Epithelial-myoepithelial carcinoma

The plasmacytoid variant may be mistaken for an extramedullary plasmacytoma. Clear cell myoepithelioma can be distinguished from an epithelial-myoepithelial carcinoma by the absence of ducts in myoepithelioma. Other clear cell tumors that might enter the differential... 

FIGURE 9.22 Epithelial-myoepithelial carcinoma demonstrating two cell populations and dense surrounding basement membrane. (H E, x200 original magnification.)... 

Epithelial-myoepithelial carcinoma is a biphasic tumor, composed of well-organized epithelial cells growing in ducts and tubules and surrounded by myoepithelial cells these are often encircled by dense hyalinized stroma. 

Donath K, Seifert G, Schmitz R. [Diagnosis and ultrastructure of the tubular carcinoma of salivary gland ducts. Epithelial-myoepithelial carcinoma of the intercalated ducts]. Yirch Arch A Pathol Pathologische Anat. 1972 356(1) 16-31. 

Seethala RR, Barnes EL, Hunt JL. Epithelial-myoepithelial carcinoma a review of the clinicopathologic spectrum and immu-nophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol. 2007 31(1) 44-57. 

Shinozaki A, Nagao T, Endo H, et al. Sebaceous epithelial-myoepithelial carcinoma of the salivary gland clinicopathologic and immunohistochemical analysis of 6 cases of a new histologic variant. Am J Surg Pathol. 2008 32(6) 913-923. 

Antic T, Venkataraman G, Oshima K. Oncocytic epithelial-myoepithelial carcinoma an evolving new variant with comparative immunohistochemistry. Pathology. 2008 40(4) 415-418. 

Kusafuka K, Takizawa Y, Ueno T, et al. Dedifferentiated epithelial-myoepithelial carcinoma of the parotid gland a rare case report of immunohistochemical analysis and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 106(1) 909-915. 

Eronseca I, Soares J. Proliferating cell nuclear antigen immunohistochemistry in epithelial-myoepithelial carcinoma of the salivary glands. Arch Pathol Lab Med. 1993 117(10) 993-995. 

Wang B, Brandwein M, Gordon R, et al. Primary salivary clear cell tumors—a diagnostic approach a clinicopathologic and immunohistochemical study of 20 patients with clear cell carcinoma, clear cell myoepithelial carcinoma, and epithelial-myoepithelial carcinoma [see comment]. Arch Pathol Lab Med. 2002 126(6) 676-685. 

Ro K, Srivastava A, Tischet AS. Bronchial epithelial-myoepithelial carcinoma. Arch Pathol Lab Med. 2004 128 92-94. 

Microscopically, PAs are composed of varying proportions of epithelial and myoepithelial cells and a stroma that ranges from myxoid to hyaline to chondromyxoid. Although the tumor is usually easily recognized when excised intact, it may be difficult to separate from other tumors, especially polymorphous low-grade adenocarcinomas and adenoid cystic carcinomas, on small biopsies. Features that may be helpful are shown in Table 9.12. 4,199-202... 

This tumor is similar to its counterpart in salivary glands in both morphology and immunophenotype and may arise in the cervix or vulvovaginal soft tissue. It is a dual-cell population tumor growing in cribriform, tubular, and/or solid patterns. The major cell type is a basaloid polygonal cell with modified myoepithelial features, and it is positive for p63 and smooth muscle actin. The minor cell type is an epithelial cell forming tiny ductules that may be inconspicuous. These cells express keratin and CD 117. Distinction from basaloid squamous carcinoma is based on the distinct morphology of adenoid cystic carcinoma because overlap exists in immunostains p63 is diffusely expressed in basaloid squamous carcinoma, as opposed to adenoid cystic carcinoma, in which p63 is confined to basaloid cells and not epithelium of the ductules CDl 17 can be expressed at low levels in basaloid squamous carcinoma. ... 

Nagle RB, Bocket W, Davis JR, et al. Gharacterization of breast carcinomas by two monoclonal antibodies distinguishing myoepithelial from luminal epithelial cells. J Histochem Cytochem. 1986 34 869-881. 

Detection of myoepithelial Squamous epithelium, cells in prostatic carcinoma basal epithelial cells, myoepithelial cells, mesothehal cells, cornea... 

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