Membranes, cellulose

Cellulosic Membranes The first commercial UF membranes were made from cellulose acetate (CA), with an acetyl content of about 37 percent. They are prized for their low level of interaction with proteins and are still used in other applications where long life is not critical. 

Regenerated cellulose membrane Regenerated cellulose membrane Regenerated cellulose membrane (silver-treated) Polyamide non-woven impregnated with regenerated cellulose... 

Water Permeation and Solute Separation through the Membrane. The measurements of water permeability of the 67 membranes prepared under different conditions were carried out by using an Amicon Diaflo Cell (effective membrane area, 13.9 cm2) under a pressure of 3 kg/cm2 at 25 °C. Some results are listed in Table 1067. It is apparent that much higher water absorption and permeability than the cellulosic membrane are characteristic of the 67 membranes prepared by both the casting polymerization and conventional casting. 

Ratio of apparent diffusion coefficient of 67 membrane to the cellulosic membrane. Visking dialyzer tubing. 

Cellulose was the first type of solid support introduced for SPPS [91 ] however, the scope of its use is limited by low loading capacity ( 0.1 mmol/g) and chemical stability. In spite of these drawbacks, microwave-assisted synthesis was successfully performed on cellulose membranes [92-94] and beads [95]. 

The membrane is critically important in osomometry. Selection of a membrane involves reconciliation of high permeability toward the solvent with virtual impermeability to the smallest polymer molecules present in the sample. Membranes of cellulose are most widely used. Commercially Regenerated cellulose film is a common source. The undried gel cellophane film is often preferred, but the dry film may be swollen in water (or in aqueous solutions of caustic or zinc chloride ) to satisfactory porosity. Useful cellulose membranes may also be prepared by denitration of nitrocellulose films/ and special advantages have been claimed for bacterial cellulose films. The water in the swollen membrane in any case may be replaced by a succession of miscible organic solvents ending with the one in which osmotic measurements are to be made. Membranes of varying porosity may be... 

The predominant RO membranes used in water applications include cellulose polymers, thin film oomposites (TFCs) consisting of aromatic polyamides, and crosslinked polyetherurea. Cellulosic membranes are formed by immersion casting of 30 to 40 percent polymer lacquers on a web immersed in water. These lacquers include cellulose acetate, triacetate, and acetate-butyrate. TFCs are formed by interfacial polymerization that involves coating a microporous membrane substrate with an aqueous prepolymer solution and immersing in a water-immiscible solvent containing a reactant [Petersen, J. Memhr. Sol., 83, 81 (1993)]. The Dow FilmTec FT-30 membrane developed by Cadotte uses 1-3 diaminobenzene prepolymer crosslinked with 1-3 and 1-4 benzenedicarboxylic acid chlorides. These membranes have NaCl retention and water permeability claims. 

Cellulose membranes can generally tolerate a pH of 3 to 6 and 0.3 to 1.0 ppm of chlorine while TFC membranes can generally tolerate a pH of 3 to 11 and < 0.05 ppm of chlorine. Membrane tolerance is also described as the permittee cumulative ppm-hours of membrane exposure to chlorine. TFC membranes can range from 1000 to 12,000 ppm h. Always check specific filter specifications. RO membranes... 

Scale prevention methods include operating at low conversion and chemical pretreatment. Acid injection to convert COs to CO2 is commonly used, but cellulosic membranes require operation at pH 4 to 7 to prevent hydrolysis. Sulfuric acid is commonly used at a dosing of 0.24 mg/L while hydrochloric acid is to be avoided to minimize corrosion. Acid addition will precipitate aluminum hydroxide. Water softening upstream of the RO By using lime and sodium zeolites will precipitate calcium and magnesium hydroxides and entrap some silica. Antisealant compounds such as sodium hexametaphosphate, EDTA, and polymers are also commonly added to encapsulate potential precipitants. Oxidant addition precipitates metal oxides for particle removal (converting soluble ferrous Fe ions to insoluble ferric Fe ions). 

Oxidant Removal The presence of oxidizers such as chlorine or ozone can degrade polyamide RO membranes, causing a drop in salt retention. Cellulosic membranes are less sensitive to attack. Addition of 1.5 to 6 mg sodium bisulfite/ppm chlorine or contacting with activated carbon will remove oxidizers. Vacuum degassing with a hydrophobic filter module is also used. 

Biocides Microorganisms can form biofilms on membrane surfaces, causing lower fluxes [Flemming in Reverse Osnwsis, Z. Amjad (ed.), Van Nostrand, New York, 1993, p. 163]. Cellulosic membranes... 

Table 20-24 compares properties of commonly used polyethersulfone (PES) or regenerated cellulose membranes. Membrane selection is based on experience with vendors, molecular weight rating for high... 

Renkin EM. (1954). Filtration, diffusion and molecular sieving through porous cellulose membranes. J Gen Physiol 38 225-238. 

C. A. Browne12 studied the cellulosio material obtained by fermentation of Louisiana sugar cane juice. His results substantiated those of A. J. Brown, and he further showed that since the nitrogen content of the membranes was only 0.2%, chitin could only be present with the cellulose membrane in traces, if at all. 

Probably the best optical sensors for pH are based on a pH indicator dye covalently immobilized on transparent cellulose membranes (Table 15). The pKa of the dye is 7.34 and colour changes from yellow to purple are observed upon deprotonation. The cellulose membrane exhibits still more than 50% of the initial colouration after two years of storage in distilled water at ambient light. 

Several functionalized membranes could be synthesized by conventional methods at room temperature. In contrast, microwave heating was employed for both the synthesis of the triazine membrane and the practical generation of an 8000-member library of triazines bound to an amino-functionalized cellulose membrane (Scheme 7.26). 

Scheme 7.26 Library generation on a cellulose membrane employing the SPOT technique.

A similar approach has been described by the same authors for the synthesis of related cyclic peptidomimetics [44]. A set often nucleophiles was employed for the substitution of the chlorine atom of the cyclic triazinyl-peptide bound to the cellulose membrane. By virtue of the aforementioned rate enhancement effects for nucleophilic substitution of the solid-supported monochlorotriazines, these reactions could be rapidly carried out by microwave heating. All products were obtained in high purity, enabling systematic modification of the molecular properties of the cyclic peptidomimetics. 

Scheme 7.27 Microwave-mediated synthesis and UV-induced cleavage of cyclic triazines on a cellulose membrane.

An 8000-member library of trisamino- and aminooxy-l,3,5-triazines has been prepared by use of highly effective, microwave-assisted nucleophilic substitution of polypropylene (PP) or cellulose membrane-bound monochlorotriazines. The key step relied on the microwave-promoted substitution of the chlorine atom in monochlorotriazines (Scheme 12.7) [35]. Whereas the conventional procedure required relatively harsh conditions such as 80 °C for 5 h or very long reaction times (4 days), all substitution reactions were found to proceed within 6 min, with both amines and solutions of cesium salts of phenols, and use of microwave irradiation in a domestic oven under atmospheric reaction conditions. The reactions were conducted by applying a SPOT-synthesis technique [36] on 18 x 26 cm cellulose membranes leading to a spatially addressed parallel assembly of the desired triazines after cleavage with TFA vapor. This concept was later also extended to other halogenated heterocycles, such as 2,4,6-trichloropyrimidine, 4,6-dichloro-5-nitropyrimidine, and 2,6,8-trichloro-7-methylpurine, and applied to the synthesis of macrocyclic peptidomimetics [37]. 

Scheme 12.7 High-speed nucleophilic substitution reactions on polypropylene or cellulose membranes.

Merrill, E. W., Salzman, E. W., Lipps, B. J., Jr., Gilliland, E. R., Austen, W. G., and Joison, J., Antithrombogenic cellulose membranes for blood dialysis. Transactions—American Society for Artificial Internal Organs 12, 139-150 (1966). 

Cellulosic hollow fibers, 16 18-20 Cellulosic materials, in ethanol fermentation, 10 535—536 Cellulosic membranes, in hemodialysis,... 

Modified carbon fibers, 13 383-385 Modified cellulosic membranes, in hemodialysis, 26 825, 826-828t Modified chemical vapor deposition (MCVD), in fiber optic fabrication, 11 136-137, 138, 139 Modified-Claus sulfur recovery process, 23 601, 602... 

Apart from not requiring filtering aids, such as a-cellulose, membrane filters are very simple to automate, since they can be immediately brought on-line after back-pulsing. Registers that are suitable for retrofitting have been developed by Permas-cand and Akzo Nobel and are employed by many other plants, such as those at Bayer Uerdingen. Their operation at these plants has been successful. 

This hydrogel coating may penetrate the larger pores of the cellulose membrane and can exclude protein from entering them (100% protein retention). So, the hydrogel coating reduces the irreversible fouling of the cellulosic surface. 

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