Thymidylate synthase gene

Thymidylate Synthase Gene Promoter Polymorphism and Response to 5-Flurouracil-Based Chemotherapy... 

Johnston PG, Lenz HJ, Leichman CG et al. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 1995 55 1407-1412. 

Ulrich CM, Bigler J, Velicer CM et al. Searching expressed sequence tag databases discovery and confirmation of a common polymorphism in the thymidylate synthase gene. Cancer Epidemiol Biomarkers Prev 2000 9 1381-1385. 

Kawakami K, Omura K, Kanehira E et al. Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers. Anticancer Res 1999 19 3249-3252. 

VlLLAFRANCA E, OKRUZHNOV Y, DOMIN-guez MA et al. Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer. J Clin Oncol 2001 19 1779-1786. 

In 1995, Horie et al. described a polymorphic tandem repeat found in the 5 -un-translated region of the thymidylate synthase gene [70]. Thymidylate synthase (TS TYMS) catalyzes the intracellular transfer of a methyl group to deoxyuridine-5-monophosphate (dUMP) to form deoxythymidine-5-monophosphate (dTMP), which is anabolized in cells to the triphosphate (dTTP). This pathway is the only de- novo source of thymidine, an essential precursor for DNA synthesis and repair. The methyl donor for this reaction is the folate cofactor 5,10-methylenetetrahydro-folate (CH2-THF) (Figure 24.4). 

Pullarkat, S. T., Stoehlmacher, J., Ghaderi, V., et al. (2001) Thymidylate synthase gene polymorphism determines response and toxicity of 5-EU chemotherapy. Pharmacogenomics Journal. 1, 65-70. 

Ulrich, C. M., Bigler, J., Velicer, C. M., Greene, E. A., and Earin, F. M., Potter, J. D. (2000) Searching expressed sequence tag databases discovery and confirmation of a common polymorphism in the thymidylate synthase gene. Cancer Epidemiology, Biomarkers and Prevention. 9, 1381-1385. 

Kawakami K. Thymidylate synthase gene in pharmacogenetics, current Pharmacogenomics 2004 2 137-147. 

Role of Thymidylate Synthase Gene Variations in Colorectal Cancer Patients... 

Ichikawa W, Uetake H, Shirota Y et al. Combination of dihydropyrimidine dehydrogenase and thymidylate synthase gene expressions in primary tumors as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer. Clin Cancer Res 2003 9 786-791. 

Mandola MV, Stoehlmacher J, Muller-Weeks S et al. A novel single nueleotide polymorphism within the 5 tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transeriptional aetivity. Cancer Res 2003 63 2898-2904. 

Gibson TB. Polymorphisms in the thymidylate synthase gene predict response to 5-fluorouracil therapy in colorectal cancer. Clin Colorectal Cancer 2006 5 321-323. 

Mandola MV, Stoehlmacher J, Zhang W et al. A 6bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels. Pharmacogenetics 2004 14 319-327. 

Kawakami K, Watanabe G. Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene. Cancer Res 2003 63 6004-6007. 

Morganti M, Ciantelli M, Giglioni B et al. Relationships between promoter polymorphisms in the thymidylate synthase gene and mRNA levels in eoloreetal cancers. iiMrJCawcer 2005 41 2176-2183. 

Hitre E, Budai B, Adleff V et al. Influenee of thymidylate synthase gene polymorphisms on the survival of eoloreetal eaneer patients reeeiving adjuvant 5-fluorouracil. Pharmacogenet Genomics... 

Mareuello E, Altes A, del Rio E et al. Single nucleotide polymorphism in the 5 tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients. Int J Cancer 2004 112 733-737. 

Role of the Folate-Pathway and the Thymidylate Synthase Genes in Pediatric Acute Lymphoblastic Leukemia Treatment Response... 

Thymidylate Synthase Gene Reduced Folate Carrier (RFC) Gene Discussion References... 

Kaneda S, Nalbantoglu J, Takeishi K et al. Struetural and funetional analysis of the human thymidylate synthase gene. J Biol Chem 1990 265 20277-20284. 

Krajinovie M, Costea I, Chiasson S. Polymorphism of the thymidylate synthase gene and outcome of acute lymphoblastic leukaemia. Lancet 2002 359 1033-1034. 

Krajinovie M, Costea I, Primeau M et al. Combining several polymorphisms of thymidylate synthase gene for pharmacogenetic analysis. Pharmacogenomics J 2005,5 314-39,0. 

Lauten M, Asgedom G, Welte K et al. Thymidylate synthase gene polymorphism and its association with relapse in childhood B-cell precursor acute lymphoblastic leukemia. Haematologica... 

Pullarkat ST, Stoehlmacher J, Ghaderi V et al Thymidylate synthase gene polymorphism determines response and toxieity of 5-FU chemotherapy. Pharmacogenomics J 2001 1 65-70. 

Steidler et al. [47] have already developed and validated in pigs a passive containment system for the L. lactis expressing human IL-10 by deleting the thymidylate synthase gene which is essential for their growth (the resulting strain being dependent on thymidine or thymine). 

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