Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Human kallikrein

Doering K, Meder G, Hinnenberger M, Woelcke J, Mayr LM, Hassiepen U (2009) A fluorescence lifetime-based assay for protease inhibitor profiling on human kallikrein 7. J Biomol Screen 14 1-9... [Pg.35]

Official and Other Gene and Protein Names for Members of the Human Kallikrein Gene Family ... [Pg.14]

Recent data from the Chimpanzee Genome Project have revealed that the chimpanzee KLK locus is strikingly similar to the human locus, spans about 350 kb of genomic sequence on chromosome 20, and contains orthologues to all human kallikrein genes, with an overall >99% sequence similarity at the DNA and amino acid levels (our unpublished data). [Pg.17]

The human kallikrein locus contains a unique minisatellite element that is restricted to chromosomal band 19ql3, and ten clusters of this minisatellite are distributed along the kallikrein locus. These clusters are mainly located... [Pg.19]

Coordinates of all Genes and Pseudogenes Contained within the Human Kallikrein Locus Numbers are given According to GenBank Contig NT 011109... [Pg.20]

The crystal structure has been revealed for some rodent kallikreins. The three-dimensional structure of a horse orthologue of the human hK3 has also been reported [28]. In contrast, hKl and hK6 are the only human kallikreins for which crystal structures have been determined [48-50]. Most of the discussion in this section is derived from comparative model building of the human kallikrein proteins. [Pg.23]

Kallikreins can be roughly divided into two categories, the classical kallikreins (hKl, hK2, and hK3) and the new kallikreins. The new kallikreins appear to be unique in their three-dimensional structure and share some features with trypsins and other features with the classical kallikreins. Comparative protein models show that the pattern of hydrophobic side-chain packing in the protein core is nearly identical in all human kallikreins, and the observed differences occur within the solvent-exposed loop segments. [Pg.23]

Promoter analysis and hormonal stimulation experiments allowed us to obtain insights into the mechanisms that regulate expression of the human kallikrein genes. In addition to KLK3 and KLK2, and more recently KLK10, no other kallikrein gene promoter has been functionally tested. [Pg.30]

Reported Splice Variants of the Human Kallikrein Genes... [Pg.42]

Fifth, certain kallikreins, such as human kallikrein 6, are highly expressed in the central nervous system. It has previously been shown that hK6, and possibly some other kallikreins, are implicated in inflammatory reactions within the central nervous system that lead to demyelination. The association of hK6 and some other kallikreins with AD and multiple sclerosis points to the possibility that some of these enzymes may play important roles within the central nervous system. In addition, many of these enzymes have been found in endocrine tissues such as the islets of Langerhans, thyroid, pituitary, and others, pointing to the possibility that they may participate in prohormone or hormone processing. [Pg.64]

Rittenhouse HG, Finlay JA, Mikolajczyk SD, Partin AW. Human Kallikrein 2 (hK2) and prostate-specific antigen (PSA) Two closely related, but distinct, kallikreins in the prostate. Crit Rev Clin Lab Sci 1998 35 275-368. [Pg.66]

Riegman PH, Vlietstra RJ, Suurmeijer L, Cleutjens CB, Trapman J. Characterization of the human kallikrein locus. Genomics 1992 14 6-11. [Pg.66]

Yousef GM, Chang A, Scorilas A, Diamandis EP. Genomic organization of the human kallikrein gene family on chromosome 19ql3.3-ql3.4. Biochem Biophys Res Commun... [Pg.66]

Clements J, Hooper J, Dong Y, Harvey T. The expanded human kallikrein (KLK) gene family Genomic organisation, tissue-specific expression and potential functions. Biol... [Pg.66]

Yousef GM, Bharaj BS, Yu H, Poulopoulos J, Diamandis EP. Sequence analysis of the human kallikrein gene locus identifies a unique polymorphic minisatellite element. Biochem Biophys Res Commun 2001 285 1321-1329. [Pg.66]

Yousef GM, Diamandis EP. Human kallikreins Common structural features, sequence analysis and evolution. Curr Genomic 2003 4 147-165. [Pg.67]

Bernett MJ, Blaber SI, Scarisbrick IA, Dhanarajan P, Thompson SM, Blaber M. Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsinlike kallikrein is expressed in the central nervous system. J Biol Chem 2002 277 24562-24570. [Pg.67]

Yousef GM, Scorilas A, Jung K, Ashworth LK, Diamandis EP. Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer. J Biol Chem 2001 276 53-61. [Pg.67]

Bharaj BB, Luo LY, Jung K, Stephan C, Diamandis EP. Identification of single nucleotide polymorphisms in the human kallikrein 10 (KLK 10) gene and their association with prostate, breast, testicular, and ovarian cancers. Prostate 2002 51 35 11. [Pg.67]

Diamandis EP, Yousef GM, Soosaipillai AR, et al. Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications. Clin Biochem 2000 33 369-375. [Pg.68]

Kishi T, Grass L, Soosaipillai A, Shimizu-Okabe C, Diamandis EP. Human kallikrein 8 Immunoassay development and identification in tissue extracts and biological fluids. Clin Chem 2003 49 87-96. [Pg.68]

Yousef, G. M., Polymeris, M. E., Grass, L., et al. Human kallikrein 5 A potential novel serum biomarker for breast and ovarian cancer. Cancer Res 2003 63 3958-3965. [Pg.68]

Petraki CD, Karavana VN, Luo L-Y, Diamandis EP. Human kallikrein 10 expression in normal tissues by immmunohistochemistry. J Histochem Cytochem 2002 50 1247-1261. [Pg.68]

Petraki CD, Karavana VN, Revelos KI, Luo LY, Diamandis EP. Immunohistochemical localization of human kallikreins 6 and 10 in pancreatic islets. Histochem J 2002 34 313-322. [Pg.69]

Petraki CD, Gregorakis AK, Vaslamatzis MM, Papanastassiou P, Yousef GM, Diamandis EP. The immunohistochemical expression of human kallikreins 5, 6, 10 and 11 in renal cell carcinoma. Correlation with several prognostic factors. Proc AACR 2003 44 1077, abstract 5412. [Pg.69]

McCormack RT, Rittenhouse HG, Finlay JA, et al. Molecular forms of prostate-specific antigen and the human kallikrein gene family A new era. Urology 1995 45 729-744. [Pg.69]

Chang A, Yousef GM, Scorilas A, et al. Human kallikrein gene 13 (KLK13) expression by quantitative RT-PCR An independent indicator of favourable prognosis in breast cancer. Br J Cancer 2002 86 1457-1464. [Pg.69]

Luo LY, Katsaros D, Scorilas A, et al. Prognostic value of human kallikrein 10 expression in epithelial ovarian carcinoma. Clin Cancer Res 2001 7 2372-2379. [Pg.69]

See other pages where Human kallikrein is mentioned: [Pg.295]    [Pg.12]    [Pg.12]    [Pg.12]    [Pg.13]    [Pg.15]    [Pg.15]    [Pg.17]    [Pg.18]    [Pg.18]    [Pg.19]    [Pg.19]    [Pg.23]    [Pg.23]    [Pg.37]    [Pg.40]    [Pg.58]    [Pg.63]   
See also in sourсe #XX -- [ Pg.7 ]



SEARCH



Kallikrein

Kallikreins

© 2024 chempedia.info