take many days to weeks to begin exerting a blood glucose-lowering effect in diabetics. 

It is an oral blood glucose lowering drug of sulfonylurea class. 

Clarithromycin, an inhibitor of CYP3A4, increases the plasma concentrations and the effect of repaglinide this can enhance the blood glucose lowering effect and increase the risk of hypoglycemia (59). 

Blood Glucose Lowering Activity in Conscious Rabbits... 

Groups of 4-5 mixed breed rabbits of either sex weighing 3.0-4.5 kg are used. For insulin evaluation, food is withheld overnight. For evaluation of sulfonylureas and other blood glucose lowering agents the animals... 

Oral blood glucose lowering substances are applied by gavage in 1 ml/kg of 0.4% starch suspension or intravenously in solution. Several doses are given to different groups. One control group receives the vehicle only. By puncture of the ear veins, blood is withdrawn immediately before and 1,2,3,4, 5,24,48, and 72 hours after treatment. For time-response curves values are also measured after 8,12,16, and 20 hours. Blood glucose is determined in 10 pi blood samples. 

For special purposes the effect of blood glucose lowering agents is studied in glucose loaded animals. Rabbits of either sex weighing 3.0-4.5 kg are treated either once (0.5 h after test compound) or twice (0.5 and 2.5 hours after test compound) orally with 2 g glucose/kg body weight in 50 % solution. 

I. Blood Glucose-Lowering Agents A. Dipeptidyl Peptidase-IV Inhibitors... 

Utility Blood Glucose-lowering Agents for Treating Type II Diabetes... 

Guar gum, which is covered in a separate monograph, comes from the endosperm of the seeds of Cyamopsis tetragonoloba (cluster bean). It has a small hypolipidemic effect (20) and a small blood glucose-lowering effect (21). 

Thiazide drugs can oppose the blood glucose-lowering effects of oral hypoglycemic drugs and insulin (48) (although this effect is rarely serious). 

Because diabetes is a heterogeneous disease, each patient must be treated individually. More studies, however, are necessary to determine which of several available sulphonylureas is most appropriate in clinical treatment. The evidence of the relative efficacy of sulphonylureas, however, is still inconclusive. The blood glucose-lowering effect has always been primarily attributed to their insulinotropic action. In subjects not previously exposed to sulphonylureas, close association between the appearance of the drug in the plasma after a single dose and the release of insulin has been amply demonstrated. Sulphonylureas, however, also seem to exert potent extra-pancreatic effects. This may explain why, in two recent reports, these agents were found to also be beneficial in the management of insulin-dependent diabetes. 

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