Cancer single nucleotide polymorphisms

Clifford, R., et al., "Expression-Based Genetic/Physical Maps of Single Nucleotide Polymorphisms Identified by the Cancer Genome Anatomy Project," Genome Res., 10, 1259-1265 (2000). 

Wang, W.W., et al., "A Single Nucleotide Polymorphism in the 5 Untranslatcd Region of RAD51 and Risk of Cancer Among BRCA1 /2 Mutation Carriers," Cancer Epid. Biomarkers Prev., 10, 955-960 (2001). 

Mizuarai, S., Aozasa, N., and Kotani, H. (2004) Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2. Int. J. Cancer 109, 238-246. 

Moiisaki, K., Robey, R. W., Ozvegy-Laczka, C., et al. (2005) Single nucleotide polymorphisms modify the transporter activity of ABCG2. Cancer Chemother. Pharmacol. 56, 161-172. 

Due to their functional involvement in specific molecular pathways, miRNAs have become interesting targets for therapeutic intervention. Examples of disease-related mechanisms affected by miRNAs include single-nucleotide polymorphisms (SNPs) in 3 UTR sequences (23, 24) or in miRNA genes (25, 26) that may affect normal protein expression and has been identified in association with heart failure (27) and cancer (25, 28). Chromosomal deletions and epigenetic changes involving miRNA also cause abnormal protein expression that is associated with malfunctions... 

Primdahl H, Wikman FP, von der Maase H et al. Allelic imbalances in human bladder cancer genome-wide detection with high-density single-nucleotide polymorphism arrays. J Natl Cancer Inst 2002 94 216-223. 

Nannya Y, Sanada M, Nakazaki K et al. A robust algorithm for copy number detection using high-density oligonucleotide single-nucleotide polymorphism genotyping arrays. Cancer Res 2005 65 6071-6079. 

Janne PA, Li C, Zhao X et al. High-resolution single-nucleotide polymorphism array and clustering analysis of loss of heterozygosity in human lung cancer cell lines. Oncogene 2004 23 2716-2726. 

Hoque MO, Lee J, Begum S et al. High-throughput molecular analysis of urine sediment for the detection of bladder eaneer by high-density single-nucleotide polymorphism array. Cancer Res 2003 63 5723-5726. 

Lieberfarb ME, Lin M, Lechpammer M et al. Genome-wide loss of heterozygosity analysis from laser capture microdissected prostate eaneer using single nucleotide polymorphic allele (SNP) arrays and a novel bioinformaties platform dChipSNP. Cancer Res 2003 63 4781 785. 

Zhao X, Li C, Paez JG et al. An integrated view of eopy number and allelic alterations in the eaneer genome using single nucleotide polymorphism arrays. Cancer Res 2004 64 3060-3071. 

Wong KK, Tsang YT, Chang YM et al. Genome-wide allelie imbalanee analysis of pediatric gliomas by single nucleotide polymorphic allele array. Cancer Res 2006 66 11172-11178. 

Lips EH, Dierssen JW, van Eijk R et al. Reliable high-throughput genotyping and loss-of-heterozygosity detection in formalin-fixed, paraffin-embedded tumors using single-nucleotide polymorphism arrays. Cancer 2005 65 10188-10191. 

Fig. 2. Regulation of thymidylate synthase (TS) gene expression. Abbreviations.- TS (thymidylate synthase) USF-1 (upstream stimulating factor 1) USF-2 (upstream stimulating factor 2) SNP (single nucleotide polymorphism). (Reprinted with permission of El-Khoueiry et al. Pharmacogenomics and molecular biology of gastrointestinal cancers, Atlas of Gastrointestinal Cancers, Current Medicine Group, LLC, Philadelphia, 2007).

Kawakami K, Watanabe G. Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene. Cancer Res 2003 63 6004-6007. 

Mareuello E, Altes A, del Rio E et al. Single nucleotide polymorphism in the 5 tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients. Int J Cancer 2004 112 733-737. 

Masi, T. et al. 2005. Nitrosamine 4-(methylnitrosamino) -1 - (3-pyridyl) -1-butanone-induced pulmonary adenocarcinomas in Syrian golden hamsters contain beta-2-adrenergic receptor single-nucleotide polymorphisms. Genes Chromosomes Cancer, 44 (2), 212-217. 

Bharaj BB, Luo LY, Jung K, Stephan C, Diamandis EP. Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK 10) gene and their association with prostate, breast, testicular, and ovarian cancers. Prostate 2002 51 35 11. 

Bharaj B, Scorilas A, Diamandis EP, et al. Breast cancer prognostic significance of a single nucleotide polymorphism in the proximal androgen response element of the prostate specific antigen gene promoter. Breast Cancer Res Treat 2000 61 111-119. 

Honjo Y, Morisaki K, Huff LM, Robey RW, Hung J, Dean M, Bates SE. Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1). Cancer Biol Ther 2002 1 696-702. 

Zhu Y, Spitz MR, Amos Cl, Lin J, Schabath MB, Wu X. An evolutionary perspective on single-nucleotide polymorphism screening in molecular cancer epidemiology. Cancer Res 2004 64 2251-2257. 

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