Cannabinoids CB1 receptor

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Cohen, C., Perrault, G., Griebel, G., Soubrie, P. Nicotine-associated cues maintain nicotine-seeking behavior in rats several weeks after nicotine withdrawal reversal by the cannabinoid (CB1) receptor antagonist, rimonabant (SR141716). Neuropsychopharmacology. 30 145, 2005. 

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See National Institute of Alcohol Abuse and Alcoholism, Protocol Number 04-AA-0072, Clinical Trial of the Cannabinoid CB1 Receptor Antagonist, SR141716(Rimonabant),to Reduce Voluntary Ethanol Drinking in Healthy, Non-Treatment Seeking Individuals Who Consume Between 20 and 40 Drinks Per Week http //clinicalstudies.info.nih.gov/deiail/A 2004-AA-0072.html... 

Colombo G et al The cannabinoid CB1 receptor antagonist, rimonabant, as a promising pharmacotherapy for alcohol dependence Preclinical evidence. Mol Neurobiol 2007 36 102. [PMID 17952655]... 

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Kahn L, Alonso G, Robbe D, Bockaert J, Manzoni OJ (2001) Group 2 metabotropic glutamate receptors induced long term depression in mouse striatal slices. Neurosci Lett 316(3) 178-82 Kamprath K, Marsicano G, Tang J, Monory K, Bisogno T, Di Marzo V, Lutz B, Wotjak CT (2006) Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes. J Neurosci... 

Mansbach RS, Rovetti CC, Winston EN, Lowe JA 3rd. Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats.Psychopharmacology (Berl). 1996 Apr 124(4) 315-22... 

Pertwee RG, Fernando SR (1996) Evidence for the presence of cannabinoid CB1 receptors in mouse urinary bladder. Br J Pharmacol 118(8) 2053—8 Pitler TA, Alger BE (1992) Postsynaptic spike firing reduces synaptic GABAa responses in hippocampal pyramidal cells. J Neurosci 12 4122-32 Porter AC, Sauer JM, Knierman MD, Becker GW, Bema MJ, Bao J, Nomikos GG, Carter P, Bymaster FP, Leese AB, Felder CC (2002) Characterization of a novel endocannabinoid, vi-rodhamine, with antagonist activity at the CB1 receptor. J Pharmacol Exp Ther 301(3) 1020-4 Rancillac A, Barbara JG (2005) Frequency-dependent recruitment of inhibition mediated by stellate cells in the rat cerebellar cortex. J Neurosci Res 80(3) 414-23... 

Tsou K, Brown S, Sanudo-Pena MC, Mackie K, Walker JM (1997) Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neurosci 83(2) 393 411 Van Beugen BJ, Nagaraja RY, Hansel C (2006) Climbing fiber-evoked endocannabinoid signaling heterosynaptically suppresses presynaptic cerebellar long-term potentiation. J Neurosci 26(32) 8289-94... 

Wolf MC, Leander JD (2003) SR141716A, a cannabinoid CB1 receptor antagonist, improves memory in a delayed radial maze task. Eur J Pharmacol 477(3) 213-17... 

Yoshida T, Hashimoto K, Zimmer A, Maejima T, Araishi K, Kano M (2002) The cannabinoid CB1 receptor mediates retrograde signals for depolarization-induced suppression of inhibition in cerebellar Purkinje cells. J Neurosci 22(5) 1690-7... 

Urigiien, L., Perez-Rial, S., Ledent, C., Palomo, T., and Manzanares, J. (2004). Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors. Neuropharmacology 46, 966-973. Vandrey, R. G., Budney, A. J., Moore, B. A., and Hughes, J. R. (2005). A cross-study comparison of cannabis and tobacco withdrawal. Am.J. Addict. 14, 54-63. 

Tsou, K., Mackie, K., Sanudo-Pena, M. C., and Walker, J. M. (1999). Cannabinoid CB1 receptors are localized primarily on cholecystokinin-containing gabaergic interneurons in the rat hippocampal formation. Neuroscience 93, 969-975. 

Morales M, Wang SD, Diaz-Ruiz O, Jho DH. Cannabinoid CB1 receptor and serotonin 3 receptor subunit A (5-HT3A) are co-expressed in GABA neurons in the rat telencephalon. J Comp Neurol 2004 468(2) 205-216. 

Eggan SM, Lewis DA. 2007. Immunocytochemical distribution of the cannabinoid CB1 receptor in the primate neocortex A regional and laminar analysis. Cereb Cortex 17 175-191. 

Tsou K, Brown S, Sanudo-Pena MC, Mackie K, Walker JM. 1998. Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience 83 393-411. 

Zavitsanou K, Garrick T, Huang XF. 2004a. Selective antagonist [3H]SR141716A binding to cannabinoid CB1 receptors is increased in the anterior cingulate cortex in... 

Cannabis is known to stimulate appetite, and promote food intake ( the munchies ). The identification of cannabinoid (CB1) receptors in the brain allowed the development of selective antagonist compounds such as Ri-monabant, which was found to suppresses food intake in laboratory animals (Colombo et al. 1998). Clinical trials have shown it to be significantly more effective than placebo in assisting overweight patients lose weight (see Chapter 8). 

Figure 20.1 Noladin ether (2), a cannabinoid CB1 receptor agonist, and its monophosphate prodrug (1) [22, 23],...

Cannabinoid CB1 receptor Topas Ligand-based evolutionary algorithm [108]... 

Glass, M, A. van Delicti, C. Blakemore, A.J. Hannan, and R.L.M. Faull (2004). Delayed onset of Huntington s disease in mice in an enriched environment correlates with delayed loss of Cannabinoid CB1 receptors. 

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