Cervical cancer cell growth

IL-6 induces terminal maturation of B cells, promotes the growth of hy-bridoma/myeloma cells and T cells, and acts upon haematopoietic progenitors in synergy with IL-1 and IL-3. It also induces the production of acute-phase proteins by liver cells. In addition to its production by neutrophils, IL-6 is also synthesised by monocytes, T and B cells, fibroblasts, cardiac myxoma cells, some bladder carcinomas, cervical cancer cells and glioblastomas. Stimulated neutrophils generate about ten times less IL-6 (on a per-cell basis) than do monocytes. 

Another group of closely related compounds is the phenstatins. Phenstatin (6a) and hydroxyphenstatin (6b) resulted from a SAR-study on combretastatin A-4 and exhibited potent inhibition of cancer cell growth [29]. Further modifications have been performed, resulting in highly potent agents, namely 243869 (6c) with in vitro toxicity of IC5o = 0.58 nM towards HeLa cervical carcinoma cells [40,41]. 

Hydroxymycotrienins A (102) and B (103), isolated from the culture broth of Bacillus sp. BMJ958-62F4, inhibited the growth of human cervical cancer cell lines of human papilloma virus (HPV) positive more strongly than that of HPV negative cell lines [164]. 

Pan et al. reported Tan-IIA exhibited strong growth inhibition against human cervical cancer cells (HeLa cells) in dose- and time-dependent manners with a 50% ceU growth inhibition with 2.5 pg/mL (8.49 pM). The authors executed a bioinformatics analysis of proteins to survey global protein changes induced by Tan-IIA... 

In vitro cytotoxic analysis of the main saffron compounds (crocins, crocetin, picrocrocin and safranal) using HeLa (human cervical epitheliod cancer) cells was carried out by Escribano et al [64]. It was found that in terms of LD50 values (dose inducing 50% cell growth inhibition on these cells) safranal has 0.8mM, crocin and picrocrocin 3mM respectively. Furthermore, Escribano et al [65] have also isolated from corms of Crocus sativus a glycoconjugate with cytotoxic activity as well. Experiments with carotenoids from Crocus sativus in HL60 cells were conducted by Tarantilis et al [66] where inhibition and induction of differentiation of these cells was studied. 

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