Androgen response elements

Bharaj B, Scorilas A, Diamandis EP, et al. Breast cancer prognostic significance of a single nucleotide polymorphism in the proximal androgen response element of the prostate specific antigen gene promoter. Breast Cancer Res Treat 2000 61 111-119. 

Murtha P, Tindall DJ, Young CY. Androgen induction of a human prostate-specific kallikrein, hKLK2 Characterization of an androgen response element in the 5 promoter region of the gene. Biochemistry 1993 32 6459-6464. 

Riegman PH, Vlietstra RJ, van der Korput JA, Brinkmann AO, Trapman J. The promoter of the prostate-specific antigen gene contains a functional androgen responsive element. Mol Endocrinol 1991 5 1921-1930. 

L15. Luke, M. C., and Coffey, D. S., Human androgen receptor binding to the androgen response element of prostate specific antigen. J. Androl. 15,41—51 (1994). 

Crossley M, Ludwig M, Stowell KM, et al. Recovery from hemophilia B Leyden an androgen-responsive element in the factor IX promoter. Science 1992 257 377-379. 

Shaffer PL, Jivan Arif, Dollins DE, et al. Structural basis of androgen receptor binding to selective androgen response elements. Proc Natl Acad Sci U S A 2004 101 4758-4763. 

Hsiao PW, Thin TH, Lin DL, et al. Differential regulation of testosterone vs. 5a-dihydrotestosterone by selective androgen response elements. Mol Cell Biochem 2000 206 169-175. 

Hgure 2 Conversion of testosterone (T) to dihydotestosterone (DHT) by 5a-reductase (5aR), interaction of DHT with the androgen receptor (AR), and binding of the DHT-AR complex to the androgen response elements (ARE) in the androgen signaling pathway. 

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