Retrograde signaling

Ohno-Shosaku T, Maejima T, Kano M. Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals. Neuron 2001 29 729-738. [Pg.133]

Wilson RI, Nicoll RA. Endogenous cannabinoids mediate retrograde signaling at hippocampal synapses. Nature 2001 410 588-592. [Pg.135]

Endocannabinoids serve as retrograde messengers. They are released by postsynaptic neurons and act on presynaptic CB1 receptors on neighboring nerve terminals. Retrograde signaling by endocannabinoids is essential for many forms of synaptic plasticity that are initiated by postsynaptic depolarization and increased postsynaptic intracellular Ca2+> but expressed as a presynaptic decrease in the probability of transmitter release. Examples include some forms of long-term depression (LTD see Ch. 53) at GABA... [Pg.920]

Alger BE, Pitler TA (1995) Retrograde signaling at GABAA-receptor synapses in the mammalian CNS. Trends Neurosci 18 333-340... [Pg.240]

Long-term depression (LTD) is the loss of synaptic strength after passage of an impulse. There is evidence that during brain activity, including that in the hippocampus, both LTP and LTD are essential.10351036 LTD may depend upon cyclic ADP-ribose (p. 564).1037 LTD, like LTP, may also spread via retrograde signaling.1038... [Pg.1804]

Alger, B.E., Retrograde signaling in the regulation of synaptic transmission focus on endocannabinoids. Prog. Neurobiol., 68, 247-286, 2002. [Pg.661]

Harkany T, Holmgren C, Hartig W, Qureshi T, Chaudhry FA, Storm-Mathisen J, Dobszay MB, Berghuis P, Schulte G, Sousa KM, Fremeau RT, Jr., Edwards RH, Mackie K, Ernfors P, Zilberter Y (2004) Endocannabinoid-Independent Retrograde Signaling at Inhibitory Synapses in Layer 2/3 of Neocortex Involvement of Vesicular Glutamate Transporter 3. J Neurosci 24 4978 1988. [Pg.101]

Ohno-Shosaku T, MaejimaT, Kano M (2001) Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals. Neuron 29 729-38 Ohno-Shosaku T, Shosaku J, Tsubokawa H, Kano M (2002) Cooperative endocannabinoid production by neuronal depolarization and group I metabotropic glutamate receptor activation. Eur J Neurosci 15 953-61... [Pg.474]

Trettel J, Levine ES (2003) Endocannabinoids mediate rapid retrograde signaling at intemeuron-pyramidal neuron synapses of the neocortex. J Neurophysiol 89 2334-8 Trettel J, Fortin DA, Levine ES (2004) Endocannabinoid signalling selectively targets perisomatic inhibitory inputs to pyramidal neurones in juvenile mouse neocortex. J Physiol 556(Pt 1) 95-107... [Pg.476]

Yanovsky Y, Mades S, Misgeld U (2003) Retrograde signaling changes the venue of postsynaptic inhibition in rat substantia nigra. Neurosci 122 317-238... [Pg.478]

Yoshida T, Hashimoto K, Zimmer A, Maejima T, Araishi K, Kano M (2002) The cannabinoid CB1 receptor mediates retrograde signals for depolarization-induced suppression of inhibition in cerebellar Purkinje cells. J Neurosci 22(5) 1690-7... [Pg.478]

Role of the Canonical NO/cGMP/cGK Pathway in Retrograde Signalling... [Pg.542]

Kano, M., Ohno-Shosaku, T., and Maejima, T. (2002). Retrograde signaling at central synapses via endogenous cannabinoids. Mol. Psychiatry 7, 234-235. [Pg.349]

Retrograde Signaling that Regulates Synaptic Development and Function at the Drosophila Neuromuscular Junction... [Pg.456]

Maejima T, Hashimoto K, Yoshida T, Aiba A, Kano M. 2001. Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors. Neuron... [Pg.484]

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