Cancer therapy, using

Several kinds of cancer therapy use radiation to destroy malignant cells. Boron neutron capture therapy is unusual in that boron-10, the isotope injected, is not radioactive. However, when boron-10 is bombarded with neutrons, it gives off highly destructive a particles. In boron neutron capture therapy, the boron-10 is incorporated into a compound that is preferentially absorbed by tumors. The patient is then exposed to brief periods of neutron bombardment. As soon as the bombardment ceases, the boron-10 stops generating a particles. 

Almost all elements found in nature can now be made radioactive. Radioactive potassium and phosphorus are used as tracers to measure how effectively plants take up fertilizer from soil. Radioactive iodine is applied in nuclear medicine to diagnose and treat thyroid problems. Radiation treatment for cancer therapy uses radioactive cobalt, which is made by irradiating ordinary cobalt with neutrons. 

An interesting proposal for cancer therapy using Fe has been made by Mills et al. (81). They have claimed that delivery of Fe-bleomycin to tumor cells followed by photoactivation with 14.4-eV resonant Moss-bauer y rays can produce tumor regression at doses as low as 10" Gy. DNA damage appears to be caused by emission of Auger electrons, which leads to a cluster of positively charged ions and a molecular explosion. It remains to be seen whether this technique is useful only... 

Dass CR, Choong PF (2006) Selective gene delivery for cancer therapy using cationic liposomes in vivo proof of applicability. J Control Release 113 155-163... 

Nuclear Waste Disposal Cancer Therapy Using Radiation Nuclear Medicine Making Isotopes for Medical Applications... 

Hanash, S.M., Madoz-Gurpide, J., and Misek, D.E., 2002, Identification of novel targets for cancer therapy using expression proteomics. Leukemia 16 478-485. 

Shuhendler AJ, Chung R, Manias J, Connor A, Rauth AM, Wu XY. A novel doxombidn-mitomycin C co-encapsulated nanoparticle formulation exhibits anti-cancer synergy in multidrug resistant human breast cancer cells. Breast Cancer Res Treatment, submitted in 2008. Dass CR, Choong PFM. Selective gene delivery for cancer therapy using cationic liposomes In vivo proof of applicability. J Control Release 2006 113 155-163. 

For a general review on cancer therapies using natural products, see J. Mann, Nature Reviews Cancer 2002, 2, 143. 

Kim, J.Y., et al. Single-Cell-Level Cancer Therapy Using a Hollow Optical Fiber-Based Microplasma. Small 6(14), 1474—1478 (2010)... 

Near Infrared-IYiggered Synergetic Cancer Therapy Using Multifunctional Nanotheranostics... 

Many cancer therapies use non-S-phase-specific cytotoxic agents and the question arises whether a cell-cycle inhibitor like rhMIP-la/BB-10010 can protect normal cell from these agents. This question has been addressed using the clinically relevant non-S-phase-specific cytotoxic drug cyclophosphamide in murine chemotherapy models, which are typically less myeloablative than those described above (38). In these studies BB-10010 was administered continuously by osmotic minipump during days 0-7 at 40 pg... 

Scheinberg DA, Villa CH, Escorcia FE, McDevitt MR (2010) Conscripts of the infinite armada systematic cancer therapy using nanomaterials. Nat Rev Clin Oncol 7 266-276... 

Huber PE, lenne W, Raster R et al (2001) A new noninva-sive approach in breast cancer therapy using magnetic resonance imaging-guided focused ultrasound surgery. Cancer Res 61 8441-8447... 

Weider, M.E., Hone, D.C., Cook, M.J., Handsley, M.M., Gavrilovic J. and Russel, D.A. (2006) Intracellular photodynamic therapy with photosensitizer-nanoparticle conjugates cancer therapy using a trojan horse . Photochemical and Photobidogical Sciences, 5, 727-34. 

New Cancer Therapy Using FL as a In Vivo TNF-o Gene Transfer Vector... 

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