Experimental focal cerebral ischemia

Schabitz WR, Schade H, Heiland S, Kollmar R, Bardutzky J, Henninger N, Muller H, Carl U, Toyokuni S, Sommer C, Schwab S. Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by mr-imaging. Stroke 2004 35 1175-1179. 

Toung TJ, Hum PD, Traystman RJ, Bhardwaj A. Global brain water increases after experimental focal cerebral ischemia effect of hypertonic sahne. Crit Care Med 2002 30(3) 644-649. 

Meyer, F.B., Tally, P.W., Anderson, R.E., Sundt, T.M., Yaksh, T.L. and Sharbrough, F.W. (1987). Treatment of experimental focal cerebral ischemia with mannitol. Assessment by intracellular brain pH, cortical blood flow, and EEC. 

Mild Hypothermia in Experimental Focal Cerebral Ischemia... 

The middle cerebral artery occlusion model (MCAO) is commonly used in experimental focal cerebral ischemia. This technique causes hypothalamic injury resulting in hyperthermia, worsening outcome and possibly masking neuroprotective effects. Thus, careful temperature monitoring is needed in those preclinical studies. Recently, Gerriets et al. (10) introduced a new MCAO model that involves intraarterial embolizationusing macrospheres. Unlike the traditional MCAO suture model, this macrosphere model does not result in hyperthermia and yet provides reproducible infarcts. 

Resurgence of Hypothermia as a Treatment for Brain Injury. The Effects of Hypothermia and Hyperthermia in Global Cerebral Ischemia. Mild Hypothermia in Experimental Focal Cerebral Ischemia. Hypothermic Protection in Traumatic Brain Injury. Postischemic Hypothermia Provides Long-Term Neuroprotection in Rodents. Combination Therapy With Hypothermia and Pharmaceuticals for the T reatment of Acute Cerebral Ischemia. Intraoperative and Intensive Care Management of the Patient Undergoing Mild Hypothermia. Management of Traumatic Brain Injury With Moderate Hypothermia. Hypothermia Clinical Experience in Stroke Patients. Hypothermia Therapy Future Directions in Research and Clinical Practice. Index. 

Heo JH, Lucero J, Abumiya T, Koziol JA, Copeland BR, del Zoppo GJ (1999) Matrix metallopro-teinases increase very early during experimental focal cerebral ischemia. J Cereb Blood Flow Metab 19 624-633... 

H. P. Haring, E. L. Berg, N. Tsurushita, M. Tagaya, G. J. del Zoppo, E-Selectin Appears in Nonischemic Tissue During Experimental Focal Cerebral Ischemia, Stroke, 27 (1996) 1386-1392. 

Newcomb R, Pierce AR, Kano T, Meng W, Bosque-Hamilton P, Taylor L, Curthoys N, Lo EH (1998) Characterization of mitochondrial glutaminase and amino acids at prolonged times after experimental focal cerebral ischemia. Brain Res 5/5 103-111. 

Dardzinski BJ, Sotak CH, Fisher M, Hasegawa Y, Li L, Mine-matsu K (1993) Apparent diffusion coefficient mapping of experimental focal cerebral ischemia using diffusion-weighted echo-planar imaging. Magn Reson Med 30 318-325... 

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