M-phase specific

Arion, D., Meijer, L., Brizuela, L., and Beach, D. (1988). cdc2 is a component of the M phase specific histone HI kinase evidence for identity withMPF. Cell 55 371-378. Balakier, H and Czolowska, R. (1977). Cytoplasmic control of nuclear maturation of mouse oocytes. Exp. Cell Res. 110 466-469. 

Gerhart, J., Wu, M., and Kirschner, M. (1984). Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs. J. Cell Biol. 98 1247-1255. 

The G]/S cyclins include the D and E type cyclins the M phase specific cyclins include the B type cyclins. Cyclins of type A are active in S, G2 and M phases. 

Examples of proteins that are specifically phosphorylated during the cell cycle are the lamins. Hyperphosphorylation of the lamins leads to disintegration of the nuclear lamina. Myosin in actin-myosin filaments is also specifically phosphorylated during mitosis. Other M-phase-specific phosphorylations occur at transcription factor TFIIIB, leading to inhibition of transcription by RNA polymerase III. Phosphorylation of TAP proteins (see 1.4.2.3) is also involved in general inhibition of banscription. 

Peter M, Nakagawa J, Doree M, Labbe JC, Nigg EA. In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase. Cell 1990 61 591-602. 

The M-phase-specific cyclins include the B type cyclins. 

S-phase-specific drugs like adriamycin or M-phase-specific drugs like vincristine. If these possible hazards can be ruled out, a drug like PEG-l-ASP may represent a significant step ahead toward better tolerance of the enzyme. 

Antineoplastic plant alkaloid cell cycle (M phase)-specific agent inhibits mitotic spindle formation. Tox peripheral neuropathy. Vinblastine, a congener, causes myelosuppression. 

Bleomycin G2/M-phase-specific Bithiazole rings intercalate into DNA strand. Drug oxidizes Fe " ", yielding free radicals which damage DNA. ... 

Vincristine M-phase-specific Binds tubulin, depolymerizes microtubules. Decreased drug uptake and retention, multi-drug resistance... 

Meijer L, Arion D, Golsteyn R, Pines J, Biizuela L, Hunt T, Beach D. 1989a. Cyclin is a component of the sea urchin egg M-phase specific histone HI kinase. EMBO J 8(8) 2275-2282. 

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