Integrin signaling

Giancotti, F. G., Integrin signaling specificity and control of cell survival and cell cycle progression, Curr. Opin. Cell. Biol., 9, 691-700, 1997. 

CD9 is a well-characterized hematopoietic tetraspan protein that has been shown to be present in CNS and PNS myelin, although it is present at higher levels in PNS myelin. In other cells, it is involved in integrin signaling and cell adhesion and motility. It is expressed at late stages of myelination and in the CNS is primarily found in paranodal junctions [34]. While compact CNS myelin is apparently normal in CD9-null animals, the paranodal loops are often disconnected from axonal membranes, and the transverse bands of the paranodal loops are lost. In the PNS, in addition to altered paranodes, hypermy-elination occurs. Thus, this tetraspan protein appears to act primarily at paranodes, where it is crucial for normal paranodal junctions. 

Fig. 17. A photoaffinity probe for integrin signaling and photoactivatable membrane probes...

PC3 Prostate Invasive (EMT) phenotype developed STAT/interferon, P13-kinase, AKT, and integrin signaling PI3-kinase inhibitors blocked invasive cell growth more effectively in 3-D (30)... 

Giancotti FG, Ruoslahti E (1999) Transduction - integrin signalling. Science 285 1028-1032... 

Giancotti FG (2000) Complexity and specificity of integrin signalling. Nat Cell Biol 2 E13-E14... 

The PINCH (Particnlarly Interesting New Cys/His rich protein) is a widely expressed adapter protein that contains five LIM domains that belong to gronp 3 of the LIM domain snbfamihes. PINCH is fonnd in focal adhesions, large ceUnlar complexes that link extracellnlar matrix to the actin cytoskeleton and has been implicated as a platform for mnltiple protein protein interactions that mediate integrin signaling within focal adhesions. ... 

Shattil, S.J., Kashiwagi, H., Pampori, M. (1998). Integrin signaling the platelet paradigm. Blood 91 2645-57. 

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