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Excitatory synaptic transmission

Calton JL, Wilson WA, Moore SD Reduction ofvoltage-dependent currents by ethanol contributes to inhibition of NMDA receptor-mediated excitatory synaptic transmission. Brain Res 816 142—148, 1999... [Pg.42]

Brown, DA, Gahwiler, BH, Marsh, SJ and Selyanko, A A (1986) Mechanisms of muscarinic excitatory synaptic transmission in ganglia and brain. Trends Pharmacol. Sci. 17 Suppl, 66-71. [Pg.135]

AMPA and kainate receptors are both blocked by quinoxalinediones but have different desensitization pharmacologies. AMPAreceptors are widespread throughout the CNS they serve as receptors for fast excitatory synaptic transmission mediated by glutamate. AMPA receptor subunits are GluRl-GluR4, kainate receptor... [Pg.273]

Tyrosine phosphorylation plays an important role in synaptic transmission and plasticity. Evidence for this role is that modulators of PTKs and PTPs have been shown to be intimately involved in these synaptic functions. Among the various modulators of PTKs, neuro-trophins have been extensively studied in this regard and will be our focus in the following discussion (for details of growth factors, see Ch. 27). BDNF and NT-3 have been shown to potentiate both the spontaneous miniature synaptic response and evoked synaptic transmission in Xenopus nerve-muscle cocultures. Neurotrophins have also been reported to augment excitatory synaptic transmission in central synapses. These effects of neurotrophins in the neuromuscular and central synapses are dependent on tyrosine kinase activities since they are inhibited by a tyrosine kinase inhibitor, K-252a. Many effects of neurotrophins on synaptic functions have been attributed to the enhancement of neurotransmitter release BDNF-induced increase in neurotransmitter release is a result of induced elevation in presynaptic cytosolic calcium. Accordingly, a presynaptic calcium-depen-dent phenomenon - paired pulse facilitation - is impaired in mice deficient in BDNF. [Pg.430]

Ali, D. W. and Salter, M. W. NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity. Curr. Opin. Neurobiol. 11 336-342, 2001. [Pg.433]

Clark, G. D., Happel, L. T., Zorumski, C. F. and Bazan, N. G. Enhancement of hippocampal excitatory synaptic transmission by platelet-activating factor Neuron 9 1211-1216, 1992. [Pg.589]

Disrupting the delicate balance of inhibitory and excitatory synaptic transmission can trigger the disordered, synchronous firing of neurons that underlies a seizure 630... [Pg.629]

Kainate receptors mediate a depression of evoked excitatory synaptic transmission in areas CA1 (40,88-90) and CA3 (35,37,91,92) of the hippocampus. There is strong evidence that in area CA1 the locus of this effect is presynaptic. Thus, activation of kainate receptors depresses release of L-glutamate from synaptosomes (88) and depresses both NMDA and AMPA receptor-mediated components of the evoked EPSC in parallel (88,90). Furthermore, the effects of kainate receptor activation on excitatory synaptic transmission in CA1 are associated with changes in presynaptic Ca2+ (89), an increase in paired-pulse facilitation (35,88,89), and a reduction in quantal content, as assessed using 1/CV2, but no change in mEPSC amplitude (90). [Pg.34]

Clarke, V. R. J. and Collingridge, G. L. (2002) Characterisation of the effects of ATPA, a GLUk5 receptor selective agonist, on excitatory synaptic transmission in area CA1 of rat hippocampal slices. Neuropharmacology 42, 889-902. [Pg.43]

Frerking, M., Schmitz, D., Zhou, Q., Johansen, J., and Nicoll, R. A. (2001) Kainate receptors depress excitatory synaptic transmission at CA3-CA1 synapses in the hippocampus via a direct presynaptic action. J. Neurosci. 21, 2958-2966. [Pg.45]

Contractor, A., Swanson, G. T., Sailer, A., O Gorman, S., and Heinemann, S. F. (2000) Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus. J. Neurosci. 20, 8269-8278. [Pg.46]

Rodriguez-Moreno, A., Sistiaga, A., Lerma, J., and Sanchez-Prieto, J. (1998) Switch from facilitation to inhibition of excitatory synaptic transmission by group I mGluR desensitization. Neuron 21,1477-1486. [Pg.80]

McGehee DS, Heath MJ, Gelber S, Devay P, Role LW. (1995). Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science. 269(5231) 1692-96. [Pg.457]

Vidal C, Changeux JP. (1993). Nicotinic and muscarinic modulations of excitatory synaptic transmission in the rat prefrontal cortex in vitro. Neuroscience. 56(1) 23-32. [Pg.466]

Excitatory synaptic transmission in the central nervous system is largely glu-tamatergic. There is ample evidence for inhibition of excitatory transmission... [Pg.156]

CS278 Whalley, B. J., J. D. Wilkinson, E. M. Williamson, and A. Constant . A novel component of cannabis extract potentiates excitatory synaptic transmission in rat olfactory cortex in vitro. Neurosci Lett 2004 365(1) 58-63. [Pg.106]

Zhou YD, Turner TJ, Dunlap K (2003) Enhanced G protein-dependent modulation of excitatory synaptic transmission in the cerebellum of the Ca2+ channel-mutant mouse, tottering. J Physiol 547 497—507. [Pg.252]

Jensen, T.P., Filoteo, A., Knopfel, T., Empson, R.M., 2007, Pre-synaptic plasma membrane Ca2+ ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3. J Physiol (Lond) 15,... [Pg.380]

Wang XQ, Deriy LV, Foss S, Huang P, Lamb FS, Kaetzel MA, Bindokas V, Marks JD, Nelson DJ (2006) CLC-3 channels modulate excitatory synaptic transmission in hippocampal neurons. Neuron 52 321-333. [Pg.106]

Pfrieger FW, Gottmann K, Lux HD (1994) Kinetics of GABAB receptor-mediated inhibition of calcium currents and excitatory synaptic transmission in hippocampal neurons in vitro. Neuron 12 97-107... [Pg.255]

Cheng LL, Wang SJ, Gean PW (1998) Serotonin depresses excitatory synaptic transmission and depolarization-evoked Ca2+ influx in rat basolateral amygdala via 5-HT]A receptors. Eur J Neurosci 10 2163-72... [Pg.327]

Nicola SM, Kombian SB, Malenka RC (1996) Psychostimulants depress excitatory synaptic transmission in the nucleus accumbens via presynaptic Dj-like dopamine receptors. J Neurosci 16 1591-604... [Pg.333]

Koizumi S, Fujishita K, Tsuda M et al (2003) Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures. Proc Natl Acad Sci USA 100 11023-8 Kubista H, Boehm S (2006) Molecular mechanisms underlying the modulation of exocytotic noradrenaline release via presynaptic receptors. Pharmacol Ther 112 213 42 Kukulski F, Sevigny J, Komoszynski M (2004) Comparative hydrolysis of extracellular adenine nucleotides and adenosine in synaptic membranes from porcine brain cortex, hippocampus, cerebellum and medulla oblongata. Brain Res 1030 49-56 Kurokawa M, Koga K, Kase H et al (1996) Adenosine A2a receptor-mediated modulation of striatal acetylcholine release in vivo. J Neurochem 66 1882-8 Kurz K, von Ktigelgen I, Starke K (1993) Prejunctional modulation of noradrenaline release in mouse and rat vas deferens contribution of PI- and P2-purinoceptors. Br J Pharmacol 110 1465-72... [Pg.367]

See other pages where Excitatory synaptic transmission is mentioned: [Pg.73]    [Pg.214]    [Pg.148]    [Pg.808]    [Pg.43]    [Pg.251]    [Pg.272]    [Pg.285]    [Pg.461]    [Pg.465]    [Pg.188]    [Pg.135]    [Pg.6]    [Pg.16]    [Pg.23]    [Pg.30]    [Pg.44]    [Pg.252]    [Pg.506]    [Pg.348]    [Pg.213]    [Pg.249]    [Pg.331]   
See also in sourсe #XX -- [ Pg.4 ]



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