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Polyethylene glycol chain

PEG has been converted into a solid support by grafting functionalized polyethylene glycol chains onto polystyrene to form constructs such as TentaGel ... [Pg.181]

Figure 2.8 shows part of a polyethylene glycol chain and illustrates the type of problem encountered with real chains. First, there are fixed bond angles (in this case the tetrahedral angle), and second, there is the physical volume occupied by each atom so that the walk cannot for example cross itself. Both of these constraints mean that the random... [Pg.30]

Collnot E-M, Baldes C, Wempe MF, Hyatt J, Navarro L, Edgar KJ, Schaefer UF, Lehr C-M (2006) Influence of vitamin E TPGS polyethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers. J Control Release 111 35—40... [Pg.451]

Non-ionic surfactants are used in formulations to solubilise drugs with poor water solubility these compounds consist in their simplest form of an alkyl group attached to a polyethylene glycol chain. Non-ionic surfactants are usually mixtures, e.g. Cetomacrogol 1000, which has the general formula ... [Pg.268]

Fig. 11. In a system of water and hydrocarbon a nonionic emulsifier with a polyethylene glycol) chain as the polar part dissolves in the aqueous phase at low temperatures (a) and in the oil phase at high temperatures (c). At an intermediate temperature (b) three isotropic liquid phases maybe found. Fig. 11. In a system of water and hydrocarbon a nonionic emulsifier with a polyethylene glycol) chain as the polar part dissolves in the aqueous phase at low temperatures (a) and in the oil phase at high temperatures (c). At an intermediate temperature (b) three isotropic liquid phases maybe found.
Furthermore, they prepared supramolecular antenna systems using polyro-taxanes with naphthalene-modified a-CD as the ring unit and anthracene units at the ends of the threading polyethylene glycol) chain (108) [96], In this case, both energy migration between naphthalene units and energy transfer from naphthalene units to anthracene units were observed. [Pg.493]

The complex multicomponent system, called CALAA-01, has been developed by Davis for Calando Pharmaceuticals and is the first of many possible RONDEL therapeutics based on a biomimetic approach to drug delivery [24], The approach combines a linear cationic polymer that incorporates cyclodextrins, a therapeutic payload (siRNA strands that target a specific process), and adamantane molecules modified with biocompatible polyethylene glycol chains (PEGs) or complementary proteins that bind to the target cell types. [Pg.247]

Figure 27 Bivalent sLe ligands generated by Wong. The selectin epitopes were linked through the 3- and 6-positions of galactose (55) and via a polyethylene glycol chain (56). Figure 27 Bivalent sLe ligands generated by Wong. The selectin epitopes were linked through the 3- and 6-positions of galactose (55) and via a polyethylene glycol chain (56).
Pegylation, defined as the chemical process by which polyethylene glycol chains are attached to protein and peptide drugs, have been successfully applied to produce peginterferon alfa-2a (PEGASYS) and peginterferon alfa-2b (PEG-Intron), both of which have been approved by the FDA for the treatment of chronic hepatitis C [203]. [Pg.400]

Figure 7.8 The first class of concave reagents were bimacrocyclic 2,6-disubstituted pyridines with amide bridgeheads building up the bimacrocycle. The bridges X and Y were polymethylene but also polyethylene glycol chains, the basicity of the pyridine could be tuned by respective substituents R in 4-position ... Figure 7.8 The first class of concave reagents were bimacrocyclic 2,6-disubstituted pyridines with amide bridgeheads building up the bimacrocycle. The bridges X and Y were polymethylene but also polyethylene glycol chains, the basicity of the pyridine could be tuned by respective substituents R in 4-position ...
Attachment of a polyethylene glycol chain to, for example, a protein, is called PEGylation. The covalent... [Pg.763]


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See also in sourсe #XX -- [ Pg.1286 ]




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