GABAergic interneurons

The cerebellar nuclei express mainly the NRl, NR2A and NR2D subunit genes (Watanabe et al., 1994). The NR3A gene is expressed at low levels in the adult cerebellum (cell types unknown) by RT-PCR, the NR3-L splice version predominates (Sun et al., 1998). 

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Gupta, A, Wang, Y and Markram, H (2000) Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex. Science 287 213-218. 

Katona I, Sperlagh B, Magloczky Z, Santha E, Kofalvi A, Czirjak S, Mackie K,Vizi ES, Freund TF. GABAergic interneurons are the targets of cannabinoid actions in the human hippocampus. Neuroscience 2000 100 797-804. 

Spinal disinhibition allows more nociceptive signal input. Following peripheral nerve injury there is a reduction in the GABAergic component of postsynaptic inhibitory currents caused by a degeneration of GABAergic interneurons [24] (Fig. 57-6). This loss of inhibition (disinhibition) results in an overall increase in the excitability of dorsal horn neurons. The degeneration of inhibitory interneurons is due to an excitotoxic effect of primary afferent ectopic activity on dorsal horn neurons [26]. 

Furlan, F., Taccola, G., Grandolfo, M., Guasti, L., Arcangeli, A., Nistri, A. and Ballerini, L. (2007) ERG conductance expression modulates the excitability of ventral horn GABAergic interneurons that control rhythmic oscillations in the developing mouse spinal cord. Journal of Neuroscience, 27, 919-928. 

The neuroanatomical data collected so far indicate that the CRH system is clearly in the position to modulate serotoninergic neurotransmission at the level of the raphe nuclei, not only directly but also indirectly via effects targeted to GABAergic interneurones. More detailed studies, however, will be needed... 

To achieve a strict time control of principal cells, GABAergic interneurons display several remarkable features. (1) Their action potential is traditionally faster than that of pyramidal cells and the kinetics of synaptic events that excite inhibitory cells are faster than those that excite pyramidal cells (Martina et al. 1998 Geiger et al. 1997). (2) The GABAergic interneurons are morphologically highly diverse, which reflects their multiple functions in neuronal networks... 

Woo TU, Whitehead RE, Melchitzky DS, Jewis DA (1998) A subclass of prefrontal GABA axon terminals are selectively altered in schizophrenia. Proc Natl Acad Sci U S A 95 5341-5346 Zhang Y, Perez Velazquez JL, Tian GE, Wu CP, Skinner FK, Caslen PL, Zhang L (1998) Slow oscillations (< 1 Hz) mediated by GABAergic interneuronal networks in rat hippocampus. J Neurosci 18 9256-9268... 

Glutamatergic pyramidal cells migrate in a radial fashion from the dorsal PVE, and are lineally distinct from GABAergic interneurons, which are tangentially... 

Benes, F.M. and Berretta, S. (2001) GABAergic interneurons implications for understanding schizophrenia and bipolar disorder. Neuropsychopharmacology 25 1—27. 

Dayer AG, Cleaver KM, Abouantoun T, Cameron HA (2005) GABAergic interneurons in the adult neocortex and striatum are generated from different precursors. J Cell Biol 168 415-427... 

Tsou, K., Mackie, K., Sanudo-Pena, M. C., and Walker, J. M. (1999). Cannabinoid CB1 receptors are localized primarily on cholecystokinin-containing gabaergic interneurons in the rat hippocampal formation. Neuroscience 93, 969-975. 

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