Adenoma basal cell

Two-year studies were conducted by administering VCD in acetone by dermal application 5 days per week for over 100 weeks to groups of rats of each sex at 0, 15, or 30mg/animal and to groups of mice at 0, 2.5, 5, or lOmg/animal. Acanthosis and sebaceous gland hypertrophy of skin from the scapula were observed at increased incidences in both species. Squamous cell papillomas in male rats and squamous cell carcinomas in males and females were observed in exposed rats at an increased incidence. The combined incidence of basal cell adenomas or carcinomas was also increased in both sexes. Squamous cell carcinomas were found in the exposed mice. Follicular atrophy and tubular hyperplasia of the... 

Squamous-cell papillomas or carcinomas, basal-cell tumours, sebaceous adenomas, keratoacanthomas Squamous-cell papillomas or carcinomas Squamous-cell papillomas Adenocarcinomas Adenomatous polyps Adenomas... 

Sebaceous gland adenomas and carcinomas or basal-cell tumours Follicular-cell adenomas and carcinomas Carcinomas... 

Superscripts indicate the number and types of tumors a. subcutaneous fibroma b. skin, squamous cell carcinoma c. squamous cell carcinoma of uterus d. pulmonary adenoma e. papilloma of die skin f. basal cell carcinoma of the skin g. diyroid adenoma Only tumor types b, and f, were considered by die authors to be related to the HD exposure and only these types are counted in die... 

Pilar adenoma immunoprofile is similar to basal cell carcinoma (BCC) of skin epithelial membrane antigen (EMA), carcinoembryonic antigen, SI 00, CD15, and CA72.4 are negative. 

Salivary gland tumors (myoepithelial adenoma/ carcinoma, basal cell adenoma/carcinoma, pleomorphic adenoma)... 

Corticotropin secretion is unaff ed by GH-RIH in normal subjects (H3) both basally and in response to insulin hypoglycemia. However, Tyrrell et al. (Tl) have shown a significant faJl in elevated ACTH levels in Nelsons syndrome (4 patients) and in Cushing s disease (1 patient) in response to GH-RIH infusions. These results suggest that the mechanism determining release of ACTH by adenoma cells differ from that in normal pituitary cells. 

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