Hyperbaric oxygenation

In the past, hyperbaric oxygenation as a medical procedure has received considerable attention. In this treatment the patient is given pure oxygen and may be placed in a pressurized chamber. In effect, the patient may thus receive >400 kPa (>4 atm) of pure oxygen. Beneficial results in cases of carbon monoxide poisoning, gangrene, severe bums, and other difficulties are often achieved as a result of this treatment. 

Burt JT, Kapp JP, Smith RR. Hyperbaric oxygen and cerebral infarction in the gerbil. Surg Neurol 1987 28 265-268. 

Lou M, Eschenfelder CC, Herdegen T, Brecht S, Deuschl G. Therapeutic window for use of hyperbaric oxygenation in focal transient ischemia in rats. Stroke 2004 35 578-583. 

Veltkamp R, Warner DS, Domoki F, Brinkhous AD, Toole JF, Busija DW. Hyperbaric oxygen decreases infarct size and behavioral deficit after transient focal cerebral ischemia in rats. Brain Res 2000 853 68-73. 

Sunami K, Takeda Y, Hashimoto M, Hirakawa M. Hyperbaric oxygen reduces infarct volume in rats by increasing oxygen supply to the ischemic periphery. Crit Care Med 2000 28 2831-2836. 

Schabitz WR, Schade H, Heiland S, Kollmar R, Bardutzky J, Henninger N, Muller H, Carl U, Toyokuni S, Sommer C, Schwab S. Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by mr-imaging. Stroke 2004 35 1175-1179. 

Roos JA, Jackson-Friedman C, Lyden P. Effects of hyperbaric oxygen on neurologic outcome for cerebral ischemia in rats. Acad Emerg Med 1998 5 18-24. 

Anderson DC, Bottini AG, Jagiella WM, Westphal B, Ford S, Rockswold GL, Loe-wenson RB. A pilot study of hyperbaric oxygen in the treatment of human stroke. Stroke 1991 22 1137-1142. 

Rusyniak DE, Kirk MA, May JD, Kao LW, Brizendine EJ, Welch JL, Cordell WH, Alonso RJ. Hyperbaric oxygen therapy in acute ischemic stroke results of the hyperbaric oxygen in acute ischemic stroke trial pilot study. Stroke 2003 34 571-574. 

Hyperbaric oxygen Hypertensive cerebrovascular injury Alcoholism... 

The nonpharmacologic treatment of diabetic foot ulcers may include off-loading, chemical or surgical debridement of necrotic tissue, wound dressings, hyperbaric oxygen, vascular or orthopedic surgery, and the use of human skin equivalents.30... 

There is no proven antidote for hydrogen sulfide poisoning. Treatment consists of supportive measures such as evaluating and supporting airway, breathing, and circulation (ATSDR 1994). Sodium nitrite may or may not be an effective antidote, but if proper precautions in administration are observed, intravenous administration of sodium nitrite may help some hydrogen sulfide poisoned persons (Hall 1996 Hall and Rumack 1997). Hyperbaric oxygen therapy is controversial, but it may be effective for patients not treated successfully by other measures (ATSDR 1994). 

Bitterman N, Talmi Y, Lerman A, et al. 1986. The effect of hyperbaric oxygen on acute experimental sulfide poisoning in the rat. Toxicol Appl Pharmacol 84 325-328. 

Smilkstein MJ, Bronstein AC, Pickett HM, et al. 1985. Hyperbaric oxygen therapy for severe hydrogen sulfide poisoning. J Emerg Med 3 27-30. 

Whitcraft DD III, Bailey TD, Hart GB. 1985. Hydrogen sulfide poisoning treated with hyperbaric oxygen. J Emerg Med 3 23-25. 

The effects of oxygen breathing on cognition in healthy people has only received limited attention. In the 1970s, Edwards and Hart examined the effects of hyperbaric oxygen administration on healthy elderly outpatients and found substantial... 

Edwards AE and Hart GM (1974). Hyperbaric oxygenation and the cognitive function of the aged. Journal of the American Geriatrics Society, 22, 376-379. 

McCormack, M., A.H.W. Nias, and E. Smith. 1990. Chronic anemia, hyperbaric oxygen and tumour radiosensitivity. Brit. Jour. Radiol. 63 752-759. 

Hyperactivity, sugar and, 23 478 Hyperbaric oxygenation, 77 764 Hyperbar vacuum filtration, 77 377 Hyperbilirubinemia, photochemical treatment of, 79 120... 

Goodhart GL. 1994. Patient treated with antidote kit and hyperbaric oxygen survives cyanide poisoning. South Med J 87(8) 814-816. 

Litovitz TL, Larkin RF, Myers RA. 1983. Cyanide poisoning treated with hyperbaric oxygen. Am J Emerg Med 1 94-101. 

Finally, hyperbaric oxygen treatments have also been used to increase the oxygen content of blood. In this way, a smaller amount of blood flowing to the brain might still provide an adequate supply of oxygen. 

Administration of hyperbaric oxygen following exposure to carbon tetrachloride improved survival from 31 to 96% in rats (Ellenhorn and Barceloux 1988). Hyperbaric oxygen has also been used in treating overdoses of carbon tetrachloride in humans and may correct regional tissue hypoxia and damage, as well as inhibit the P-450-dependent reductive dehalogentation of carbon tetrachloride to the metabolically active acute trichloromethyl radical in the liver. However, the effectiveness of this method has not been established in humans (Burkhart et al. 1991 Ellenhorn and Barceloux 1988). 

Burk RF, Reiter R, Lane JM. 1986. Hyperbaric oxygen protection against carbon tetrachloride hepatotoxicity in the rat. Association with altered metabolism. Gastroenterol 90 812-818. 

Burkhart KK, Hall AH, Gerace R, et al. 1991. Hyperbaric oxygen treatment for carbon tetrachloride poisoning. Drug Safety 6 332-338. 

We investigated homeostasis in patients with hver cirrhosis in the pre- and postoperative period, which has allowed us to reveal clinical pathological mechanisms of complications developed in the postoperative period and to study the effect of hyperbaric oxygenation to prevent these complications. 

Since 1995, to improve rehabilitation in our Centre, the hyperbaric oxygenation method has been used in the postoperative period in patients with liver cirrhosis. HBO was carried out in a single barocamera BLKS-3-01 in pure oxygen (purity 99.5%) at pressure of 1.6-2.0 kg-force cm . The duration of a session was 40-60 min, and 8-10 sessions were required for one course of treatment. All patients had a determined individual indication for HBO. 

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