Ischemia, cerebral neurogenesis

Jin, K., Sun, Y., Xie, L., Childs, J., , X.O., Greenberg, D.A. (2004). Post-ischemic administration of heparin-binding epidermal growth factor-like growth factor (HB-EGF) reduces infarct size and modifies neurogenesis after focal cerebral ischemia in the rat. J... 

Takasawa K, Kitagawa K, Yagita Y, Sasaki T, Tanaka S, Matsushita K, Ohstuki T, Miyata T, Okano H, Hori M, Matsumoto M (2002) Increased proliferation of neural progenitor cells but reduced survival of newborn cells in the contralateral hippocampus after focal cerebral ischemia in rats. J Cereb Blood Flow Metab 22 299-307 Tanaka R, Yamashiro K, Mochizuki H, Cho N, Onodera M, Mizuno Y, Urabe T (2004) Neurogenesis after transient global ischemia in the adult hippocampus visualized by improved retroviral vector. Stroke 35 1454-1459 Teramoto T, Qiu J, Plunder JC, Moskowitz MA (2003) EGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia. J Clin Invest 111 1125-1132... 

Shioda, N., Han, F., Morioka, M., and Fukunaga, K. (2008). Bis(l-oxy-2-pyridinethiolato)oxovana-dium(IV) enhances neurogenesis via phosphatidylinositol 3-kinase/Akt and extracellular signal regulated kinase activation in the hippocampal subgranular zone after mouse focal cerebral ischemia. Neuroscience 155, 876—887. 

Recent findings in rodents show that cerebral ischemia is another injury that stimulates neurogenesis in adult brain. Yagita etal. (2001) provide evidence that the proUferadng cells found after ischemia are neural progenitor cells (Yagita... 

Stem cell-based therapy for cerebral ischemia will be more complicated, because the extensive cell death and massive inflammatory response make these brains a more hostile environment for cell grafts. Various sources of cells have been tested for their ability to reconstruct the forebrain and improve function after transplantation in animal models of stroke (Lindvall and Kokaia, 2004). In most cases, only a few grafted cells could survive. Some recent exciting findings in rodents suggest that stroke can induce an increase in neurogenesis thus, a new therapeutic approach based on self-repair has been brought forth, as discussed in Sect. 13.11.1. 

Jin K, Minami M, Lan JQ, Mao XO, Batteur S, Simon RP, Greenberg DA (2001) Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc Natl Acad Sci USA 98 4710-4715. 

Hoehn BD, Palmer TD, Steinberg GK (2005) Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin. Stroke 36 2718-2724. 

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