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Cerebral ischemia delayed

Oral nimodipine is recommended in subarachnoid hemorrhage to prevent delayed cerebral ischemia. Delayed cerebral ischemia occurs 4 to 14 days after the initial aneurysm rupture and is a common cause of neurologic deficits and death. A meta-analysis of 12 studies was conducted and concluded that oral nimodipine 60 mg every 4 hours for 21 days following aneurysmal SAH reduced the risk of a poor outcome and delayed cerebral ischemia.40... [Pg.172]

A critical factor in developing a therapeutic strategy against stroke is the time window available. In focal cerebral ischemia, delaying the... [Pg.49]

There is no proven treatment for intracerebral hemorrhage. Management is based on neurointensive care treatment and prevention of complications. Oral nimodipine is recommended in subarachnoid hemorrhage to prevent delayed cerebral ischemia. [Pg.161]

Oxidative neuronal damage also contributes to delayed neuronal death after global cerebral ischemia as demonstrated by studies in humans (Love et al. 1998, 1999). [Pg.6]

In the previous sections we have, by part, already reviewed delayed effects after cerebral ischemia, such as the risk of hemorrhagic complications that may occur as petechial bleedings or parenchymal hematoma. We have seen that the blood-brain barrier opens to various degrees with a substantial time... [Pg.63]

J, Oertel WH, Baethmann A (2002) Early versus delayed thrombolysis in embolic stroke effects on blood flow, DC potential and infarct morphology. In Krieglstein J, Klumpp S (eds) Pharmacology of cerebral ischemia. MedPharm Scientific Publishers, Stuttgart, pp 159-169... [Pg.67]

Li F, Han SS, Tatlisumak T, Liu KF, Garcia JH, Sotak CH, Fisher M (1999) Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats. Ann Neurol 46 333-342... [Pg.130]

Kim Y., Busto R., Dietrich W. D., Kraydieh S., and Ginsberg M. D. (1996) Delayed postischemic hyperthermia in awake rats worsens the histopathological outcome of transient focal cerebral ischemia. Stroke 27, 2274—2280 discussion 2281. [Pg.15]

The concept of neuroprotection relies on the fact that delayed neuronal injury occurs after ischemia, and each step along the ischemic cascade provides a target for therapeutic intervention. Thus, understanding the cellular and molecular mechanisms that underlie the development of neuronal and vascular injury is critical to optimize treatment. This chapter reviews experimental evidence from studies on focal cerebral ischemia and mild hypothermia, as well as the mechanisms involved in mild hypothermic neuroprotection. [Pg.40]

We recently carried out a study (40) to determine the effects of delaying induction of mild hypothermia after transient focal cerebral ischemia and to ascertain whether the neuroprotective effects of mild hypothermia induced during the ischemic period are sustained over... [Pg.50]

KaribeH.,ZarowG. J., GrahamS. H., and WeinsteinP.R. (1994) Mild intraischemic hypothermia reduces postischemic hyperperfusion, delayed postischemic hypoperfusion, blood-brain barrier disruption, brain edema, and neuronal damage volume after temporary focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 14, 620-627. [Pg.60]

Maier C. M., Sun G. H., Kunis D., Yenari M. A., and Steinberg G. K. (2001) Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia neurological outcome and infarct size. J. Neurosurg. 94, 90-96. [Pg.60]

Kollmar R., Schabitz W. R., Heiland S., et al. (2002) Neuroprotective effect of delayed moderate hypothermia after focal cerebral ischemia an MRI study. Stroke 33, 1899-1904. [Pg.62]

KEY STUDIES OF DELAYED HYPOTHERMIA IN RODENT GLOBAL CEREBRAL ISCHEMIA MODELS... [Pg.80]

Du C Hu R Csernansky C. A., Hsu C. Y and Choi D. W. (1996) Very delayed infarction after mild focal cerebral ischemia a role for apoptosis J. Cereb. Blood Flow Metab. 16, 195-201. [Pg.90]

Later on, focal symptoms are more likely to result from delayed cerebral ischemia. [Pg.351]

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See also in sourсe #XX -- [ Pg.423 ]



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