Sebaceous gland carcinoma

Layton, G. T., Devine, P. L., Warren, J. A., Birrell, G., Xing, P., Ward, B. G., and McKenzie, 1. F., (1990), Monoclonal antibodies reactive with the breast carcinoma-associated mucin core protein repeat sequence peptide also recognise the ovarian carcinoma-associated sebaceous gland antigen. Tumour Biol. 11, 274-286. 

Two-year studies were conducted by administering VCD in acetone by dermal application 5 days per week for over 100 weeks to groups of rats of each sex at 0, 15, or 30mg/animal and to groups of mice at 0, 2.5, 5, or lOmg/animal. Acanthosis and sebaceous gland hypertrophy of skin from the scapula were observed at increased incidences in both species. Squamous cell papillomas in male rats and squamous cell carcinomas in males and females were observed in exposed rats at an increased incidence. The combined incidence of basal cell adenomas or carcinomas was also increased in both sexes. Squamous cell carcinomas were found in the exposed mice. Follicular atrophy and tubular hyperplasia of the... 

Squamous-cell papillomas or carcinomas and sebaceous gland adenomas Squamous-cell papillomas and carcinomas Elepatocellular adenomas Alveolar/bronchiolar adenomas p < 0.05 Fisher s exact test p< 0.01 Fisher s exact test... 

Sebaceous gland adenomas and carcinomas or basal-cell tumours Follicular-cell adenomas and carcinomas Carcinomas... 

Male rats treated with isophorone in the NTP (1986) study also had preputial gland carcinomas, an extremely rare finding. Analogous tissues in humans are modified sebaceous glands in the prepuce (foreskin of the penis), but it is not known whether isophorone could cause tumors in these glands or other glandular tissues in humans. 

Figure 23-30 (AJ Recurrent sebaceous gland carcinoma of the right upper eyelid with ill-defined borders. (B) Postoperative right orbital exenteration and nasolacrimal duct resection of the patient in A. (Courtesy Dr. Nick Holdeman, University of Houston, College of Optometry.)...

Aside from whether they are directly active per se, or merely as precursors of active metabolic intermediates, carcinogenic polycyclic hydrocarbons can initiate carcinomas (e.g. epithelioma) at the point of application on the skin (the commonest mode of study), or can lead to distant tumours, as in bronchogenic cancer [23]. The mechanism probably includes solubilisation of the carcinogens (by proteins, nucleoproteins, fatty acid esters, etc. or even in aqueous solution [58]), so as to enable them to traverse the dermis (possibly via an external solvent) and thus react in the epidermis, which possesses a lipoid barrier. Alternatively, appendageal transport routes (hair follicles, sweat glands, sebaceous glands) may be used [59]. When carcinogens act at a distance, as with liver, breast, bladder and other internal cancers, an internal transport mechanism or medium is evidently needed. 

Skin and sweat glands Co-existent basal cell carcinomas and sebaceous gland hyperplasia occurred in a 55-year-old male renal transplant recipient who took ciclosporin for 9 years [12" ]. Both sebaceous gland hyperplasia and skin cancers are among the cutaneous neoplasms observed in ciclosporin-treated kidney transplant recipients, but co-existence has been seldom reported. 

Yayli S, Akyazi H, Bahadir S, Alpay K, Cobanoglu U. Coexistence of basal cell carcinomas and multiple sebaceous gland hyperplasias in a cyclosporine (ciclosporin)-treated renal transplant recipient. Am J Clin Dermatol 2010 11(1) 5 2. 

A number of recent reports have identified KS associated with epithelial surfaces. In adult tissues, keratinocytes, uterine endometrial cells, corneal endothelium, sebaceous gland, salivary gland, and sweat gland epithelia exhibit KS immunoreactivity [30-32]. Additionally KS is expressed by epithelial-derived carcinoma cells [33, 34]. Recently the endometrial protein MUCl was shown to bear KS chains [35]. This glycoprotein is a common component of the mucin layer associated with apical surfaces of secretory epithelia and could be responsible for the KS observed in many of these glandular surfaces. Another cell-surface molecule CD44 has been... 

Shinozaki A, Nagao T, Endo H, et al. Sebaceous epithelial-myoepithelial carcinoma of the salivary gland clinicopathologic and immunohistochemical analysis of 6 cases of a new histologic variant. Am J Surg Pathol. 2008 32(6) 913-923. 

The pathologic distinction between primary sebaceous carcinoma and metastatic renal cell carcinoma (RCC an important differential diagnostic alternative with a clear-cell appearance) is similar to that made earlier in reference to sweat gland carcinomas. Slow evolution of a solitary skin tumor favors a primary lesion. In addition, immunostaining for podoplanin is effective in this context that determinant is consistently present in sebaceous tumors, whereas it is absent in RCC. CD 10 is potentially seen in both lesional categories. TSS... 

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